Product References
Induced pluripotent stem cell model revealed impaired neurovascular interaction in genetic small vessel disease Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy.
Frontiers in cellular neuroscience
Zhang W,Zhao X,Qi X,Kimber SJ,Hooper NM,Wang T
100-18C was used in Cell Culture to establish induced pluripotent stem cell (iPSC) models from Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy patients and differentiated the iPSCs into the major neurovascular unit cell types including brain microvascular endothelial-like cells (BMECs), vascular mural cells (MCs), astrocytes and cortical projection neurons.
Wed Feb 14 00:00:00 UTC 2024
Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study.
Cell reports. Medicine
Wang HM,Zhang CY,Peng KC,Chen ZX,Su JW,Li YF,Li WF,Gao QY,Zhang SL,Chen YQ,Zhou Q,Xu C,Xu CR,Wang Z,Su J,Yan HH,Zhang XC,Chen HJ,Wu YL,Yang JJ
100-18C was used in Tissue/organ culture to generate 214 cancer organoids from 107 patients, of which 212 are lung cancer organoids, primarily derived from malignant serous effusions.
Tue Feb 21 00:00:00 UTC 2023
The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice.
Oncogenesis
Schoof M,Epplen GD,Walter C,Ballast A,Holdhof D,Göbel C,Neyazi S,Varghese J,Albert TK,Kerl K,Schüller U
100-18C was used in Cell Culture to demonstrate the oncogenic potential of a combined loss of function of cAMP response element-binding protein binding protein and overexpression of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog in this cell population.
Wed Jul 05 00:00:00 UTC 2023
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Cell stem cell
Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S
100-18C was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
Thu Apr 07 00:00:00 UTC 2022
Generation and Cultivation of Transgene-Free Macaque and Baboon iPSCs Under Chemically Defined Conditions.
Methods in molecular biology (Clifton, N.J.)
Rodríguez-Polo I,Stauske M,Behr R
100-18C was used in Cell Culture to provide a robust protocol for the generation of transgene-free Old World monkey (and human) iPSCs and long-term cultivation under chemically defined conditions which was applied to generate human, baboon (Papio anubis), rhesus (Macaca mulatta), and cynomolgus macaque (Macaca fascicularis) iPSCs from skin fibroblasts.
Thu Jun 23 00:00:00 UTC 2022
GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer.
Cell reports
McKinney AM,Mathur R,Stevers NO,Molinaro AM,Chang SM,Phillips JJ,Costello JF
100-18C was used in Cell Culture to study whether the role of epidermal growth factor receptor (EGFR) amplification to drive proliferation and telomerase reverse transcriptase promoter (TERTp) mutations underlying telomerase reactivation through recruitment of GA-binding protein (GABP) are functionally connected in cancer.
Tue Sep 20 00:00:00 UTC 2022
Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells.
Cell stem cell
Pham TXA,Panda A,Kagawa H,To SK,Ertekin C,Georgolopoulos G,van Knippenberg SSFA,Allsop RN,Bruneau A,Chui JS,Vanheer L,Janiszewski A,Chappell J,Oberhuemer M,Tchinda RS,Talon I,Khodeer S,Rossant J,Lluis F,David L,Rivron N,Balaton BP,Pasque V
100-18C was used in Cell Culture to investigate the mechanisms involved in differentiation of naive human pluripotent stem cells into EXM cells.
Thu Sep 01 00:00:00 UTC 2022
Tissue Niche Miniature of Glioblastoma Patient Treated with Nano-Awakeners to Induce Suicide of Cancer Stem Cells.
Advanced healthcare materials
Yoon SJ,Baek S,Yu SE,Jo E,Lee D,Shim JK,Choi RJ,Park J,Moon JH,Kim EH,Chang JH,Lee JB,Park JS,Sung HJ,Kang SG
100-18C was used in Tissue/organ culture to suggest a GBM clinic-driven avatar platform and mechanism-learned nanotherapy for translation.
