Product References
Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma.
Journal of experimental & clinical cancer research : CR
Zhang B,Ohuchida K,Tsutsumi C,Shimada Y,Mochida Y,Oyama K,Iwamoto C,Sheng N,Fei S,Shindo K,Ikenaga N,Nakata K,Oda Y,Nakamura M
250-31L was used in Tissue/organ culture to demonstrate the impact of dynamic glycolytic reprogramming on the composition of immune cells in the tumor microenvironment of pancreatic ductal adenocarcinoma, especially on the antigen-presenting function of dendritic cells.
Mon Sep 30 00:00:00 UTC 2024
Eosinophils protect against pulmonary hypertension through 14-HDHA and 17-HDHA.
The European respiratory journal
Shu T,Zhang J,Zhou Y,Chen Z,Li J,Tang Q,Lei W,Xing Y,Wang J,Wang C
250-31L was used in Cell Culture to show that in PH development without external inflammatory stimulus, peripheral blood exhibits a low EOS level, in which EOS play a protective role through suppressing perivascular inflammation and maintaining PASMC homeostasis via 14/17-HDHA.
Wed Mar 01 00:00:00 UTC 2023
Active eosinophils regulate host defence and immune responses in colitis.
Nature
Gurtner A,Borrelli C,Gonzalez-Perez I,Bach K,Acar IE,Núñez NG,Crepaz D,Handler K,Vu VP,Lafzi A,Stirm K,Raju D,Gschwend J,Basler K,Schneider C,Slack E,Valenta T,Becher B,Krebs P,Moor AE,Arnold IC
250-31L was used in Cell Culture to provide insights into the biology of eosinophils and highlight the crucial contribution of this cell type to intestinal homeostasis, immune regulation and host defence.
Wed Mar 01 00:00:00 UTC 2023
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Cell stem cell
Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X
250-31L was used in In vitro experiments to show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.
Thu Jan 05 00:00:00 UTC 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
250-31L was used in In vitro experiments to establish both direct and indirect roles for ILC2 in peri-aortic CaPO4 injury-induced mouse abdominal aortic aneurysms.
Wed Mar 01 00:00:00 UTC 2023
Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Cancer discovery
Togami K,Chung SS,Madan V,Booth CAG,Kenyon CM,Cabal-Hierro L,Taylor J,Kim SS,Griffin GK,Ghandi M,Li J,Li YY,Angelot-Delettre F,Biichle S,Seiler M,Buonamici S,Lovitch SB,Louissaint A,Morgan EA,Jardin F,Piccaluga PP,Weinstock DM,Hammerman PS,Yang H,Konopleva M,Pemmaraju N,Garnache-Ottou F,Abdel-Wahab O,Koeffler HP,Lane AA
250-31L was used in Cell Culture to investigate sex differences in blastic plasmacytoid dendritic cell neoplasm.
Tue Feb 01 00:00:00 UTC 2022
Transition from cMyc to L-Myc during dendritic cell development coordinated by rising levels of IRF8.
The Journal of experimental medicine
Anderson DA,Ou F,Kim S,Murphy TL,Murphy KM
Mon Feb 07 00:00:00 UTC 2022
PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
The Journal of experimental medicine
Liu M,Wu C,Luo S,Hua Q,Chen HT,Weng Y,Xu J,Lin H,Wang L,Li J,Zhu L,Guo Z,Zhuang SM,Kang T,Zheng L
250-31L was used in Sample Preparation (FC/FACS) to indicate that PERK-mediated HSPC preconditioning plays a crucial role in MDSC generation, suggesting novel spleen-targeting therapeutic opportunities for restraining the tumor-promoting myeloid response at its source.
Mon Apr 04 00:00:00 UTC 2022
Methionine- and Choline-Deficient Diet Identifies an Essential Role for DNA Methylation in Plasmacytoid Dendritic Cell Biology.
Journal of immunology (Baltimore, Md. : 1950)
Singh Rawat B,Venkataraman R,Budhwar R,Tailor P
Tue Feb 15 00:00:00 UTC 2022
Siglec-F Promotes IL-33-Induced Cytokine Release from Bone Marrow-Derived Eosinophils Independently of the ITIM and ITIM-like Motif Phosphorylation.
