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            • Primary Antibodies ›
            • SNRPN Antibodies

            Invitrogen

            SNRPN Polyclonal Antibody

            View all (13) SNRPN antibodies
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            Cite SNRPN Polyclonal Antibody

            Product Details

            PA5-80046

            Product Specifications

            Species Reactivity

            Human, Mouse, Rat

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN (31-48aa FKAFDKHMNLILCDCDEF).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Concentration

            500 µg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            PBS with 5mg BSA

            Contains

            0.05mg sodium azide, 0.05mg thimerosal

            Storage conditions

            -20°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2747161

            Product Specific Information

            Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

            Target Information

            The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

            ⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: DKFZp686C0927; DKFZp686M12165; DKFZp761I1912; DKFZp762N022; FE294 gene for snRNP-associated polypeptide N; FE294 psi pseudogene; FLJ33569; FLJ36996; FLJ39265; MGC29886; Sm protein D; SM protein N; Sm-D; Sm-N; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; Small nuclear ribonucleoprotein-associated protein N; smN; snRNP-N; tissue-specific splicing protein; Tissue-specific-splicing protein

            View more View less

            Gene Aliases: 2410045I01Rik; FE 294; FE 294 psi; FE294; FE294 psi; HCERN3; Peg4; PWCR; Pwcr1; RT-LI; SM-D; sm-N; SMN; SNRNP-N; SNRPN; SNURF-SNRPN

            View more View less

            UniProt ID: (Human) P63162, (Rat) P63164, (Mouse) P63163

            View more View less

            Entrez Gene ID: (Human) 6638, (Rat) 81781, (Mouse) 20646

            View more View less

            Function(s)

            RNA binding protein binding molecular_function poly(A) RNA binding RNA splicing factor

            Process(es)

            mRNA splicing, via spliceosome RNA splicing response to hormone
            It has to be done as per old AB suggested Products section.
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