Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 14 amino acids near the carboxy terminus of human BFAR.
PEP-1008 can be used as a blocking peptide with polyclonal antibody PA5-20894.
The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
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Protein Aliases: bifunctional apoptosis inhibitor; Bifunctional apoptosis regulator; RING finger protein 47
Gene Aliases: BAR; BFAR; RNF47
UniProt ID: (Human) Q9NZS9
Entrez Gene ID: (Human) 51283
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