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Invitrogen
Tobemstomig Recombinant Human Monoclonal Antibody
Product Details
MA5-60158
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG1
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Conjugate
Unconjugated
Form
Lyophilized
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
AB_3683059
Product Specific Information
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
Target Information
Tobemstomig is a biosimilar that acts as a bispecific monoclonal antibody targeting the PD-1 (programmed cell death protein 1) and LAG-3 (lymphocyte-activation gene 3) checkpoints. Lymphocyte Activation Gene-3 (LAG3) is a type I transmembrane protein with structural similarities to CD4 and is encoded by the LAG3 gene located on chromosome 12p13. The protein is highly upregulated on exhausted T cells in the tumor microenvironment and functions as an immune checkpoint receptor. Upon binding to MHC class II molecules, LAG3 transmits inhibitory signals to T cells, leading to T cell dysfunction, making it a significant target for cancer immunotherapy. PDCD1, on the other hand, encodes the Programmed Cell Death Protein 1 (PD-1), which is found on chromosome 2q37.3. PD-1 is a receptor expressed on the surface of immune cells, particularly T cells, and interacts with its ligands PD-L1 and PD-L2 to suppress T cell inflammatory activity, thus preventing autoimmunity. Both LAG3 and PD-1 play crucial roles in modulating immune responses, particularly through their inhibitory actions in the tumor microenvironment. These genes are primarily targeted in combination cancer immunotherapies aimed at restoring the immune system's ability to eradicate cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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