Tue Nov 01 00:00:00 UTC 2022
A spatiotemporal steroidogenic regulatory network in human fetal adrenal glands and gonads.
Frontiers in endocrinology
Wang Y,Guo B,Guo Y,Qi N,Lv Y,Ye Y,Huang Y,Long X,Chen H,Su C,Zhang L,Zhang Q,Li M,Liao J,Yan Y,Mao X,Zeng Y,Jiang J,Chen Z,Guo Y,Gao S,Cheng J,Jiang Y,Mo Z
100-18C was used in Cell Culture to study human fetal adrenal glands through single-cell transcriptome techniques, revealing their role in steroid synthesis and sexual differentiation during early gestational weeks.
Tue Dec 06 00:00:00 UTC 2022
Renalase and its receptor, PMCA4b, are expressed in the placenta throughout the human gestation.
Scientific reports
Wang M,Silva T,Toothaker JM,McCourt BT,Shugrue C,Desir G,Gorelick F,Konnikova L
100-18C was used in Cell Culture to examine the potential role of renalase in placental development.
Wed Mar 23 00:00:00 UTC 2022
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-18C was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
Cell stem cell
Huang L,Desai R,Conrad DN,Leite NC,Akshinthala D,Lim CM,Gonzalez R,Muthuswamy LB,Gartner Z,Muthuswamy SK
100-18C was used in Tissue/organ culture to report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas.
Thu Jun 03 00:00:00 UTC 2021
APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ramakrishna S,Jhaveri V,Konings SC,Nawalpuri B,Chakraborty S,Holst B,Schmid B,Gouras GK,Freude KK,Muddashetty RS
100-18C was used in Cell Culture to show that the defective protein synthesis mediated by APOE4 is closely linked to the perturbation of calcium homeostasis caused by APOE4 in neurons.
Wed Oct 20 00:00:00 UTC 2021
Cell-assembled extracellular matrix (CAM) sheet production: Translation from using human to large animal cells.
Journal of tissue engineering
Torres Y,Gluais M,Da Silva N,Rey S,Grémare A,Magnan L,Kawecki F,L'Heureux N
100-18C was used in Cell Culture to compare the tissue development and composition of cell-assembled extracellular matrix sheets between different sources of skin fibroblasts, including ovine and human fibroblasts, for use in production of tissue-engineered vascular grafts.
Thu May 02 00:00:00 UTC 2024
Cell-assembled extracellular matrix (CAM) sheet production: Translation from using human to large animal cells.
Journal of tissue engineering
Torres Y,Gluais M,Da Silva N,Rey S,Grémare A,Magnan L,Kawecki F,L'Heureux N
100-18C was used in Cell Culture to compare the tissue development and composition of cell-assembled extracellular matrix sheets between different sources of skin fibroblasts, including ovine and human fibroblasts, for use in production of tissue-engineered vascular grafts.
Thu May 02 00:00:00 UTC 2024
Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow.
Cell reports
Magod P,Mastandrea I,Rousso-Noori L,Agemy L,Shapira G,Shomron N,Friedmann-Morvinski D
Tue Aug 03 00:00:00 UTC 2021
Leukemia Inhibitory Factor Is Required for Subventricular Zone Astrocyte Progenitor Proliferation and for Prokineticin-2 Production after a Closed Head Injury in Mice.
Neurotrauma reports
Frondelli MJ,Levison SW
100-18C was used in Cell Culture to investigate astrocytes in closed head injury.
Tue Jul 06 00:00:00 UTC 2021
Modeling of the Human Bone Environment: Mechanical Stimuli Guide Mesenchymal Stem Cell-Extracellular Matrix Interactions.
Materials (Basel, Switzerland)
Pereira AR,Lipphaus A,Ergin M,Salehi S,Gehweiler D,Rudert M,Hansmann J,Herrmann M
100-18C was used in Cell Culture to apply a bioreactor system where human bone-marrow hMSCs are seeded in human femoral head-derived decellularized bone scaffolds and subjected to dynamic culture to provide a foundation for exploring the early effects of external mechanical stimuli on hMSC behavior in a biologically meaningful in vitro environment.
