Cryptococcus Antigen Latex Test Kit
Cryptococcus Antigen Latex Test Kit
Thermo Scientific™

Cryptococcus Antigen Latex Test Kit

Rapidly detect polysaccharide antigens associated with Cryptococcus neoformans infection using Cryptococcus Antigen Latex Test Kit.

Have Questions?
Catalog NumberQuantity
R3085150150 Tests/Kit
Catalog number R30851501
Price (TWD)
-
Request A Quote
Quantity:
50 Tests/Kit

Rapidly detect capsular polysaccharide antigens associated with Cryptococcus neoformans infection using Thermo Scientific™ Remel™ Cryptococcus Antigen Latex Test Kit. In 1963, Bloomfield reported detection of cryptococcal polysaccharide (CPS) antigens in serum and CSF of patients with cryptococcosis1. In further testing, investigators reported false-positive reactions in the serum of patients with rheumatoid factor2,3. In 1983, Stockman and Roberts introduced an enzymatic method incorporating protease to eliminate interference factors in serum4.

Cryptococcosis is a systemic infection caused by the yeast, C. neoformans1. The natural reservoirs for C. neoformans are soil and avian feces. Inhalation of yeast cells may lead to a lung infection and possibly disseminated disease. Patients often present with devastating debilitation, especially those with an immunosuppressive syndrome. Because C. neoformans has an unusual affinity for central nervous system tissue, rapid and early detection is essential.

  • Sensitive test
  • Rapid test: Results are obtained within 5 minutes.
  • Easy to identify: A positive test is indicated by any agglutination or clumping and clearing of the test latex immediately after 5 mins rotation step, whereas a negative test is indicated by no agglutination or clumping.
  • Semi-quantitative test: The titer is the reciprocal of the last dilution which produces a positive result (agglutination).

Cryptococcus Antigen Latex Test Kit incorporates the use of latex particles sensitized with murine (mouse) IgM monoclonal antibodies. CPS antigen in patient serum or CSF interacts with sensitized latex particles producing visible agglutination. The use of IgM monoclonal antibodies and treatment of serum with protease reduce the potential for false-positive reactions, eliminating the need to perform a companion control latex test to verify the specificity of results5-6. This test has both diagnostic and prognostic value since progressive disease is usually accompanied by increasing antigen titers. Declining titers are usually associated with clinical improvement, with or without therapy.

Not all products are available for sale in all territories. Please inquire.

Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.

  1. Patterson, T.F. and V.T. Andriole. 1989. Eur. J. Clin. Microbiol. Infect. Dis. 8:457-465.
  2. Kaufman, L. and S. Blumer. 1977. Proc. Int. Conf. Mycoses., Pan Am. Health Org. 356:176-182.
  3. Asznowicz, R., H. Newton-John, and J. Kaldor. 1979. Med. J. Aust. 1:347-349.
  4. Stockman, L. and G.D. Roberts. 1983. J. Clin. Microbiol. 17:945-947.
  5. Gray, L.D. and G.D. Roberts. 1988. J. Clin. Microbiol. 26:2450-2451.
  6. Hamilton, J.R., A. Nobel, D.W. Denning, and D.A. Stevens. 1991. J. Clin. Microbiol. 29:333-339.
Specifications
DescriptionCryptococcus Antigen Latex Test Kit
Includes1 vial test latex; negative control; positive control; low positive control; protease tablet; 10x specimen diluent; reaction cards; dispensing pipette
Quantity50 Tests/Kit
Detectable AnalytesC. neoformans Antigen
Unit SizeEach

Intended use statement 

A latex agglutination test for the detection of Cryptococcus neoformans antigens directly from serum and cerebrospinal fluid (CSF).

Documents & Downloads

Certificates

Safety Data Sheets

Share catalog number, name or link