Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 18 amino acid peptide near the amino terminus of human DELE.
PEP-1445 can be used as a blocking peptide with polyclonal antibody PA5-34403.
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; Death ligand signal enhancer; DELE1(L)
Gene Aliases: DELE; DELE1; KIAA0141
UniProt ID: (Human) Q14154
Entrez Gene ID: (Human) 9812
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support