Carbenicillin disodium salt, Thermo Scientific Chemicals

Name: Carbenicillin disodium salt, Thermo Scientific Chemicals
SKU: J61949.03

Carbenicillin disodium salt, CAS # 4800-94-6, is the disodium salt form of carbenicillin, a semisynthetic compound with broad-spectrum antibacterial and β-lactamase-resistant activities.

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產品號碼 J61949.03

亦稱為 J61949-03

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化學識別

CAS4800-94-6

IUPAC Namedisodium (2S,5R,6R)-6-(2-carboxylato-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Molecular FormulaC17H16N2Na2O6S

InChI KeyRTYJTGSCYUUYAL-YCAHSCEMSA-L

SMILES[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)C3=CC=CC=C3)C(=O)N2[C@H]1C([O-])=O

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規格

規格表

Assay (special)Chromatographic purity: ≥ 92.0%

pH6.5 to 8.0

FormCrystalline powder

Water Content (Karl Fischer Titration)≤ 6.0 %

Appearance (Color)White to cream

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Carbenicillin disodium salt is a water-soluble antibiotic which is effective against gram-negative bacteria.Carbenicillin disodium salt is widely utilized as an antibiotic which is used to control bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. It has been involved in the study of the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Carbenicillin disodium salt is a semisynthetic compound with antibacterial and β-lactamase-resistant activities and is effective against gram-negative bacteria
In in vitro studies, carbenicillin disodium salt can totally suppress the proliferation of Agrobacterium

Application

Due to its antibacterial activity, this compound can be used to control bacterial cell wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. This can lead to incomplete bacterial cell wall synthesis to eventually cause cell lysis
It has also been used in studies to evaluate the role of penicillin-sensitive transpeptidases in cell wall biosynthesis

RUO – Research Use Only

General References:

Cole, M. R.; Hobden, J. A.; Warner, I. M. Recycling Antibiotics into GUMBOS: A New Combination Strategy to Combat Multi-Drug-Resistant Bacteria. Molecules 2015, 20 (4), 6466-6487.
Sonopo, M. S.; Venter, K.; Boyle, G.; Winks, S.; Painter, B. M.; Zeevaart, J. R. Carbon-14 radiolabeling and in vivo biodistribution of a potential anti-TB compound. J. Labelled Comp. Radiopharm. 2015, 58 (2), 23-29.