Product References
Modeling drug-induced liver injury and screening for anti-hepatofibrotic compounds using human PSC-derived organoids.
Cell regeneration (London, England)
Wu X,Jiang D,Yang Y,Li S,Ding Q
AF-100-21C was used in Tissue/organ culture to demonstrate the potential applications of human liver organoids in drug safety testing and anti-fibrotic drug screening.
Fri Mar 03 00:00:00 UTC 2023
Programmable RNA targeting with the single-protein CRISPR effector Cas7-11.
Nature
Özcan A,Krajeski R,Ioannidi E,Lee B,Gardner A,Makarova KS,Koonin EV,Abudayyeh OO,Gootenberg JS
Wed Sep 01 00:00:00 UTC 2021
Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells.
Immunity
Kawakami R,Kitagawa Y,Chen KY,Arai M,Ohara D,Nakamura Y,Yasuda K,Osaki M,Mikami N,Lareau CA,Watanabe H,Kondoh G,Hirota K,Ohkura N,Sakaguchi S
Tue May 11 00:00:00 UTC 2021
Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Monteiro DA,Dole NS,Campos JL,Kaya S,Schurman CA,Belair CD,Alliston T
Mon Mar 01 00:00:00 UTC 2021
Mechanosensitive miR-100 coordinates TGFβ and Wnt signaling in osteocytes during fluid shear stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dole NS,Yoon J,Monteiro DA,Yang J,Mazur CM,Kaya S,Belair CD,Alliston T
Fri Oct 01 00:00:00 UTC 2021
Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions.
The Journal of steroid biochemistry and molecular biology
Ma L,Andrieu T,McKinnon B,Duempelmann L,Peng RW,Wotzkow C,Müller C,Mueller MD
AF-100-21C was used in In vitro experiments to indicate that EMT contributes to the downregulation of PR expression via the upregulation of EMT-TFs, like SNAI1 and SNAI2, which may ultimately lead to progesterone resistance.
Wed Sep 01 00:00:00 UTC 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
AF-100-21C was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 UTC 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
AF-100-21C was used in Sample Preparation (FC/FACS) to report a chemically defined xeno-free culture system which can be used to culture and derive human extended pluripotent stem (EPS) cells in vitro.
Fri May 21 00:00:00 UTC 2021
Cell-assembled extracellular matrix (CAM) sheet production: Translation from using human to large animal cells.
Journal of tissue engineering
Torres Y,Gluais M,Da Silva N,Rey S,Grémare A,Magnan L,Kawecki F,L'Heureux N
AF-100-21C was used in Cell Culture to compare the tissue development and composition of cell-assembled extracellular matrix sheets between different sources of skin fibroblasts, including ovine and human fibroblasts, for use in production of tissue-engineered vascular grafts.
Thu May 02 00:00:00 UTC 2024
Cell-assembled extracellular matrix (CAM) sheet production: Translation from using human to large animal cells.
Journal of tissue engineering
Torres Y,Gluais M,Da Silva N,Rey S,Grémare A,Magnan L,Kawecki F,L'Heureux N
AF-100-21C was used in Cell Culture to compare the tissue development and composition of cell-assembled extracellular matrix sheets between different sources of skin fibroblasts, including ovine and human fibroblasts, for use in production of tissue-engineered vascular grafts.
Thu May 02 00:00:00 UTC 2024
Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.
Cell death & disease
Breuls N,Giarratana N,Yedigaryan L,Garrido GM,Carai P,Heymans S,Ranga A,Deroose C,Sampaolesi M
Mon Jul 05 00:00:00 UTC 2021
Germacrone Attenuates Hepatic Stellate Cells Activation and Liver Fibrosis via Regulating Multiple Signaling Pathways.
Frontiers in pharmacology
Li Z,Wang Z,Dong F,Shi W,Dai W,Zhao J,Li Q,Fang ZE,Ren L,Liu T,Wei Z,Mou W,Lin L,Yang Y,Xiao X,Ma L,Bai Z
AF-100-21C was used in Sample Preparation (Western Blotting) to demonstrate that germacrone (GER) can be used as a potential therapeutic drug for the treatment of liver fibrosis.
Sat Oct 23 00:00:00 UTC 2021
TGF-β1-mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis.
Cell death & disease
Wu D,Deng S,Li L,Liu T,Zhang T,Li J,Yu Y,Xu Y
Tue Jul 20 00:00:00 UTC 2021
Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.
Scientific reports
Sapra L,Dar HY,Bhardwaj A,Pandey A,Kumari S,Azam Z,Upmanyu V,Anwar A,Shukla P,Mishra PK,Saini C,Verma B,Srivastava RK
Tue Jan 19 00:00:00 UTC 2021
IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation.