Sat Aug 07 00:00:00 UTC 2021
Isothermal microcalorimetry measures UCP1-mediated thermogenesis in mature brite adipocytes.
Communications biology
Bokhari MH,Halleskog C,Åslund A,Boulet N,Casadesús Rendos E,de Jong JMA,Csikasz R,Amri EZ,Shabalina I,Bengtsson T
Tue Sep 21 00:00:00 UTC 2021
Cohesin-protein Shugoshin-1 controls cardiac automaticity via HCN4 pacemaker channel.
Nature communications
Liu D,Song AT,Qi X,van Vliet PP,Xiao J,Xiong F,Andelfinger G,Nattel S
Wed May 05 00:00:00 UTC 2021
Active constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice.
BMC complementary medicine and therapies
Wang XF,Xiao HH,Wu YT,Kong L,Chen JC,Yang JX,Hu XL
100-18C was used in Cell Culture to investigate the effects of three active constituents [3,6'-disinapoyl sucrose (DISS), onjisaponin B (OB) and tenuifolin (TEN)] of Polygala tenuifolia (PT) on the proliferation and differentiation of neural stem cells (NSCs) to identify the potential active constituent of PT promoting hippocampal neurogenesis.
Mon Oct 25 00:00:00 UTC 2021
A high-throughput microfluidic bilayer co-culture platform to study endothelial-pericyte interactions.
Scientific reports
Rogers MT,Gard AL,Gaibler R,Mulhern TJ,Strelnikov R,Azizgolshani H,Cain BP,Isenberg BC,Haroutunian NJ,Raustad NE,Keegan PM,Lech MP,Tomlinson L,Borenstein JT,Charest JL,Williams C
Wed Jun 09 00:00:00 UTC 2021
Coordination of germ layer lineage choice by TET1 during primed pluripotency.
Genes & development
Luo X,van der Veer BK,Sun L,Bartoccetti M,Boretto M,Vankelecom H,Khoueiry R,Koh KP
100-18C was used in Cell Culture to study how Tet1 plays a pivotal role upstream of germ layer lineage bifurcation and provide mechanistic information for epigenetic integration of pluripotency and signal-induced differentiation cues.
Wed Apr 01 00:00:00 UTC 2020
ROS and Lipid Droplet accumulation induced by high glucose exposure in healthy colon and Colorectal Cancer Stem Cells.
Genes & diseases
Tirinato L,Pagliari F,Di Franco S,Sogne E,Marafioti MG,Jansen J,Falqui A,Todaro M,Candeloro P,Liberale C,Seco J,Stassi G,Di Fabrizio E
100-18C was used in Tissue/organ culture to investigate the gene modulations following the HG treatment and found out that the healthy cell gene profile was the most affected.
Tue Dec 01 00:00:00 UTC 2020
3D Cell Culture Models Demonstrate a Role for FGF and WNT Signaling in Regulation of Lung Epithelial Cell Fate and Morphogenesis.
Frontiers in cell and developmental biology
Rabata A,Fedr R,Soucek K,Hampl A,Koledova Z
100-18C was used in Cell Culture to present lung 3D cell culture models as useful tools to study the role and interplay of signaling pathways in postnatal lung development and homeostasis, and we reveal distinct roles for FGF ligands in regulation of mouse lung morphogenesis and differentiation ex vivo.
Mon Sep 28 00:00:00 UTC 2020
2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche.
Communications biology
Koike N,Kota R,Naito Y,Hayakawa N,Matsuura T,Hishiki T,Onishi N,Fukada J,Suematsu M,Shigematsu N,Saya H,Sampetrean O
Mon Aug 17 00:00:00 UTC 2020
Visfatin Enhances Breast Cancer Progression through CXCL1 Induction in Tumor-Associated Macrophages.