Journal of immunology (Baltimore, Md. : 1950)
Westermann S,Dietschmann A,Doehler D,Castiglione K,Bochner BS,Voehringer D,Radtke D
Tue Feb 01 00:00:00 UTC 2022
OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
Frontiers in immunology
Xu L,Tian D,Zhou M,Ma J,Sun G,Jin H,Li M,Zhang D,Wu J
250-31L was used in Cell Culture to show that Ox40 deficiency dampened the Traf2/6-related NF-κB signaling pathway in eosinophils.
Tue Jun 21 00:00:00 UTC 2022
A culture platform to study quiescent hematopoietic stem cells following genome editing.
Cell reports methods
Shiroshita K,Kobayashi H,Watanuki S,Karigane D,Sorimachi Y,Fujita S,Tamaki S,Haraguchi M,Itokawa N,Aoyoama K,Koide S,Masamoto Y,Kobayashi K,Nakamura-Ishizu A,Kurokawa M,Iwama A,Okamoto S,Kataoka K,Takubo K
250-31L was used in Cell Culture to analyze HSC cell cycle quiescence by combining culture conditions that maintain quiescence with a CRISPR-Cas9 genome editing system optimized for HSCs.
Mon Dec 19 00:00:00 UTC 2022
Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer-Autonomous DNA-Sensing Signaling Axis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Xiong W,He W,Wang T,He S,Xu F,Wang Z,Wang X,Guo H,Ling J,Zhang H,Liu Y,Xing K,Li M,Zhang H,Li J,Niu N,Xue J,Zhan Q,Liu ZX,Bei JX,Huang P,Liu J,Xia L,Xia X
Tue Mar 01 00:00:00 UTC 2022
Txnip Enhances Fitness of Dnmt3a-Mutant Hematopoietic Stem Cells via p21.
Blood cancer discovery
Zhang CR,Ostrander EL,Kukhar O,Mallaney C,Sun J,Haussler E,Celik H,Koh WK,King KY,Gontarz P,Challen GA
250-31L was used in Cell Culture to identify a previously undescribed mechanism to explain increased fitness of DNMT3A-mutant clones under hematopoietic stress.
Thu May 05 00:00:00 UTC 2022
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.
Cell
Lu SX,De Neef E,Thomas JD,Sabio E,Rousseau B,Gigoux M,Knorr DA,Greenbaum B,Elhanati Y,Hogg SJ,Chow A,Ghosh A,Xie A,Zamarin D,Cui D,Erickson C,Singer M,Cho H,Wang E,Lu B,Durham BH,Shah H,Chowell D,Gabel AM,Shen Y,Liu J,Jin J,Rhodes MC,Taylor RE,Molina H,Wolchok JD,Merghoub T,Diaz LA,Abdel-Wahab O,Bradley RK
250-31L was used in Cell Culture to investigate RNA splicing effects in antigen production in cancer.
Thu Jul 22 00:00:00 UTC 2021
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells.
Cell research
Liu C,Gong Y,Zhang H,Yang H,Zeng Y,Bian Z,Xin Q,Bai Z,Zhang M,He J,Yan J,Zhou J,Li Z,Ni Y,Wen A,Lan Y,Hu H,Liu B
Fri Oct 01 00:00:00 UTC 2021
Mutations in the transcription factor FOXO1 mimic positive selection signals to promote germinal center B cell expansion and lymphomagenesis.
Immunity
Roberto MP,Varano G,Vinas-Castells R,Holmes AB,Kumar R,Pasqualucci L,Farinha P,Scott DW,Dominguez-Sola D
Tue Aug 10 00:00:00 UTC 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
250-31L was used in In vitro experiments to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 UTC 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
250-31L was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.
Mon Feb 15 00:00:00 UTC 2021
Multiorgan failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes.
The Journal of clinical investigation
Nagamachi A,Kanai A,Nakamura M,Okuda H,Yokoyama A,Shinriki S,Matsui H,Inaba T
250-31L was used in Cell Culture to conclude that Samd9/9L is a downstream regulator of IFN that controls receptor metabolism, with constitutive activation leading to multiorgan dysfunction.
Mon Feb 15 00:00:00 UTC 2021
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.