Cell death & disease
Cui J,Xu H,Yu J,Li Y,Chen Z,Zou Y,Zhang X,Du Y,Xia J,Wu J
Tue May 18 00:00:00 UTC 2021
SMAD4 represses FOSL1 expression and pancreatic cancer metastatic colonization.
Cell reports
Dai C,Rennhack JP,Arnoff TE,Thaker M,Younger ST,Doench JG,Huang AY,Yang A,Aguirre AJ,Wang B,Mun E,O'Connell JT,Huang Y,Labella K,Talamas JA,Li J,Ilic N,Hwang J,Hong AL,Giacomelli AO,Gjoerup O,Root DE,Hahn WC
Tue Jul 27 00:00:00 UTC 2021
Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells.
Nature protocols
Vallverdú J,Martínez García de la Torre RA,Mannaerts I,Verhulst S,Smout A,Coll M,Ariño S,Rubio-Tomás T,Aguilar-Bravo B,Martínez-Sánchez C,Blaya D,Verfaillie CM,van Grunsven LA,Sancho-Bru P
AF-100-21C was used in In vitro experiments to describe a protocol to differentiate human induced pluripotent stem cells (iPSCs) into hepatic stellate cells (iPSC-HSCs).
Sat May 01 00:00:00 UTC 2021
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
Science translational medicine
Montiel V,Bella R,Michel LYM,Esfahani H,De Mulder D,Robinson EL,Deglasse JP,Tiburcy M,Chow PH,Jonas JC,Gilon P,Steinhorn B,Michel T,Beauloye C,Bertrand L,Farah C,Dei Zotti F,Debaix H,Bouzin C,Brusa D,Horman S,Vanoverschelde JL,Bergmann O,Gilis D,Rooman M,Ghigo A,Geninatti-Crich S,Yool A,Zimmermann WH,Roderick HL,Devuyst O,Balligand JL
AF-100-21C was used in Cell Culture to investigate regulators of oxidant-mediated cardiac hypertrophy.
Wed Oct 07 00:00:00 UTC 2020
Ginkgolic Acid, a SUMO-1 Inhibitor, Inhibits the Progression of Oral Squamous Cell Carcinoma by Alleviating SUMOylation of SMAD4.
Molecular therapy oncolytics
Liu K,Wang X,Li D,Xu D,Li D,Lv Z,Zhao D,Chu WF,Wang XF
AF-100-21C was used in Cell Culture to conclude that GA could be a promising therapeutic for OSCC.
Fri Mar 27 00:00:00 UTC 2020
Involvement of Transcription Factor 21 in the Pathogenesis of Fibrosis in Endometriosis.
The American journal of pathology
Ganieva U,Nakamura T,Osuka S,Nakanishi N,Kasahara Y,Takasaki N,Muraoka A,Hayashi S,Nagai T,Murase T,Goto M,Iwase A,Kikkawa F
AF-100-21C was used in In vitro experiments to study whether transcription factor 21 (TCF21) is involved in the development of endometriosis as an upstream regulatory gene of periostin.
Wed Jan 01 00:00:00 UTC 2020
Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis.
Scientific reports
Barbosa DM,Fahlbusch P,Herzfeld de Wiza D,Jacob S,Kettel U,Al-Hasani H,Krüger M,Ouwens DM,Hartwig S,Lehr S,Kotzka J,Knebel B
Tue Mar 17 00:00:00 UTC 2020
Curcumin attenuates endothelial cell fibrosis through inhibiting endothelial-interstitial transformation.
Clinical and experimental pharmacology & physiology
Chen X,Chen X,Shi X,Gao Z,Guo Z
AF-100-21C was used in In vitro experiments to demonstrate that Cur inhibits TGF-β1-induced endothelial-to-mesenchymal transition (EndMT) by stimulating DDAH1 expression via the NRF-2 pathway, thus attenuating endothelial cell fibrosis.
Wed Jul 01 00:00:00 UTC 2020
Epithelial-mesenchymal transition gene signature is associated with prognosis and tumor microenvironment in head and neck squamous cell carcinoma.
Scientific reports
Jung AR,Jung CH,Noh JK,Lee YC,Eun YG
Thu Feb 27 00:00:00 UTC 2020
A FXYD5/TGF‑β/SMAD positive feedback loop drives epithelial‑to‑mesenchymal transition and promotes tumor growth and metastasis in ovarian cancer.
International journal of oncology
Bai Y,Li LD,Li J,Chen RF,Yu HL,Sun HF,Wang JY,Lu X
AF-100-21C was used in In vitro experiments to suggest a mechanism through which FXYD5 serves a critical role in the constitutive activation of the TGF-β/SMADs signaling pathways in ovarian cancer, and provided a promising therapeutic target for human ovarian cancer.
