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Invitrogen
Human DOCK4 (aa 1723-1788) Control Fragment Recombinant Protein
Product Details
RP-107821
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
CSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (100%), Rat (100%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67177. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The DOCK4 gene encodes the dedicator of cytokinesis 4 protein, a member of the DOCK family, which functions as a guanine nucleotide exchange factor (GEF) for small Rho GTPases, specifically Rac1 and Rap1. DOCK4 is critical for regulating various cellular processes, including cell migration, polarity, and cytoskeletal organization. It plays a significant role in maintaining the integrity of endothelial barriers and mediating intercellular junctions. Mutations or altered expression of DOCK4 have been implicated in cancer progression, particularly in tumor metastasis and invasion, by affecting the adhesion and migration of cancer cells. Additionally, DOCK4 is involved in neurodevelopmental processes and has been associated with psychiatric disorders, reflecting its importance in brain function and development. Understanding the roles of DOCK4 in both health and disease could provide insights into therapeutic strategies for cancer and neurological disorders where these pathways are disrupted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dedicator of cytokinesis protein 4
Gene Aliases: DOCK4; KIAA0716
UniProt ID: (Human) Q8N1I0
Entrez Gene ID: (Human) 9732
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