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Product Details
RP-88161
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
Human S100B, amino acids Ser2-Glu92 (Accession # NP_006263.1) with an N-terminal His-tag
Tag
His-tag
Molecular weight
12 kDa
Class
Recombinant
Type
Protein
Purity
>90% as determined by SDS-PAGE.
Activity
1. Measured by its ability to bind human AGER in a functional ELISA. 2. Measured by its ability to bind TP53 in a functional ELISA.
Conjugate
Form
Lyophilized
Concentration
0.25 mg/mL
Purification
purified
Storage buffer
PBS, pH 7.5, with 10% glycerol, 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (400 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100B may function in neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium binding protein beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); S100 protein beta chain
Gene Aliases: NEF; S100; S100-B; S100B; S100beta
UniProt ID: (Human) P04271
Entrez Gene ID: (Human) 6285
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