Product References
BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas.
eLife
Huchede P,Meyer S,Berthelot C,Hamadou M,Bertrand-Chapel A,Rakotomalala A,Manceau L,Tomine J,Lespinasse N,Lewandowski P,Cordier-Bussat M,Broutier L,Dutour A,Rochet I,Blay JY,Degletagne C,Attignon V,Montero-Carcaboso A,Le Grand M,Pasquier E,Vasiljevic A,Gilardi-Hebenstreit P,Meignan S,Leblond P,Ribes V,Cosset E,Castets M
120-03P was used in Cell Culture to suggest a generic oncogenic role for the BMP pathway in gliomagenesis of pDMG and pave the way for specific targeting of downstream effectors mediating the K27M/BMP crosstalk.
Mon Oct 07 00:00:00 UTC 2024
Protocol for capturing trophectoderm stem cells reflecting the blastocyst stage.
STAR protocols
Seong J,Rivron NC
120-03P was used in Cell Culture to captures trophectoderm stem cells with enhanced transcriptomic similarity to the blastocyst trophectoderm and self-renewal, reduced differentiation.
Thu Mar 16 00:00:00 UTC 2023
Generation of multilineage liver organoids with luminal vasculature and bile ducts from human pluripotent stem cells via modulation of Notch signaling.
Stem cell research & therapy
Kim HJ,Kim G,Chi KY,Kim H,Jang YJ,Jo S,Lee J,Lee Y,Woo DH,Han C,Kim SK,Park HJ,Kim JH
120-03P was used in Cell Culture to demonstrate that mLOs can reproduce parenchymal and non-parenchymal cell interactions and suggest that their application can advance the precise modeling of liver diseases in vitro.
Fri Feb 03 00:00:00 UTC 2023
Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials.
iScience
Ishikawa T,Ogawa T,Shiihara M,Usubuchi H,Omori Y,Hirose K,Itoh T,Yoshida T,Nakanome A,Okoshi A,Higashi K,Ishii R,Rokugo M,Wakamori S,Okamura Y,Kinoshita K,Katori Y,Furukawa T
120-03 was used in Cell Culture to establish a translational model for testing molecular-targeted therapies by combining patient-derived organoids and genomic analyses of Salivary gland cancers.
Fri May 19 00:00:00 UTC 2023
Recapitulating hepatitis E virus-host interactions and facilitating antiviral drug discovery in human liver-derived organoids.
Science advances
Li P,Li Y,Wang Y,Liu J,Lavrijsen M,Li Y,Zhang R,Verstegen MMA,Wang Y,Li TC,Ma Z,Kainov DE,Bruno MJ,de Man RA,van der Laan LJW,Peppelenbosch MP,Pan Q
Fri Jan 21 00:00:00 UTC 2022
Generation, Maintenance and HBV Infection of Human Liver Organoids.
Bio-protocol
Romal S,Hossain T,Mahmoudi T
120-03P was used in Cell Culture to propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis.
Sun Mar 20 00:00:00 UTC 2022
Context-dependent tumor-suppressive BMP signaling in diffuse intrinsic pontine glioma regulates stemness through epigenetic regulation of CXXC5.
Nature cancer
Sun Y,Yan K,Wang Y,Xu C,Wang D,Zhou W,Guo S,Han Y,Tang L,Shao Y,Shan S,Zhang QC,Tang Y,Zhang L,Xi Q
120-03P was used in In vitro experiments to show how BMP signaling impacts diffuse intrinsic pontine glioma (DIPG) and identifies the potent antitumor efficacy of Dacinostat for DIPG.
Thu Sep 01 00:00:00 UTC 2022
Single-cell RNA sequencing reveals PDGFRα+ stromal cell subpopulations that promote proacinar cell differentiation in embryonic salivary gland organoids.
Development (Cambridge, England)
Moskwa N,Mahmood A,Nelson DA,Altrieth AL,Forni PE,Larsen M
120-03P was used in Tissue/organ culture to performe single-cell RNA-sequencing and identified multiple stromal cell subsets, including Pdgfra+ stromal subsets expressing both Fgf2 and Fgf10.
Tue Mar 15 00:00:00 UTC 2022
Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse.
