POROS™ Oligo (dT)25 Affinity Resin
POROS™ Oligo (dT)25 Affinity Resin
Thermo Scientific™

POROS™ Oligo (dT)25 Affinity Resin

Thermo Scientific™ POROS™ Oligo (dT)25 Affinity Resin is designed for the purification and isolation of mRNA from in vitro transcription (IVT) manufacturing processes.
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카탈로그 번호수량
A4860625 mL
A4860510 mL
A4738250 mL
A47383250 mL
A473841 L
A473855 L
A4738610 L
카탈로그 번호 A48606
제품 가격(KRW)
-
수량:
25 mL
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POROS Oligo (dT)25 Affinity Resin is designed for the purification and isolation of mRNA from in vitro transcription (IVT) manufacturing processes. The resin effectively separates mRNA from components of the transcription reaction process, such as enzymes and plasmid DNA.

POROS Oligo (dT)25 Affinity Resin was developed to address the selectivity and capacity requirements for large-scale downstream purification of a range of mRNA constructs used in vaccine and gene therapy applications. Unlike alternate approaches, the resin selectively captures the mRNA via the polyadenylated (polyA) tail using simple salt and water purification steps.

Features of POROS Oligo (dT)25 Affinity Resin include:

  • Easy mRNA purification from crude transcription mix to effectively remove plasmid DNA and other IVT components
  • Simplified workflow helps to maximize efficiency, thereby reducing complexity of subsequent polish steps
  • Excellent scalability
  • Non-animal derived

POROS Oligo (dT)25 Affinity Resin allows for a robust platform and efficient purification process for a range of mRNA molecules and applications.

Pack sizes of 1 L and above come with a regulatory support package. Worldwide technical support is also available.

Main characteristics

  • Matrix: cross-linked poly(styrene-divinylbenzene) POROS beads
  • Average particle size: 50 μm
  • Ligand: poly(dT) 25mer with proprietary linker
  • Binding capacity: >2 mg mRNA per mL of resin
  • Binding conditions: 0.5–1 M salt, common buffers, neutral pH
  • Elution conditions: Low salt, common buffers, neutral pH
  • Mechanical resistance: 100 bar (1450 psi; 10 MPa)
  • Thermal stability: allows sample denaturing at 65°C if needed
  • Formulation buffer: 18% (v/v) ethanol

Oligo (dT) ligands are manufactured using a synthetic manufacturing process that are free of animal components.

For Research Use Only. Not for use in diagnostic procedures.
사양
결합 용량>2 mg mRNA per mL of resin
매트릭스Cross-linked poly(styrene-divinylbenzene) POROS beads
수량25 mL
배송 조건Wet Ice
정지상Poly(dT) 25mer with proprietary linker
타겟mRNA
형태Liquid Suspension
입자 크기50 μm
제품라인POROS™
유형Bulk Resin
Unit SizeEach
구성 및 보관
Store at 2°C to 8°C.
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문서 및 다운로드

Certificates | 증명서

Lot 번호Certificate TypeDateCatalog Number(s)
ODT25-020Certificate of Analysis2025년 6월 24일A47384
ODT25-019Certificate of Analysis2025년 6월 16일A47385
ODT25-018Certificate of Analysis2025년 6월 16일A47382
ODT25-019Certificate of Analysis2025년 6월 02일A47384
ODT25-018Certificate of Analysis2025년 5월 12일A48605
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Safety Data Sheets | 물질 안전 보건 자료

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