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Gibco

Human Prokineticin-2 Recombinant Protein, PeproTech®

Name: Human Prokineticin-2 Recombinant Protein, PeproTech®
Brand: Gibco
SKU: 100-46-20UG
Price: 5736.75 MXN

8 References

View all (2) PROK2 proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

100-46-20UG

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 6 publications 6 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species

Human

Published species

Human, Mouse, Rat

Expression System

E. coli

Amino acid sequence

AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K

Molecular weight

8.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Conjugate

Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.

Scientific reports

Noda K,Dufner B,Ito H,Yoshida K,Balboni G,Straub RH

Wed Sep 15 00:00:00 UTC 2021

A Prokineticin-Driven Epigenetic Switch Regulates Human Epicardial Cell Stemness and Fate.

Stem cells (Dayton, Ohio)

Qureshi R,Kindo M,Boulberdaa M,von Hunolstein JJ,Steenman M,Nebigil CG

Mon Oct 01 00:00:00 UTC 2018

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

The Journal of biological chemistry

Xin H,Lu R,Lee H,Zhang W,Zhang C,Deng J,Liu Y,Shen S,Wagner KU,Forman S,Jove R,Yu H

Fri May 10 00:00:00 UTC 2013

G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.

The Journal of biological chemistry

Xin H,Lu R,Lee H,Zhang W,Zhang C,Deng J,Liu Y,Shen S,Wagner KU,Forman S,Jove R,Yu H

Fri May 10 00:00:00 UTC 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 UTC 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 UTC 2013

A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis.

PloS one

McDowell EN,Kisielewski AE,Pike JW,Franco HL,Yao HH,Johnson KJ

Tue May 07 00:00:00 UTC 2013

A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis.

PloS one

McDowell EN,Kisielewski AE,Pike JW,Franco HL,Yao HH,Johnson KJ

Tue May 07 00:00:00 UTC 2013

Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake.

Diabetes

Gardiner JV,Bataveljic A,Patel NA,Bewick GA,Roy D,Campbell D,Greenwood HC,Murphy KG,Hameed S,Jethwa PH,Ebling FJ,Vickers SP,Cheetham S,Ghatei MA,Bloom SR,Dhillo WS

Mon Feb 01 00:00:00 UTC 2010

Characterization and regulation of bv8 in human blood cells.

Clinical cancer research : an official journal of the American Association for Cancer Research

Zhong C,Qu X,Tan M,Meng YG,Ferrara N

Wed Apr 15 00:00:00 UTC 2009

G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models.

Proceedings of the National Academy of Sciences of the United States of America

Shojaei F,Wu X,Qu X,Kowanetz M,Yu L,Tan M,Meng YG,Ferrara N

Tue Apr 21 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: PK2; Prokineticin-2; Protein Bv8 homolog

Gene Aliases: BV8; HH4; KAL4; MIT1; PK2; PROK2

UniProt ID: (Human) Q9HC23

Entrez Gene ID: (Human) 60675

Human Prokineticin-2 Recombinant Protein, PeproTech®

Product Details

100-46-20UG

Functional Assay (Functional)

In vitro Assay (IV)

Miscellaneous PubMed (Misc)

Species

Published species

Expression System

Amino acid sequence

Molecular weight

Class

Type

Purity

Endotoxin concentration

Conjugate

Form

Purification

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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