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Chloromethyl pivalate, 97%, Thermo Scientific Chemicals
產品號碼: A11967.22
100 g, Each
化學識別
CAS
18997-19-8
IUPAC Name
chloromethyl 2,2-dimethylpropanoate
Molecular Formula
C6H11ClO2
InChI Key
GGRHYQCXXYLUTL-UHFFFAOYSA-N
SMILES
CC(C)(C)C(=O)OCCl
規格
規格表Appearance (Color)
Clear colorless to pale yellow
Identification (FTIR)
Conforms
Assay (GC)
≥96.0%
Refractive Index
1.4145-1.4195 @ 20°C
Form
Liquid
說明
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.
Solubility
Miscible with most organic solvents. Immiscible with water.
Notes
Incompatible with strong oxidizing agents.
Chloromethyl pivalate acts as an intermediate in the synthesis of active pharmaceutical ingredients. It is also involved in the acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine. It serves as a protecting reagent used for the N-protection of amines. It is also employed in the preparation of pivaloyloxy methyl ester of ofloxacin as a prodrug. Further, it is used to prepare sulbactam pivoxil by reaction with sodium salt of sulbactam. In addition to this, it is used as a reagent during the synthesis of an isoindoline-annulated and continuous-flow organic synthesis.
Solubility
Miscible with most organic solvents. Immiscible with water.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
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