Wed Jan 01 00:00:00 UTC 2020
TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts.
Nature communications
Grauel AL,Nguyen B,Ruddy D,Laszewski T,Schwartz S,Chang J,Chen J,Piquet M,Pelletier M,Yan Z,Kirkpatrick ND,Wu J,deWeck A,Riester M,Hims M,Geyer FC,Wagner J,MacIsaac K,Deeds J,Diwanji R,Jayaraman P,Yu Y,Simmons Q,Weng S,Raza A,Minie B,Dostalek M,Chikkegowda P,Ruda V,Iartchouk O,Chen N,Thierry R,Zhou J,Pruteanu-Malinici I,Fabre C,Engelman JA,Dranoff G,Cremasco V
Wed Dec 09 00:00:00 UTC 2020
On-chip integrated optical stretching and electrorotation enabling single-cell biophysical analysis.
Microsystems & nanoengineering
Huang L,Liang F,Feng Y,Zhao P,Wang W
Wed Sep 29 00:00:00 UTC 2021
PCDHGA9 represses epithelial-mesenchymal transition and metastatic potential in gastric cancer cells by reducing β-catenin transcriptional activity.
Cell death & disease
Weng J,Li S,Lin H,Mei H,Liu Y,Xiao C,Zhu Z,Cai W,Ding X,Mi Y,Wen Y
Mon Mar 30 00:00:00 UTC 2020
Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses.
Cell death & disease
Hutchinson LD,Darling NJ,Nicolaou S,Gori I,Squair DR,Cohen P,Hill CS,Sapkota GP
Wed Jan 22 00:00:00 UTC 2020
Generation of Engineered Human Myocardium in a Multi-well Format.
STAR protocols
Tiburcy M,Meyer T,Liaw NY,Zimmermann WH
Fri Jun 19 00:00:00 UTC 2020
MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer.
Oncogene
He W,Liang B,Wang C,Li S,Zhao Y,Huang Q,Liu Z,Yao Z,Wu Q,Liao W,Zhang S,Liu Y,Xiang Y,Liu J,Shi M
Sat Jun 01 00:00:00 UTC 2019
HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer.
Oncogenesis
Yang H,Liang SQ,Xu D,Yang Z,Marti TM,Gao Y,Kocher GJ,Zhao H,Schmid RA,Peng RW
Tue Aug 20 00:00:00 UTC 2019
TGF-β1-PML SUMOylation-peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) form a positive feedback loop to regulate cardiac fibrosis.
Journal of cellular physiology
Wu D,Huang D,Li LL,Ni P,Li XX,Wang B,Han YN,Shao XQ,Zhao D,Chu WF,Li BY
AF-100-21C was used in In vitro experiments to find that exogenous TGF-β1 induced the upregulation of TGF-β1 itself in a time- and dose-dependent manner, and also triggered the PML SUMOylation and the formation of PML nuclear bodies (PML-NBs), and consequently recruited Pin1 into nuclear to colocalize with PML.
Wed May 01 00:00:00 UTC 2019
Smooth muscle cell-specific knockout of neuropilin-1 impairs postnatal lung development and pathological vascular smooth muscle cell accumulation.
American journal of physiology. Cell physiology
Mahmoud M,Evans IM,Mehta V,Pellet-Many C,Paliashvili K,Zachary I
Fri Mar 01 00:00:00 UTC 2019
Myofibroblast modulation of cardiac myocyte structure and function.
Scientific reports
Nagaraju CK,Dries E,Gilbert G,Abdesselem M,Wang N,Amoni M,Driesen RB,Sipido KR
Thu Jun 20 00:00:00 UTC 2019
Vascular endothelial growth factor 165 inhibits pro-fibrotic differentiation of stromal cells via the DLL4/Notch4/smad7 pathway.
Cell death & disease
Lv H,Nan Z,Jiang P,Wang Z,Song M,Ding H,Liu D,Zhao G,Zheng Y,Hu Y
Thu Sep 12 00:00:00 UTC 2019
Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture.
Scientific reports
Shichi Y,Sasaki N,Michishita M,Hasegawa F,Matsuda Y,Arai T,Gomi F,Aida J,Takubo K,Toyoda M,Yoshimura H,Takahashi K,Ishiwata T
Fri Jul 26 00:00:00 UTC 2019
Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture.
Scientific reports
Shichi Y,Sasaki N,Michishita M,Hasegawa F,Matsuda Y,Arai T,Gomi F,Aida J,Takubo K,Toyoda M,Yoshimura H,Takahashi K,Ishiwata T
Fri Jul 26 00:00:00 UTC 2019
Human cell-derived tissue-engineered heart valve with integrated Valsalva sinuses: towards native-like transcatheter pulmonary valve replacements.