The Journal of experimental medicine
Rappe JCF,Finsterbusch K,Crotta S,Mack M,Priestnall SL,Wack A
Mon Nov 01 00:00:00 UTC 2021
A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.
The Journal of experimental medicine
Rappe JCF,Finsterbusch K,Crotta S,Mack M,Priestnall SL,Wack A
Mon Nov 01 00:00:00 UTC 2021
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Mon Jul 05 00:00:00 UTC 2021
The histone demethylase Lsd1 regulates multiple repressive gene programs during T cell development.
The Journal of experimental medicine
Stamos DB,Clubb LM,Mitra A,Chopp LB,Nie J,Ding Y,Das A,Venkataganesh H,Lee J,El-Khoury D,Li L,Bhandoola A,Bosselut R,Love PE
Mon Dec 06 00:00:00 UTC 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 UTC 2021
Pediatric MDS and bone marrow failure-associated germline mutations in SAMD9 and SAMD9L impair multiple pathways in primary hematopoietic cells.
Leukemia
Thomas ME,Abdelhamed S,Hiltenbrand R,Schwartz JR,Sakurada SM,Walsh M,Song G,Ma J,Pruett-Miller SM,Klco JM
Mon Nov 01 00:00:00 UTC 2021
The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity.
Cell death and differentiation
Novoszel P,Drobits B,Holcmann M,Fernandes CS,Tschismarov R,Derdak S,Decker T,Wagner EF,Sibilia M
Sun Aug 01 00:00:00 UTC 2021
Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis.
Cancer immunology research
Wang L,Yu S,Chan ER,Chen KY,Liu C,Che D,Awadallah A,Myers J,Askew D,Huang AY,Maillard I,Huang D,Xin W,Zhou L
250-31L was used in Cell Culture to study the significance of Notch-regulated dendritic cell (DC) immune responses in a mouse model of colitis-associated colorectal cancer in which there is epithelial downregulation of Notch/Hes1 signaling.
Mon Mar 01 00:00:00 UTC 2021
Brg1 restrains the pro-inflammatory properties of ILC3s and modulates intestinal immunity.
Mucosal immunology
Qi X,Qiu J,Chang J,Ji Y,Yang Q,Cui G,Sun L,Chai Q,Qin J,Qiu J
Fri Jan 01 00:00:00 UTC 2021
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis.
Blood advances
Gerosa RC,Boettcher S,Kovtonyuk LV,Hausmann A,Hardt WD,Hidalgo J,Nombela-Arrieta C,Manz MG
Tue Dec 14 00:00:00 UTC 2021
Nanocages displaying SIRP gamma clusters combined with prophagocytic stimulus of phagocytes potentiate anti-tumor immunity.
Cancer gene therapy
Choi Y,Nam GH,Kim GB,Kim S,Kim YK,Kim SA,Kim HJ,Lee EJ,Kim IS
Wed Sep 01 00:00:00 UTC 2021
B Lymphocyte Specification Is Preceded by Extensive Epigenetic Priming in Multipotent Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Strid T,Okuyama K,Tingvall-Gustafsson J,Kuruvilla J,Jensen CT,Lang S,Prasad M,Somasundaram R,Åhsberg J,Cristobal S,Soneji S,Ungerbäck J,Sigvardsson M
Tue Jun 01 00:00:00 UTC 2021
Acidic Calcium-Independent Phospholipase A2 Regulates Eosinophil-Mediated Pathology during Filarial Manifestation of Tropical Pulmonary Eosinophilia.
Journal of immunology (Baltimore, Md. : 1950)
Sharma P,Sharma A,Ganga L,Satoeya N,Jha R,Srivastava M
Mon Feb 15 00:00:00 UTC 2021
An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells.
STAR protocols
Haque M,Xiong X,Lei F,Das JK,Song J
250-31L was used in Cell Culture to describe the generation of hepatitis B virus (HBV) Ag-specific CTLs from induced pluripotent stem cells (iPSCs), i.e., iPSC-CTLs.
Fri Mar 19 00:00:00 UTC 2021
NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm-/- and old mice HSCs.
