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DL-Thiorphan, Thermo Scientific Chemicals
規格
Chemical Name or MaterialDL-Thiorphan
CAS76721-89-6
Melting Point135°C to 137°C
ColorWhite
Recommended StorageStore at -20°C
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Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 ?M) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). Neprilysin is overexpressed in many forms of cancer and may play a role in protecting against Alzheimer’s disease.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 μM) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). N
Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 μM) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). N
RUO – Research Use Only
General References:
- Amantini C et al. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. J Pharmacol Exp Ther . 2008, 327, (1), 215-25.
- Medja F et al. Thiorphan, a neutral endopeptidase inhibitor used for diarrhoea, is neuroprotective in newborn mice. Brain . 2006, 129, (pt 12), 3209-23.