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Invitrogen
Human NCOA6 (aa 1912-2041) Control Fragment Recombinant Protein
Product Details
RP-106262
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
TSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (85%), Rat (85%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-65601. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activating signal cointegrator 2; activating signal cointegrator-2; Amplified in breast cancer protein 3; amplified in breast cancer-3 protein; ASC-2; Cancer-amplified transcriptional coactivator ASC-2; NRC RAP250; Nuclear receptor coactivator 6; Nuclear receptor coactivator RAP250; Nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor interacting protein; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; thyroid hormone receptor binding protein; Thyroid hormone receptor-binding protein
Gene Aliases: AIB3; ASC2; KIAA0181; NCOA6; NRC; PRIP; RAP250; TRBP
UniProt ID: (Human) Q14686
Entrez Gene ID: (Human) 23054
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