NPJ aging and mechanisms of disease
Zong L,Tanaka-Yano M,Park B,Yanai H,Turhan FT,Croteau DL,Tian J,Fang EF,Bohr VA,Beerman I
Tue Sep 21 00:00:00 UTC 2021
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.
Cell reports
Kim SP,Srivatsan SN,Chavez M,Shirai CL,White BS,Ahmed T,Alberti MO,Shao J,Nunley R,White LS,Bednarski J,Pehrson JR,Walter MJ
Tue Aug 31 00:00:00 UTC 2021
Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells.
Cell death & disease
Kurschat C,Metz A,Kirschnek S,Häcker G
Wed Aug 11 00:00:00 UTC 2021
Pharmacological inhibitors of anaplastic lymphoma kinase (ALK) induce immunogenic cell death through on-target effects.
Cell death & disease
Petrazzuolo A,Perez-Lanzon M,Martins I,Liu P,Kepp O,Minard-Colin V,Maiuri MC,Kroemer G
Fri Jul 16 00:00:00 UTC 2021
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection.
eLife
Liu X,Yu J,Xu L,Umphred-Wilson K,Peng F,Ding Y,Barton BM,Lv X,Zhao MY,Sun S,Hong Y,Qi L,Adoro S,Chen X
250-31L was used in Cell Culture to investigate Notch signaling in ER-associated degradation for proteome integrity in αβ T cells.
Fri Jul 09 00:00:00 UTC 2021
Lymph node-resident dendritic cells drive TH2 cell development involving MARCH1.
Science immunology
Castellanos CA,Ren X,Gonzalez SL,Li HK,Schroeder AW,Liang HE,Laidlaw BJ,Hu D,Mak ACY,Eng C,Rodríguez-Santana JR,LeNoir M,Yan Q,Celedón JC,Burchard EG,Zamvil SS,Ishido S,Locksley RM,Cyster JG,Huang X,Shin JS
250-31L was used in Cell Culture to suggest that TH2 cell development depends on ubiquitin-mediated clearance of antigen-presenting and costimulatory molecules by LN-resident DCs and consequent control of TCR signaling.
Fri Oct 15 00:00:00 UTC 2021
Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.
STAR protocols
Liang G,Huang B,Wang F,Liu F
250-31L was used in Flow cytometry/Cell sorting to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.
Fri Dec 17 00:00:00 UTC 2021
Syngeneic leukemia models using lentiviral transgenics.
Cell death & disease
Keinan N,Scharff Y,Goldstein O,Chamo M,Ilic S,Gazit R
Thu Feb 18 00:00:00 UTC 2021
Exposure to the Gram-Negative Bacteria Pseudomonas aeruginosa Influences the Lung Dendritic Cell Population Signature by Interfering With CD103 Expression.
Frontiers in cellular and infection microbiology
Brassard J,Roy J,Lemay AM,Beaulieu MJ,Bernatchez E,Veillette M,Duchaine C,Blanchet MR
250-31L was used in Cell Culture to verify whether the capacity of cDCs to express CD103 following P. aeruginosa exposure impacts the immune response.
Tue Jul 27 00:00:00 UTC 2021
TIFAB accelerates MLL-AF9-Induced acute myeloid leukemia through upregulation of HOXA9.
iScience
Zhao J,Xiu Y,Fu L,Dong Q,Borcherding N,Wang Y,Li Q,De Silva NS,Klein U,Boyce BF,Zhao C
250-31L was used in Cell Culture to investigate NF-kB deletion effects on MLL-AF9-AML.
Fri Dec 17 00:00:00 UTC 2021
TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
Nature communications
Yabe R,Chung SH,Murayama MA,Kubo S,Shimizu K,Akahori Y,Maruhashi T,Seno A,Kaifu T,Saijo S,Iwakura Y
Mon Jan 04 00:00:00 UTC 2021
Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner.
Cell reports
Ehrens A,Lenz B,Neumann AL,Giarrizzo S,Reichwald JJ,Frohberger SJ,Stamminger W,Buerfent BC,Fercoq F,Martin C,Kulke D,Hoerauf A,Hübner MP
Tue Jan 12 00:00:00 UTC 2021
MMP2 and TLRs modulate immune responses in the tumor microenvironment.
