Cefoxitin sodium salt, 94%

Name: Cefoxitin sodium salt, 94%
SKU: 455280010

Cefoxitin sodium salt, CAS # 33564-30-6, is a β-lactam, second-generation cephalosporin compound showing bactericidal activity against Bacteroides, gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis.

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5 g

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產品號碼 455280010

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化學識別

CAS33564-30-6

IUPAC Namesodium (6R,7S)-3-[(carbamoyloxy)methyl]-7-methoxy-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Molecular FormulaC16H16N3NaO7S2

InChI KeyGNWUOVJNSFPWDD-XMZRARIVSA-M

SMILES[Na+].CO[C@]1(NC(=O)CC2=CC=CS2)[C@H]2SCC(COC(N)=O)=C(N2C1=O)C([O-])=O

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規格

規格表

Appearance (Color)White to cream

Appearance (Form)Powder

Infrared spectrumConforms

Water=<1 %

Specific optical rotation+206° to +214° (20°C, 589 nm) (c= 1, methanol)

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This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Cefoxitin sodium salt is resistant to β-lactamase

• It binds and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall thus interfering with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity

Applications

• Cefoxitin sodium salt is the sodium salt form of cefoxitin derived from cephamycin C

• It is a β-lactam, second-generation cephalosporin compound with bactericidal activity against numerous species such as Bacteroides, gram-negative bacteria, including strains of P. mirabilis, P. vulgaris, E. coli, S. typhimurium, and S. enteritidis

• Cefoxitin increases survival in mice infected with S. aureus, S. pyogenes, and K. pneumoniae

RUO – Research Use Only

General References:

Brogden, R.; Heel, R.; Speight, T.; Avery, G. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1979, 17 (1), 1-37.
Miller, A.K., Celozzi, E., Kong, Y., et al. Cefoxitin, a semisynthetic cephamycin antibiotic: In vivo evaluation. Antimicrob. Agents Chemother. 1974, 5, (1), 33-37.