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Product Details
PV4056
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
60-431
Tag
GST-tag
Molecular weight
69.7 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 0.5mM EDTA, 150mM NaCl, 2mM DTT, 50% glycerol, 0.02% Triton X-100
Contains
no preservative
Storage conditions
-80° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Catalytic
Target Information
SGK (SGK1) is a serine/threonine kinase that may be a transcriptional target for p38/MAPK in hepatoma cells. SGK plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: serine/threonine protein kinase SGK; Serine/threonine-protein kinase Sgk1; Serum/glucocorticoid-regulated kinase 1; Sgk1 variant i3
Gene Aliases: SGK; SGK1
UniProt ID: (Human) O00141
Entrez Gene ID: (Human) 6446
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