JCI insight
Muniz-Bongers LR,McClain CB,Saxena M,Bongers G,Merad M,Bhardwaj N
250-31L was used in Cell Culture to study the role of matrix metalloproteinase 2 (MMP2) in melanoma tumorigenesis.
Tue Jun 22 00:00:00 UTC 2021
Impact of Gold Nanoparticles on the Functions of Macrophages and Dendritic Cells.
Cells
Dey AK,Gonon A,Pécheur EI,Pezet M,Villiers C,Marche PN
250-31L was used in Cell Culture to investigate gold nanoparticle effect on the immune system.
Thu Jan 07 00:00:00 UTC 2021
Modulation of APLNR Signaling Is Required during the Development and Maintenance of the Hematopoietic System.
Stem cell reports
Jackson M,Fidanza A,Taylor AH,Rybtsov S,Axton R,Kydonaki M,Meek S,Burdon T,Medvinsky A,Forrester LM
Tue Apr 13 00:00:00 UTC 2021
Virus-based vaccine vectors with distinct replication mechanisms differentially infect and activate dendritic cells.
NPJ vaccines
Chiale C,Marchese AM,Furuya Y,Robek MD
Mon Nov 22 00:00:00 UTC 2021
The Metabolic Landscape of Thymic T Cell Development In Vivo and In Vitro.
Frontiers in immunology
Sun V,Sharpley M,Kaczor-Urbanowicz KE,Chang P,Montel-Hagen A,Lopez S,Zampieri A,Zhu Y,de Barros SC,Parekh C,Casero D,Banerjee U,Crooks GM
250-31L was used in Tissue/organ culture to suggest that highly conserved metabolic transitions are critical for thymic T cell development.
Mon Dec 20 00:00:00 UTC 2021
Tunable, division-independent control of gene activation timing by a polycomb switch.
Cell reports
Pease NA,Nguyen PHB,Woodworth MA,Ng KKH,Irwin B,Vaughan JC,Kueh HY
Tue Mar 23 00:00:00 UTC 2021
Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses.
Cell research
Hou S,Li Z,Zheng X,Gao Y,Dong J,Ni Y,Wang X,Li Y,Ding X,Chang Z,Li S,Hu Y,Fan X,Hou Y,Wen L,Liu B,Tang F,Lan Y
Fri May 01 00:00:00 UTC 2020
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Immunity
Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H
Tue Jul 14 00:00:00 UTC 2020
Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells.
Immunity
Lefkopoulos S,Polyzou A,Derecka M,Bergo V,Clapes T,Cauchy P,Jerez-Longres C,Onishi-Seebacher M,Yin N,Martagon-Calderón NA,Potts KS,Klaeylé L,Liu F,Bowman TV,Jenuwein T,Mione MC,Trompouki E
Tue Nov 17 00:00:00 UTC 2020
Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia.
Cancer cell
Witkowski MT,Dolgalev I,Evensen NA,Ma C,Chambers T,Roberts KG,Sreeram S,Dai Y,Tikhonova AN,Lasry A,Qu C,Pei D,Cheng C,Robbins GA,Pierro J,Selvaraj S,Mezzano V,Daves M,Lupo PJ,Scheurer ME,Loomis CA,Mullighan CG,Chen W,Rabin KR,Tsirigos A,Carroll WL,Aifantis I
Mon Jun 08 00:00:00 UTC 2020
MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells.
Blood
Gu H,Chen C,Hao X,Su N,Huang D,Zou Y,Lin SH,Chen X,Zheng D,Liu L,Yu Z,Xie L,Zhang Y,He X,Lai X,Zhang X,Chen GQ,Zhao Y,Yang Y,Loscalzo J,Zheng J
Thu Jul 30 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
250-31L was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 UTC 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
250-31L was used in Cell Culture to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 UTC 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Mon Mar 02 00:00:00 UTC 2020
The human fetal thymus generates invariant effector γδ T cells.
