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Invitrogen
Human KChIP3 (aa 38-88) Control Fragment Recombinant Protein
Product Details
RP-107716
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKF
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Voltage-gated potassium (Kv) channels are key components of the potassium currents in the heart and central nervous system. In the heart, Kv4 channels are involved in the repolarization phase of the action potential. In the brain however, these channels prevent reverse-propagation of action potentials. Found associated with Kv4 channels are a group of calcium-binding proteins termed KChIPs (Kv channel interacting proteins). KChIPs are small molecular weight proteins that bind to the cytoplasmic amino termini of Kv4 alpha-subunits and help to modulate its function. There are currently three known KChIPs; KChIP1 expressed in the brain; KChIP2 expressed in the brain, heart, and lung, and has three isoforms, a, b, and c; and KChIP3, also known as calsenilin and DREAM (downstream regulatory elements (DRE)-antagonist modulator) which is expressed in the brain and testis. KChIP3 has activities beyond the modulation of Kv4 currents. It has been shown that KChIP3 binds to the regulatory DRE and represses transcription from the early-response gene c-fos. Thus, KCHiP3 is the first known calcium-binding protein to function as a DNA-binding transcriptional regulator. KChIP3 is also found associated with the presenilins and is implicated in the mediation of beta-amyloid formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 3; Calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; DRE-antagonist modulator; DREAM; KChIP3; Kv channel interacting protein 3; Kv channel interacting protein 3, calsenilin; Kv channel-interacting protein 3; potassium channel interacting protein 3
Gene Aliases: CSEN; DREAM; KCHIP3; KCNIP3
UniProt ID: (Human) Q9Y2W7
Entrez Gene ID: (Human) 30818
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