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Invitrogen
Human IL-12 p35 Recombinant Protein
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Product Details
RP-75615
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Amino acids Arg23- Ser219 containing an N-terminal His-tag
Tag
His-tag
Class
Recombinant
Type
Protein
Purity
>95%, by SDS-PAGE under reducing conditions
Conjugate
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Purification
purified
Storage buffer
20mM tris HCl, pH 8, with 50% glycerol, 1mM EDTA
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
This product contains purified recombinant human IL-12 p35 protein with an N-terminal hexahistidine tag.
This product may be used as a positive control in many immunological assays.
Target Information
Interleukin 12A is a novel signaling cytokine belonging to the Interleukin-6 protein superfamily. Interleukin-12 alpha chain precursor (IL-12A) is a 35-kD subunit of disulfide-linked heterodimer of cytokine IL-12 and has a broad array of biological activities. Reports suggest that IL-12A can act as a growth factor for activated T and NK cells and enhance the lytic activity of NK/lymphokine-activated Killer cells. IL-12A stimulates the production of IFN-gamma by resting PBMC as well as T-cell-independent induction of interferon (IFN)-gamma, and helps in the differentiation of both Th1 and Th2 cells. It is also involved in positive regulation of tyrosine phosphorylation of Stat4 protein. The signaling process of IL-12A in innate immunity requires nitric oxide synthase 2A. Along with EBI3, IL-12A forms a novel heterodimeric cytokine, designated as interleukin-35 (IL-35), that may be specifically produced by T reg cells and is required for maximal suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; il 12; IL-12 subunit p35; IL-12, subunit p35; IL-12A; IL12p35; IL35 subunit; ILN; Interleukin; Interleukin 12; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; Interleukin-12 subunit alpha; Interleukin12; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF1
Gene Aliases: CLMF; IL-12A; IL12A; NFSK; NKSF1; P35
UniProt ID: (Human) P29459
Entrez Gene ID: (Human) 3592
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