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Product Details
200-39-25UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Human
Expression System
E. coli
Amino acid sequence
MVHTSPKVKN LNPKKFSIHD QDHKVLVLDS GNLIAVPDKN YIRPEIFFAL ASSLSSASAE KGSPILLGVS KGEFCLYCDK DKGQSHPSLQ LKKEKLMKLA AQKESARRPF IFYRAQVGSW NMLESAAHPG WFICTSCNCN EPVGVTDKFE NRKHIEFSFQ PVCKAEMSPS EVSD
Molecular weight
19.4 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Measured by its ability to bind Interleukin-18 Binding Protein isoform a (IL-18 BPa) in functional ELISA.
Conjugate
Unconjugated
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FIL1 zeta; IL-1 zeta; IL-1F7; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1H; IL-1RP1; IL-1X; IL-1X protein; IL-37; IL1F7 (canonical product IL-1F7b); ILN; Interleukin; interleukin 1 family member 7; interleukin 1, zeta; Interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; Interleukin-1-related protein; interleukin-23; Interleukin-37; Interleukin37
Gene Aliases: FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H; IL-1H4; IL-1RP1; IL-37; IL1F7; IL1H4; IL1RP1; IL37
UniProt ID: (Human) Q9NZH6
Entrez Gene ID: (Human) 27178
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