Produce stable TBDMS derivatives for GC analysis with the Thermo Scientific™ MTBSTFA and MTBSTFA + 1% TBDMCS Silylation Reagent. MTBSTFA derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines with typically >96% yields, and the reaction byproducts are volatile and neutral. TBDMS ethers are 104 times more stable to hydrolysis than the corresponding TMS ethers. Addition of Thermo Scientific™ TBDMCS increases silylation potential.