Cancers
Wang YY,Chen HD,Lo S,Chen YK,Huang YC,Hu SC,Hsieh YC,Hung AC,Hou MF,Yuan SF
100-18C was used in In vitro experiments to demonstrate that visfatin enhanced breast cancer progression via pERK/CXCL1 induction in macrophages.
Thu Nov 26 00:00:00 UTC 2020
FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits.
Cell stem cell
Bowers M,Liang T,Gonzalez-Bohorquez D,Zocher S,Jaeger BN,Kovacs WJ,Röhrl C,Cramb KML,Winterer J,Kruse M,Dimitrieva S,Overall RW,Wegleiter T,Najmabadi H,Semenkovich CF,Kempermann G,Földy C,Jessberger S
100-18C was used in Cell Culture to investigate lipid metabolism and cognitive function in neural stem/progenitor cells and human embryonic stem cells.
Thu Jul 02 00:00:00 UTC 2020
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
Acta neuropathologica communications
Findakly S,Choudhury A,Daggubati V,Pekmezci M,Lang UE,Raleigh DR
100-18C was used in Cell Culture to investigate mechanisms of ciliary Hedgehog signaling in meningioma using tissue microarrays containing 154 human meningioma samples, NanoString transcriptional profiling, primary meningioma cells, pharmacology, and CRISPR interference.
Mon Jul 20 00:00:00 UTC 2020
Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors.
Nature communications
Hosaka K,Yang Y,Seki T,Du Q,Jing X,He X,Wu J,Zhang Y,Morikawa H,Nakamura M,Scherzer M,Sun X,Xu Y,Cheng T,Li X,Liu X,Li Q,Liu Y,Hong A,Chen Y,Cao Y
Fri Jul 24 00:00:00 UTC 2020
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells.
Journal of visualized experiments : JoVE
Jeon K,Park K,Jetten AM
100-18C was used in In vitro experiments to study inefficient and time-cosuming standard approaches for human embryonic stem cell (hESC) culture using colony type culture to maintain undifferentiated hESCs and embryoid body (EB) and rosette formation for differentiation into different germ layers to instead present a single-cell culture method using hESCs instead of a colony-type culture.
Sat Jan 18 00:00:00 UTC 2020
Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.
Nature communications
Magill ST,Vasudevan HN,Seo K,Villanueva-Meyer JE,Choudhury A,John Liu S,Pekmezci M,Findakly S,Hilz S,Lastella S,Demaree B,Braunstein SE,Bush NAO,Aghi MK,Theodosopoulos PV,Sneed PK,Abate AR,Berger MS,McDermott MW,Lim DA,Ullian EM,Costello JF,Raleigh DR
Wed Sep 23 00:00:00 UTC 2020
NLRP7 plays a functional role in regulating BMP4 signaling during differentiation of patient-derived trophoblasts.
Cell death & disease
Alici-Garipcan A,Özçimen B,Süder I,Ülker V,Önder TT,Özören N
Wed Aug 19 00:00:00 UTC 2020
Anti-apoptotic Mutations Desensitize Human Pluripotent Stem Cells to Mitotic Stress and Enable Aneuploid Cell Survival.
Stem cell reports
Zhang J,Hirst AJ,Duan F,Qiu H,Huang R,Ji Y,Bai L,Zhang F,Robinson D,Jones M,Li L,Wang P,Jiang P,Andrews PW,Barbaric I,Na J
Tue Mar 05 00:00:00 UTC 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 UTC 2019
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness.
Cell reports
Sabelström H,Petri R,Shchors K,Jandial R,Schmidt C,Sacheva R,Masic S,Yuan E,Fenster T,Martinez M,Saxena S,Nicolaides TP,Ilkhanizadeh S,Berger MS,Snyder EY,Weiss WA,Jakobsson J,Persson AI
100-18C was used in Sample Preparation to conclude that reversal of an ERK1/2-miR-124-SOX9 axis induces a neuronal phenotype and that enforcing neuronal differentiation represents a therapeutic strategy to improve outcomes in GBM.