The Journal of experimental medicine
Tieppo P,Papadopoulou M,Gatti D,McGovern N,Chan JKY,Gosselin F,Goetgeluk G,Weening K,Ma L,Dauby N,Cogan A,Donner C,Ginhoux F,Vandekerckhove B,Vermijlen D
Mon Mar 02 00:00:00 UTC 2020
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
The Journal of experimental medicine
Arnold IC,Artola-Boran M,Gurtner A,Bertram K,Bauer M,Frangez Z,Becher B,Kopf M,Yousefi S,Simon HU,Tzankov A,Müller A
Mon Dec 07 00:00:00 UTC 2020
Fibroblast-Derived IL33 Facilitates Breast Cancer Metastasis by Modifying the Immune Microenvironment and Driving Type 2 Immunity.
Cancer research
Shani O,Vorobyov T,Monteran L,Lavie D,Cohen N,Raz Y,Tsarfaty G,Avivi C,Barshack I,Erez N
250-31L was used in In vitro experiments to show a novel interaction axis between CAF and immune cells and reveals the central role of CAF in establishing a hospitable inflammatory niche in lung metastasis.
Tue Dec 01 00:00:00 UTC 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
Mon Oct 05 00:00:00 UTC 2020
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S
Wed Jan 15 00:00:00 UTC 2020
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation.
Journal of immunology (Baltimore, Md. : 1950)
Coden ME,Loffredo LF,Walker MT,Jeong BM,Nam K,Bochner BS,Abdala-Valencia H,Berdnikovs S
Wed Jan 15 00:00:00 UTC 2020
Rapid Death of Follicular B Cells and Burkitt Lymphoma Cells Effectuated by Xbp1s.
Journal of immunology (Baltimore, Md. : 1950)
Chen YT,Kung JT
Mon Jun 15 00:00:00 UTC 2020
The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin.
Journal of immunology (Baltimore, Md. : 1950)
Vijayan A,Van Maele L,Fougeron D,Cayet D,Sirard JC
Sun Nov 15 00:00:00 UTC 2020
Targeting Antigens to Different Receptors on Conventional Type 1 Dendritic Cells Impacts the Immune Response.
Journal of immunology (Baltimore, Md. : 1950)
Fossum E,Tesfaye DY,Bobic S,Gudjonsson A,Braathen R,Lahoud MH,Caminschi I,Bogen B
Sat Aug 01 00:00:00 UTC 2020
Deletion of Nemo-like Kinase in T Cells Reduces Single-Positive CD8+ Thymocyte Population.
Journal of immunology (Baltimore, Md. : 1950)
Daams R,Sime W,Leandersson K,Sitnicka E,Massoumi R
Thu Oct 01 00:00:00 UTC 2020
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Gene therapy
Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G
Tue Sep 01 00:00:00 UTC 2020
Eosinophils improve cardiac function after myocardial infarction.
Nature communications
Liu J,Yang C,Liu T,Deng Z,Fang W,Zhang X,Li J,Huang Q,Liu C,Wang Y,Yang D,Sukhova GK,Lindholt JS,Diederichsen A,Rasmussen LM,Li D,Newton G,Luscinskas FW,Liu L,Libby P,Wang J,Guo J,Shi GP
Wed Dec 16 00:00:00 UTC 2020
Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells.
Scientific reports
Olender L,Bujanover N,Sharabi O,Goldstein O,Gazit R
Tue Feb 04 00:00:00 UTC 2020
A Comprehensive Experimental Guide to Studying Cross-Presentation in Dendritic Cells In Vitro.
Current protocols in immunology
Sadiq BA,Mantel I,Blander JM
250-31L was used in Cell Culture to describe methods to assess cross-presentation by DCs using the activation of primary CD8+ T cells as a readout.
Tue Dec 01 00:00:00 UTC 2020
c-FLIP is crucial for IL-7/IL-15-dependent NKp46+ ILC development and protection from intestinal inflammation in mice.
Nature communications
Bank U,Deiser K,Plaza-Sirvent C,Osbelt L,Witte A,Knop L,Labrenz R,Jänsch R,Richter F,Biswas A,Zenclussen AC,Vivier E,Romagnani C,Kühl AA,Dunay IR,Strowig T,Schmitz I,Schüler T
Wed Feb 26 00:00:00 UTC 2020
MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome.
Scientific reports
Stangl H,Krammetsvogl A,Lesiak M,Wolff C,Straub RH
Tue Oct 13 00:00:00 UTC 2020
CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs.
