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This peptide corresponds to 19 amino acids near the amino terminus of human ORAI3.
PEP-0487 can be used as a blocking peptide with polyclonal antibody PA5-20370.
ORAI3 is a protein coding gene that is involved in calcium signaling and regulation of calcium homeostasis. It is a member of the ORAI family of proteins that form calcium release-activated calcium (CRAC) channels in the plasma membrane of cells. These channels are activated by depletion of calcium from the endoplasmic reticulum, leading to an influx of calcium ions into the cytoplasm. ORAI3 has been implicated in a variety of physiological processes, including T-cell activation, muscle contraction, and neurotransmitter release. Dysregulation of ORAI3 expression or function has been associated with various diseases, including immune disorders, cancer, and cardiovascular disease
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Protein Aliases: Protein orai-3; Transmembrane protein 142C
Gene Aliases: ORAI3; TMEM142C
UniProt ID: (Human) Q9BRQ5
Entrez Gene ID: (Human) 93129
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