1-Bromo-3-chloropropane, 99%, Thermo Scientific Chemicals
1-Bromo-3-chloropropane, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

1-Bromo-3-chloropropane, 99%, Thermo Scientific Chemicals

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產品號碼 A11395.0I
亦稱為 A11395-0I
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化學識別
CAS109-70-6
IUPAC Name1-bromo-3-chloropropane
Molecular FormulaC3H6BrCl
InChI KeyMFESCIUQSIBMSM-UHFFFAOYSA-N
SMILESClCCCBr
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規格Specification Sheet規格表
FormLiquid
CommentMaterial sourced in UK and US
Appearance (Color)Clear colorless
Assay (GC)≥98.5% (UK-sourced material)
Refractive Index1.4845-1.4875 @ 20?C (UK-sourced material)
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1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Solubility
Miscible with alcohols, chlorofom and ether. Immiscible with water.

Notes
Incompatible with strong oxidizing, reducing agents, amines, nitrides, azo/diazo compounds, alkali metals and epoxides.
RUO – Research Use Only

General References:

  1. Fan, X.; Sokorai, K. J. Formation of trichloromethane in chlorinated water and fresh-cut produce and as a result of reaction with citric acid. Postharvest Biol. Technol. 2015, 109, 65-72.
  2. Donnier-Maréchal, M.; Carato, P.; Le Broc, D.; Furman, C.; Melnyk, P. Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands. Eur. J. Med. Chem. 2015, 92, 575-582.