Cell reports
Jin J,Jung IH,Moon SH,Jeon S,Jeong SJ,Sonn SK,Seo S,Lee MN,Song EJ,Kweon HY,Kim S,Kim TK,Kim J,Cho HR,Choi JH,Kwon B,Oh GT
250-31L was used in In vitro experiments to define a mechanism of paracrine immunoregulation operating between adjacent DC subsets in the intestine.
Tue Mar 24 00:00:00 UTC 2020
Eosinophil accumulation in postnatal lung is specific to the primary septation phase of development.
Scientific reports
Loffredo LF,Coden ME,Jeong BM,Walker MT,Anekalla KR,Doan TC,Rodriguez R,Browning M,Nam K,Lee JJ,Abdala-Valencia H,Berdnikovs S
Tue Mar 10 00:00:00 UTC 2020
Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition.
Nature communications
Oatley M,Bölükbası ÖV,Svensson V,Shvartsman M,Ganter K,Zirngibl K,Pavlovich PV,Milchevskaya V,Foteva V,Natarajan KN,Baying B,Benes V,Patil KR,Teichmann SA,Lancrin C
250-31L was used in In vitro experiments to demonstrate that by inhibiting the interaction between CD44 and its ligand hyaluronan, we can block EHT, identifying an additional regulator of HSPC development.
Wed Jan 29 00:00:00 UTC 2020
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death.
Nature communications
Hayashi K,Nikolos F,Lee YC,Jain A,Tsouko E,Gao H,Kasabyan A,Leung HE,Osipov A,Jung SY,Kurtova AV,Chan KS
Mon Dec 07 00:00:00 UTC 2020
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
250-31L was used in Cell Culture to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 UTC 2021
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Proceedings of the National Academy of Sciences of the United States of America
Scholz F,Grau M,Menzel L,Graband A,Zapukhlyak M,Leutz A,Janz M,Lenz G,Rehm A,Höpken UE
Tue Oct 20 00:00:00 UTC 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
250-31L was used in Cell Culture to conclude that M-ATOs represent a highly reproducible and efficient experimental platform for the interrogation of clonal thymopoiesis from HSCs.
Tue Oct 27 00:00:00 UTC 2020
In Vitro Recapitulation of Murine Thymopoiesis from Single Hematopoietic Stem Cells.
Cell reports
Montel-Hagen A,Sun V,Casero D,Tsai S,Zampieri A,Jackson N,Li S,Lopez S,Zhu Y,Chick B,He C,de Barros SC,Seet CS,Crooks GM
250-31L was used in Cell Culture to conclude that M-ATOs represent a highly reproducible and efficient experimental platform for the interrogation of clonal thymopoiesis from HSCs.
Tue Oct 27 00:00:00 UTC 2020
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species.
Science advances
Kong H,Reczek CR,McElroy GS,Steinert EM,Wang T,Sabatini DM,Chandel NS
250-31L was used in Cell Culture to demonstrate that mitochondrial complex I is a dominant metabolic determinant of mROS-dependent cellular fitness, using mitochondria-targeted antioxidants (MVE or MitoTEMPO) to pharmcologically inhibit mitochondrial complex I.
Sun Nov 01 00:00:00 UTC 2020
Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells.
Immunity
Mariani SA,Li Z,Rice S,Krieg C,Fragkogianni S,Robinson M,Vink CS,Pollard JW,Dzierzak E
Tue Jun 18 00:00:00 UTC 2019
Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT.
Immunity
Chopin M,Lun AT,Zhan Y,Schreuder J,Coughlan H,D'Amico A,Mielke LA,Almeida FF,Kueh AJ,Dickins RA,Belz GT,Naik SH,Lew AM,Bouillet P,Herold MJ,Smyth GK,Corcoran LM,Nutt SL
Tue Jan 15 00:00:00 UTC 2019
A role for macrophages in hematopoiesis in the embryonic head.
Blood
Li Z,Mariani SA,Rodriguez-Seoane C,He W,Ning X,Liu B,Vink CS,Dzierzak E
Thu Nov 28 00:00:00 UTC 2019
TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.
Cell stem cell
Yamashita M,Passegué E
250-31L was used in Cell Culture to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.
