Transcription factors are fast becoming promising drug targets, as they bind to and regulate the transcription of genes. The Silencer™ Select Human Transcription Factor siRNA Library targets genes expressing proteins that bind DNA in a sequence-specific manner to control the rate of transcription of genetic information from DNA to messenger RNA. The Silencer Select Human Transcription Factor siRNA Library contains 5457 Ambion™ Silencer Select highly potent and chemically-modified siRNAs targeting 1819 known transcription factors. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). The Silencer Select siRNAs are designed using Thermo Fisher Scientific’s leading design algorithms—along with our novel locked nucleic acid (LNA) chemical modifications, this helps to maximize the efficacy, specificity and potency required for RNAi screening against transcription factors.

• Superior efficacyReduce off target effects by up to 90% due to latest design algorithms and LNA chemical modifications
• Highest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAs
• Dependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic results
• Convenient—Reduce data de-convolution and accelerate target validation with our arrayed format
• Customizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formats

Why use the Silencer Select Human Transcription Factor siRNA Library?
Together with careful bioinformatics selection of gene targets, Silencer Select siRNAs are optimized with latest design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes (learn more). The Silencer Select Human Transcription Factor siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality backed by the best in industry guarantee (learn more about the guarantee).

Silencer Select siRNA libraries empower you with highly potent siRNAs to maximize discovery with even less
Ambion Silencer Select siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potent Silencer Select siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. The Silencer Select Human Transcription Factor siRNA Library contains 0.25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).

Flexibility to meet your workflow needs
Thermo Fisher Scientific offers comprehensive list of pre-defined or custom siRNA libraries to human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.com.