The Journal of experimental medicine
Guo D,Wang Y,Cheng Y,Liao S,Hu J,Du F,Xu G,Liu Y,Cai KQ,Cheung M,Wainwright BJ,Lu QR,Zhao Y,Yang ZJ
Mon Sep 06 00:00:00 UTC 2021
Bone morphogenetic protein induces bone invasion of melanoma by epithelial-mesenchymal transition via the Smad1/5 signaling pathway.
Laboratory investigation; a journal of technical methods and pathology
Gao J,Muroya R,Huang F,Nagata K,Shin M,Nagano R,Tajiri Y,Fujii S,Yamaza T,Aoki K,Tamura Y,Inoue M,Chishaki S,Kukita T,Okabe K,Matsuda M,Mori Y,Kiyoshima T,Jimi E
Mon Nov 01 00:00:00 UTC 2021
Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.
American journal of physiology. Gastrointestinal and liver physiology
Blutt SE,Crawford SE,Bomidi C,Zeng XL,Broughman JR,Robertson M,Coarfa C,Tessier MEM,Savidge T,Hollinger FB,Curley SA,Donowitz M,Estes MK
Wed Sep 01 00:00:00 UTC 2021
Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency.
Nature communications
Shin S,Zhou H,He C,Wei Y,Wang Y,Shingu T,Zeng A,Wang S,Zhou X,Li H,Zhang Q,Mo Q,Long J,Lan F,Chen Y,Hu J
Fri May 21 00:00:00 UTC 2021
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Cell death & disease
Clark MP,Huynh T,Rao S,Mackiewicz L,Mason H,Romal S,Stutz MD,Ahn SH,Earnest L,Sozzi V,Littlejohn M,Tran BM,Wiedemann N,Vincan E,Torresi J,Netter HJ,Mahmoudi T,Revill P,Pellegrini M,Ebert G
Wed Jun 23 00:00:00 UTC 2021
Testicular somatic cell-like cells derived from embryonic stem cells induce differentiation of epiblasts into germ cells.
Communications biology
Rore H,Owen N,Piña-Aguilar RE,Docherty K,Sekido R
Mon Jun 28 00:00:00 UTC 2021
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.
Nature communications
Saraswat D,Shayya HJ,Polanco JJ,Tripathi A,Welliver RR,Pol SU,Seidman RA,Broome JE,O'Bara MA,van Kuppervelt TH,Phillips JJ,Dutta R,Sim FJ
Fri Mar 26 00:00:00 UTC 2021
Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.
Nature communications
Saraswat D,Shayya HJ,Polanco JJ,Tripathi A,Welliver RR,Pol SU,Seidman RA,Broome JE,O'Bara MA,van Kuppervelt TH,Phillips JJ,Dutta R,Sim FJ
Fri Mar 26 00:00:00 UTC 2021
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium.
Cell stem cell
Jacob F,Pather SR,Huang WK,Zhang F,Wong SZH,Zhou H,Cubitt B,Fan W,Chen CZ,Xu M,Pradhan M,Zhang DY,Zheng W,Bang AG,Song H,Carlos de la Torre J,Ming GL
Thu Dec 03 00:00:00 UTC 2020
Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism.
bioRxiv : the preprint server for biology
Jacob F,Pather SR,Huang WK,Wong SZH,Zhou H,Zhang F,Cubitt B,Chen CZ,Xu M,Pradhan M,Zhang DY,Zheng W,Bang AG,Song H,de A Torre JC,Ming GL
Tue Jul 28 00:00:00 UTC 2020
A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.
Advanced healthcare materials
Klotz BJ,Oosterhoff LA,Utomo L,Lim KS,Vallmajo-Martin Q,Clevers H,Woodfield TBF,Rosenberg AJWP,Malda J,Ehrbar M,Spee B,Gawlitta D
Tue Oct 01 00:00:00 UTC 2019
Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Wang C,Xiao F,Gan Y,Yuan W,Zhai Z,Jin T,Chen X,Zhang X
120-03 was used in Cell Culture to suggest that Chordin is a potential target for improving osteogenesis and bone nonunion therapy and that responsive and non-toxic cationic polyimines such as PSI are therapeutically feasible carriers for the packaging and delivery of Chordin siRNA to hBMSCs.
Mon Jun 25 00:00:00 UTC 2018
