Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 17 amino acid peptide near the carboxy terminus of human LRRFIP2.
PEP-1229 can be used as a blocking peptide with polyclonal antibody PA5-21115.
The leucine-rich repeat FLI-I-interacting protein 2 (LRRFIP2), like the related protein LRRFIP1, was identified in a yeast two-hybrid system through binding to the LRR domain of human FLI. It can activate the Wnt signaling pathway in cultured cells and is thought to be a component of the Wnt signaling pathway that modulates Wnt signaling through interactions with Disheveled to increase the cellular levels and transcription activity of beta-catenin. LRRFIP2 has recently been characterized as a positive regulator of the TLR4 signaling pathway for activating NF-kappa-B during the early host response to LPS stimulation through binding to the TLR adaptor protein MyD88, and that this interaction with MyD88 is governed by phosphorylation of specific residues in LRRFIP2.
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Protein Aliases: leucine rich repeat (in FLII) interacting protein 2; Leucine-rich repeat flightless-interacting protein 2; LRR FLII-interacting protein 2
Gene Aliases: HUFI-2; LRRFIP2
UniProt ID: (Human) Q9Y608
Entrez Gene ID: (Human) 9209
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