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PEP-286 is a 17 amino acid synthetic peptide whose sequence is derived from human SNX1 protein. The sequence of this peptide is (amino to carboxy terminus): Q (139)-E-D-Q-F-D-L-T-V-G-I-T-D-P-E-K-I (155)
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product, SNX1, catalog # PA1-836. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions.
Reconstitute with 0.1 mL of distilled water.
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MGC8664; SNX1A; sorting nexin 1A; Sorting nexin-1
Gene Aliases: HsT17379; SNX1; VPS5
UniProt ID: (Human) Q13596
Entrez Gene ID: (Human) 6642
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