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Invitrogen
Human RXRA, Ligand Binding Domain, GST Tag Recombinant Protein
Product Details
PV4799
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
204-462
Tag
GST-tag
Class
Recombinant
Type
Protein
Conjugate
Unconjugated
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
proprietary buffer
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
Retinoid X receptor alpha, ligand binding domain (RXRA-LBD) is a 56.67 kDa recombinant human protein (amino acids 204-462) expressed as a GST fusion protein in baculovirus-infected insect cells. RXRA-LBD was expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies.
Specifications:
Functional assay: Functionally confirmed in a LanthaScreen™ TR-FRET coactivator assay to ensure performance.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha
Gene Aliases: NR2B1; RXRA
UniProt ID: (Human) P19793
Entrez Gene ID: (Human) 6256
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