Tue Aug 20 00:00:00 UTC 2019
Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness.
Cell reports
Sabelström H,Petri R,Shchors K,Jandial R,Schmidt C,Sacheva R,Masic S,Yuan E,Fenster T,Martinez M,Saxena S,Nicolaides TP,Ilkhanizadeh S,Berger MS,Snyder EY,Weiss WA,Jakobsson J,Persson AI
100-18C was used in Sample Preparation to conclude that reversal of an ERK1/2-miR-124-SOX9 axis induces a neuronal phenotype and that enforcing neuronal differentiation represents a therapeutic strategy to improve outcomes in GBM.
Tue Aug 20 00:00:00 UTC 2019
Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition.
Cell death discovery
da Hora CC,Pinkham K,Carvalho L,Zinter M,Tabet E,Nakano I,Tannous BA,Badr CE
Mon Sep 28 00:00:00 UTC 2020
Preparation and Co-Culture of iPSC-Derived Dopaminergic Neurons and Astrocytes.
Current protocols in cell biology
de Rus Jacquet A
Sun Dec 01 00:00:00 UTC 2019
Chromatin analysis in human early development reveals epigenetic transition during ZGA.
Nature
Wu J,Xu J,Liu B,Yao G,Wang P,Lin Z,Huang B,Wang X,Li T,Shi S,Zhang N,Duan F,Ming J,Zhang X,Niu W,Song W,Jin H,Guo Y,Dai S,Hu L,Fang L,Wang Q,Li Y,Li W,Na J,Xie W,Sun Y
Tue May 01 00:00:00 UTC 2018
Fibroblast growth factor-2, but not the adipose tissue-derived stromal cells secretome, inhibits TGF-β1-induced differentiation of human cardiac fibroblasts into myofibroblasts.
Scientific reports
Liguori TTA,Liguori GR,Moreira LFP,Harmsen MC
Fri Nov 09 00:00:00 UTC 2018
Cancer Stem Cell Migration in Three-Dimensional Aligned Collagen Matrices.
Current protocols in stem cell biology
Ray A,Morford RK,Provenzano PP
100-18C was used in Cell Culture to study the interactions of heterogeneous populations of cancer cells that include the stem/progenitor-like cancer stem cell subpopulation and aligned collagen networks is critical to our understanding of carcinoma dissemination and provide a platform to study cancer stem cell migration in 3-D anisotropic collagen with real-time visualization of cellular interactions with the fibrous matrix.
Wed Aug 01 00:00:00 UTC 2018
3D bio-printed scaffold-free nerve constructs with human gingiva-derived mesenchymal stem cells promote rat facial nerve regeneration.
Scientific reports
Zhang Q,Nguyen PD,Shi S,Burrell JC,Cullen DK,Le AD
Thu Apr 26 00:00:00 UTC 2018
Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.
Cell stem cell
Zhang M,Lin YH,Sun YJ,Zhu S,Zheng J,Liu K,Cao N,Li K,Huang Y,Ding S
100-18C was used in Cell Culture to provide an effective chemical approach for generating neural stem cells from mouse fibroblasts and reveals mechanistic insight into the underlying reprogramming process.
Thu May 05 00:00:00 UTC 2016
Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation.
Cell stem cell
Zhang M,Lin YH,Sun YJ,Zhu S,Zheng J,Liu K,Cao N,Li K,Huang Y,Ding S
100-18C was used in Cell Culture to provide an effective chemical approach for generating neural stem cells from mouse fibroblasts and reveals mechanistic insight into the underlying reprogramming process.
Thu May 05 00:00:00 UTC 2016
Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages.
Future science OA
Shu C,Smith SM,Little CB,Melrose J
Thu Dec 01 00:00:00 UTC 2016
Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
Proceedings of the National Academy of Sciences of the United States of America
Vincent T,Hermansson M,Bolton M,Wait R,Saklatvala J
Tue Jun 11 00:00:00 UTC 2002
