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Invitrogen
Human ERR Beta, Ligand Binding Domain, GST Tag Recombinant Protein
Product Details
PV4802
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
204-433
Tag
GST-tag
Class
Recombinant
Type
Protein
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
proprietary buffer
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
Estrogen Related Receptor beta, Ligand Binding Domain (ERR beta-LBD) is a 54.29 kDa recombinant human protein (amino acids 204-433) expressed as a GST fusion protein in baculovirus-infected insect cells. ERR beta was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Binding Domain, GST-Tagged, Recombinant Human
Protein Form: Ligand Binding Domain
Target Information
ESRRB (steroid hormone receptor ERR2) plays a role in maintenance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation ESRRB interacts with KDM1A by directly binding to enhancer sites of ELF5 and EOMES and activates their transcription leading to self-renewal of trophoblast stem cells. ESSRB also regulates expression of multiple rod-specific genes and is required for survival of this cell type. Defects in the gene can cause deafness, autosomal recessive, 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ERR beta-2; ERR-beta; ERRbeta; ERRbeta-2; Estrogen receptor-like 2; estrogen-related nuclear receptor beta; Estrogen-related receptor beta; nuclear receptor ERRB2; Nuclear receptor subfamily 3 group B member 2; orphan nuclear receptor; Steroid hormone receptor ERR2
Gene Aliases: DFNB35; ERR2; ERRb; ERRB2; ESRL2; ESRRB; NR3B2
UniProt ID: (Human) O95718
Entrez Gene ID: (Human) 2103
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