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카탈로그 번호 | 수량 |
---|---|
4404336 | 1 L |
4404338 | 50 mL |
4404337 | 250 mL |
4404335 | 5 L |
4404334 | 10 L |
A major improvement on traditional cation exchangers, POROS™ XS resin sets the standard for cation exchange chromatography.
Dynamic Binding Capacity
POROS™ XS resin has a high binding capacity of more than 100 mg/mL, at 5% breakthrough, over a broad range of process conditions. Figure 1 demonstrates unparalleled binding capacity across a broad range of pH and salt conditions. Higher dynamic binding capacity was achieved by optimizing the base bead pore structure and surface chemistry.
High Resolution
Using an optimized 50 μm particle size, POROS™ XS resin maintains the superior resolving capacity of POROS™ HS resin (Figure 2) while overcoming the challenging impurity levels associated with high titer processes. Resolution is consistent across a wide range of operating flow rates (Figure 3) and maintained independent of protein load (Figure 4).
Robust Salt Tolerance
POROS™ XS resin has high and consistent protein capacity across a broad range of salt concentrations (Figure 5) up to 150 mM NaCl (15 mS/cm conductivity). The ability to load columns under higher conductivity reduces or helps eliminate the dilution of column feed streams or the removal of unit operations, such as tangential flow filtration. The optimized surface ionic capacity of POROS™ XS resin minimizes competitive binding between the protein of interest and the counterion, resulting in superior salt tolerance.