4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%, Thermo Scientific Chemicals
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4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

4,5-Dimethoxy-2-nitrobenzyl chloroformate, 97%, Thermo Scientific Chemicals

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Quantity:
250 mg
1 g
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Catalog number L14167.MD
also known as L14167-MD
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250 mg
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Chemical Identifiers
CAS42855-00-5
IUPAC Name(4,5-dimethoxy-2-nitrophenyl)methyl carbonochloridate
Molecular FormulaC10H10ClNO6
InChI KeyRWWPKIOWBQFXEE-UHFFFAOYSA-N
SMILESCOC1=CC(COC(Cl)=O)=C(C=C1OC)[N+]([O-])=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to cream to yellow to orange to brown
FormCrystals or powder or crystalline powder
Assay (Titration ex Chloride)≥96.0 to ≤104.0%
Identification (FTIR)Conforms
4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
4,5-Dimethoxy-2-nitrobenzyl chloroformate is used as a reagent for protection of amines, for use in N-protection of bases in nucleotide synthesis, photochemical protecting groups in organic synthesis. It is used as pharmaceutical intermediate.

Solubility
Soluble in methanol, acetone. Reacts with water.

Notes
Moisture and light sensitive. Store away from oxidizing agents, light, water/ moisture, heat, bases.
RUO – Research Use Only

General References:

  1. P Roy, Z Rajfur; D Jones; G Marriott; L Loew; K Jacobson. Local photorelease of caged thymosin beta4 in locomoting keratocytes causes cell turning. Journal of Cell Biology. 2001, 153, (5), 1035-1048.
  2. Adam Frankel; Steven W Millward; Richard W Roberts. Encodamers: Unnatural Peptide Oligomers Encoded in RNA. Chemistry & Biology. 2003, 10, (11), 1043-1050.
  3. Reagent for protection of amines. The group is readily cleaved photolytically: Tetrahedron Lett., 29, 65 (1988). For use in N-protection of bases in nucleotide synthesis, see: J. Org. Chem., 64, 6319 (1999). For reviews of photochemical protecting groups in organic synthesis, see: Synthesis, 1 (1980); Org. Photochem., 9, 225 (1987).