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Rapidly detect polysaccharide antigens associated with Cryptococcus neoformans infection using Cryptococcus Antigen Latex Test Kit.
Catalog Number | Quantity |
---|---|
R30851501 | 50 Tests/Kit |
Rapidly detect capsular polysaccharide antigens associated with Cryptococcus neoformans infection using Thermo Scientific™ Remel™ Cryptococcus Antigen Latex Test Kit. In 1963, Bloomfield reported detection of cryptococcal polysaccharide (CPS) antigens in serum and CSF of patients with cryptococcosis1. In further testing, investigators reported false-positive reactions in the serum of patients with rheumatoid factor2,3. In 1983, Stockman and Roberts introduced an enzymatic method incorporating protease to eliminate interference factors in serum4.
Cryptococcosis is a systemic infection caused by the yeast, C. neoformans1. The natural reservoirs for C. neoformans are soil and avian feces. Inhalation of yeast cells may lead to a lung infection and possibly disseminated disease. Patients often present with devastating debilitation, especially those with an immunosuppressive syndrome. Because C. neoformans has an unusual affinity for central nervous system tissue, rapid and early detection is essential.
Cryptococcus Antigen Latex Test Kit incorporates the use of latex particles sensitized with murine (mouse) IgM monoclonal antibodies. CPS antigen in patient serum or CSF interacts with sensitized latex particles producing visible agglutination. The use of IgM monoclonal antibodies and treatment of serum with protease reduce the potential for false-positive reactions, eliminating the need to perform a companion control latex test to verify the specificity of results5-6. This test has both diagnostic and prognostic value since progressive disease is usually accompanied by increasing antigen titers. Declining titers are usually associated with clinical improvement, with or without therapy.
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Remel™ and Oxoid™ products are now part of the Thermo Scientific brand.
A latex agglutination test for the detection of Cryptococcus neoformans antigens directly from serum and cerebrospinal fluid (CSF).
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