This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
Ibuprofen is a nonsteroidal anti-inflammatory drug commonly used in its racemic form
(S)-(+)-Ibuprofen is the active enantiomer of this drug that confers anti-inflammatory activity
(S)-(+)-Ibuprofen inhibits prostaglandin synthesis and thus reduces inflammation and pain when ingested
Applications
As the active enantiomer of ibuprofen, (S)-(+)-Ibuprofen is used in laboratory research for pharmacokinetic studies
(S)-(+)-Ibuprofen may be used as an inhibitor of cycloogenase 1 and 2 and an agonist of PPARalpha and PPARgamma
(S)-(+)-Ibuprofen may be used as material to study development of drug delivery systems
References
Kato, M.; Nishida, S.; Kitasato, H.; Sakata, N.; Kawai, S. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 2001, 53(12), 1679-85.
Davies, N.M. Clinical pharmacokinetics of ibuprofen. The first 30 years. Clin Pharmacokinet. 1998, 34(2), 101-54.
Jaradat, M.S.; Wongsud, B.; Phornchirasilp, S.; Rangwala, S.M.; Shams, G.; Sutton, M.; Romstedt, K.J.; Noonan, D.J.; Feller, D.R. Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H(2) synthases by ibuprofen, naproxen, and indomethacin. Biochem Pharmacol. 2001, 62(12), 1587-95.
Irvine, J.; Afrose, A.; Islam, N. Formulation and delivery strategies of ibuprofen: challenges and opportunities. Drug Dev Ind Pharm. 2018, 44(2), 173-183.