Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
This peptide corresponds to 19 amino acids near the carboxy terminus of human PION.
PEP-1206 can be used as a blocking peptide with polyclonal antibody PA5-21092.
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta-amyloid protein precursor (APP) is cleaved by one of two beta-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for -gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients’ brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both -gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gamma-secretase-activating protein; GSAP; pigeon homolog; Protein pigeon homolog; tcag7.1314
Gene Aliases: GSAP; PION
UniProt ID: (Human) A4D1B5
Entrez Gene ID: (Human) 54103
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