NPJ Regenerative medicine
Motta SE,Lintas V,Fioretta ES,Dijkman PE,Putti M,Caliskan E,Rodriguez Cetina Biefer H,Lipiski M,Sauer M,Cesarovic N,Hoerstrup SP,Emmert MY
Thu Oct 01 00:00:00 UTC 2020
Dioscin Inhibits the Invasion and Migration of Hepatocellular Carcinoma HepG2 Cells by Reversing TGF-β1-Induced Epithelial-Mesenchymal Transition.
Molecules (Basel, Switzerland)
Chen B,Zhou S,Zhan Y,Ke J,Wang K,Liang Q,Hou Y,Zhu P,Ao W,Wei X,Xiao J
AF-100-21C was used in Sample Preparation (WB) to investigate anticancer effects of Dioscin.
Fri Jun 14 00:00:00 UTC 2019
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.
Journal of cellular and molecular medicine
Wu J,Xing C,Zhang L,Mao H,Chen X,Liang M,Wang F,Ren H,Cui H,Jiang A,Wang Z,Zou M,Ji Y
AF-100-21C was used in In vitro experiments to investigate elevation of TGF-β1 in the peritoneal membrane following peritoneal dialysis.
Thu Feb 01 00:00:00 UTC 2018
Lung resident mesenchymal cells isolated from patients with the Bronchiolitis Obliterans Syndrome display a deregulated epigenetic profile.
Scientific reports
Vella S,Conaldi PG,Cova E,Meloni F,Liotta R,Cuzzocrea S,Martino L,Bertani A,Luca A,Vitulo P
Tue Jul 24 00:00:00 UTC 2018
An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis.
Scientific reports
Yamashita T,Lakota K,Taniguchi T,Yoshizaki A,Sato S,Hong W,Zhou X,Sodin-Semrl S,Fang F,Asano Y,Varga J
Tue Aug 07 00:00:00 UTC 2018
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis.
Cell stem cell
Coll M,Perea L,Boon R,Leite SB,Vallverdú J,Mannaerts I,Smout A,El Taghdouini A,Blaya D,Rodrigo-Torres D,Graupera I,Aguilar-Bravo B,Chesne C,Najimi M,Sokal E,Lozano JJ,van Grunsven LA,Verfaillie CM,Sancho-Bru P
AF-100-21C was used in In vitro experiments to report efficient differentiation of human pluripotent stem cells into HSC-like cells (iPSC-HSCs).
Thu Jul 05 00:00:00 UTC 2018
HLTF suppresses the migration and invasion of colorectal cancer cells via TGF‑β/SMAD signaling in vitro.
International journal of oncology
Liu L,Liu H,Zhou Y,He J,Liu Q,Wang J,Zeng M,Yuan D,Tan F,Zhou Y,Pei H,Zhu H
AF-100-21C was used in Cell Culture to suggest that HLTF is negatively associated with the progression of CRC, and its overexpression suppresses the migration and invasion of CRC cells by targeting the TGF-β/SMAD pathway.
Sat Dec 01 00:00:00 UTC 2018
Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery.
Stem cells translational medicine
Frisch J,Orth P,Venkatesan JK,Rey-Rico A,Schmitt G,Kohn D,Madry H,Cucchiarini M
Sun Jan 01 00:00:00 UTC 2017
Development of a Three-Dimensional Bioengineering Technology to Generate Lung Tissue for Personalized Disease Modeling.
Stem cells translational medicine
Wilkinson DC,Alva-Ornelas JA,Sucre JM,Vijayaraj P,Durra A,Richardson W,Jonas SJ,Paul MK,Karumbayaram S,Dunn B,Gomperts BN
Wed Feb 01 00:00:00 UTC 2017
Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3.
Scientific reports
He H,Kuriyan AE,Su CW,Mahabole M,Zhang Y,Zhu YT,Flynn HW,Parel JM,Tseng SC
AF-100-21C was used in In vitro experiments to investigate heavy chain-hyaluronic acid/pentraxin 3 inhibition of proliferative vitreoretinopathy.
Thu Mar 02 00:00:00 UTC 2017
Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease.
Frontiers in neuroscience
Naphade S,Embusch A,Madushani KL,Ring KL,Ellerby LM
AF-100-21C was used in Sample Preparation to investigate matrix metalloproteases in Huntington’s Disease.
Wed Sep 30 00:00:00 UTC 2020
The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration.
Scientific reports
Wu X,Liu W,Duan Z,Gao Y,Li S,Wang K,Song Y,Shao Z,Yang S,Yang C
Wed Jul 27 00:00:00 UTC 2016
