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            • Proteins & Peptides ›
            • M-CSF Proteins
            The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

            Gibco

            Human M-CSF Recombinant Protein, PeproTech®

            544 References
            View all (9) M-CSF proteins
            Datasheet
            Tech Support
            Datasheet
            Tech Support

            Cite Human M-CSF Recombinant Protein, PeproTech®

            • Testing Data (2)
            Application
            Human M-CSF Protein in Functional Assay (Functional)
            Group 53 Created with Sketch.

            FIGURE: 1 / 2

            Human M-CSF Protein (300-25-50UG) in Functional

            Bioassay analysis of Human M-CSF Recombinant Protein, PeproTech® (Product # 300-25-1MG).
            View Product

            Human M-CSF Protein in Functional Assay (Functional)
            Human M-CSF Protein in Functional Assay (Functional)

            Product Details

            300-25-50UG

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            Assay-dependent
            -

            ELISA (ELISA)

            Assay-dependent
            -

            Functional Assay (Functional)

            Assay-dependent
            -

            In vitro Assay (IV)

            -
            View 476 publications 476 publications

            Miscellaneous PubMed (Misc)

            -
            View 68 publications 68 publications
            Product Specifications

            Species

            Human

            Published species

            Bovine, Cat, Dog, Hamster, Human, Mouse, Non-human primate, Rabbit, Rat, Virus

            Expression System

            E. coli

            Amino acid sequence

            MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

            Molecular weight

            36.8 kDa

            Class

            Recombinant

            Type

            Protein

            Purity

            ≥ 98% by SDS-PAGE gel and HPLC analyses.

            Endotoxin concentration

            <1 EU/µg

            Activity

            The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NSF-60 cells ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 10^6 units/mg.

            Conjugate

            Unconjugated

            Form

            Lyophilized

            Purification

            purified

            Contains

            no preservative

            Storage conditions

            -20°C

            Shipping conditions

            Ambient

            Product Specific Information

            Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.

            This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

            Target Information

            M-CSF (Macrophage colony-stimulating factor, CSF-1) is a survival factor essential for the proliferation and development of monocytes, macrophages, and osteoclast progenitor cells. M-CSF also induces VEGF (vascular endothelial growth factor) secretion by macrophages, thereby mediating mobilization of endothelial progenitor cells and neovascularization. M-CSF is present as several bioactive isoforms that differ in potency and stability. The full-length protein is synthesized as a membrane-spanning protein that can be expressed on the cell surface or further cleaved and modified in the secretory vesicle. Further, M-CSF is a disulfide-bonded homodimer which is processed into one of two isoforms, a glycoprotein or a proteoglycan that has been modified by the addition of chondroitin sulfate to each subunit. Binding of M-CSF to its receptor, c-Fms (CSF-1R or CD115) induces dimerization of the receptor followed by internalization and degradation of the complex. Functionally, M-CSF is known to stimulate differentiation of hematopoietic stem cells to monocyte-macrophage cell populations in culture. M-CSF acts through the CSF receptor 1. Although human M-CSF shows activity on mouse cells, mouse CSF shows no activity on human cells.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            Bioinformatics

            Protein Aliases: colony stimulating factor 1 (macrophage); CSF-1; H-MCSF; Lanimostim; M-MCSF; macrophage colony stimulating factor 1; Macrophage colony-stimulating factor 1; MGC31930; PG-M-CSF; Proteoglycan macrophage colony-stimulating factor

            View more View less

            Gene Aliases: CSF-1; CSF1; MCSF

            View more View less

            UniProt ID: (Human) P09603

            View more View less

            Entrez Gene ID: (Human) 1435

            View more View less

            It has to be done as per old AB suggested Products section.
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