2-Bromo-5-fluorobenzaldehyde is used as a precursor for the synthesis of 5-fluoro-3-substituted benzoxaboroles, which is used in material science as molecular receptors, building block in crystal engineering, as steroid conjugates for molecular imprinting , dyes and biosensors of alpha hydroxyl carboxylic acids. It is also used in the synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-one by reacting with 2-amino-N'-arylbenzohydrazide in the presence of Copper(I) bromide by the Ullmann-type reaction.
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Applications
2-Bromo-5-fluorobenzaldehyde is used as a precursor for the synthesis of 5-fluoro-3-substituted benzoxaboroles, which is used in material science as molecular receptors, building block in crystal engineering, as steroid conjugates for molecular imprinting , dyes and biosensors of alpha hydroxyl carboxylic acids. It is also used in the synthesis of 5-arylindazolo[3,2-b]quinazolin-7(5H)-one by reacting with 2-amino-N′-arylbenzohydrazide in the presence of Copper(I) bromide by the Ullmann-type reaction.
Solubility
Soluble in methanol.
Notes
Air sensitive. Keep container tightly closed in a cool, dry and well-ventilated place.
RUO – Research Use Only
General References:
- Sene, S.; Berthomieu, D.; Donnadieu, B.; Richeter, S.; Vezzani, J.; Granier, D.; Bégu, S.; Mutin, H.; Gervais, C.; Laurencin, D. A combined experimental-computational study of benzoxaborole crystal structures. CrystEngComm 2014, 16 (23), 4999-5011.
- Tureski, R. E.; Tanski, J. M. 2-Bromo-5-fluoro¬benzaldehyde. Acta Crystallogr. Sect. E: Struct. Rep. Online 2013, 69 (8), 1246.