Thu Sep 05 00:00:00 UTC 2019
Chimeric antigen receptor-induced BCL11B suppression propagates NK-like cell development.
The Journal of clinical investigation
Maluski M,Ghosh A,Herbst J,Scholl V,Baumann R,Huehn J,Geffers R,Meyer J,Maul H,Eiz-Vesper B,Krueger A,Schambach A,van den Brink MR,Sauer MG
Mon Dec 02 00:00:00 UTC 2019
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35.
The Journal of clinical investigation
Koda Y,Nakamoto N,Chu PS,Ugamura A,Mikami Y,Teratani T,Tsujikawa H,Shiba S,Taniki N,Sujino T,Miyamoto K,Suzuki T,Yamaguchi A,Morikawa R,Sato K,Sakamoto M,Yoshimoto T,Kanai T
Tue Jul 02 00:00:00 UTC 2019
CD97 is a critical regulator of acute myeloid leukemia stem cell function.
The Journal of experimental medicine
Martin GH,Roy N,Chakraborty S,Desrichard A,Chung SS,Woolthuis CM,Hu W,Berezniuk I,Garrett-Bakelman FE,Hamann J,Devlin SM,Chan TA,Park CY
Mon Oct 07 00:00:00 UTC 2019
Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors.
The Journal of experimental medicine
Yokomizo T,Watanabe N,Umemoto T,Matsuo J,Harai R,Kihara Y,Nakamura E,Tada N,Sato T,Takaku T,Shimono A,Takizawa H,Nakagata N,Mori S,Kurokawa M,Tenen DG,Osato M,Suda T,Komatsu N
Mon Jul 01 00:00:00 UTC 2019
Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection.
Proceedings of the National Academy of Sciences of the United States of America
Zheng M,Li D,Zhao Z,Shytikov D,Xu Q,Jin X,Liang J,Lou J,Wu S,Wang L,Hu H,Zhou Y,Gao X,Lu L
Tue Jun 18 00:00:00 UTC 2019
Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging.
Cell reports
Luo H,Mu WC,Karki R,Chiang HH,Mohrin M,Shin JJ,Ohkubo R,Ito K,Kanneganti TD,Chen D
250-31L was used in Cell Culture to assess whether the NLRP3 inflammasome is aberrantly activated in haematopoietic stem cells during physiological ageing.
Tue Jan 22 00:00:00 UTC 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 UTC 2019
Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development.
Scientific reports
Abramowitz LK,Harly C,Das A,Bhandoola A,Hanover JA
Thu Aug 29 00:00:00 UTC 2019
SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness.
Scientific reports
Nguyen CH,Glüxam T,Schlerka A,Bauer K,Grandits AM,Hackl H,Dovey O,Zöchbauer-Müller S,Cooper JL,Vassiliou GS,Stoiber D,Wieser R,Heller G
Mon Jun 24 00:00:00 UTC 2019
Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells.
Nature communications
Wang Y,Lu T,Sun G,Zheng Y,Yang S,Zhang H,Hao S,Liu Y,Ma S,Zhang H,Ru Y,Gao S,Yen K,Cheng H,Cheng T
Fri Dec 06 00:00:00 UTC 2019
Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis.
Stem cell reports
Lin Y,Kobayashi M,Azevedo Portilho N,Mishra A,Gao H,Liu Y,Wenzel P,Davis B,Yoder MC,Yoshimoto M
Tue Mar 05 00:00:00 UTC 2019
OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Nature
Heger K,Wickliffe KE,Ndoja A,Zhang J,Murthy A,Dugger DL,Maltzman A,de Sousa E Melo F,Hung J,Zeng Y,Verschueren E,Kirkpatrick DS,Vucic D,Lee WP,Roose-Girma M,Newman RJ,Warming S,Hsiao YC,Kőműves LG,Webster JD,Newton K,Dixit VM
Sun Jul 01 00:00:00 UTC 2018
Clonal analysis of lineage fate in native haematopoiesis.
Nature
Rodriguez-Fraticelli AE,Wolock SL,Weinreb CS,Panero R,Patel SH,Jankovic M,Sun J,Calogero RA,Klein AM,Camargo FD
Thu Jan 11 00:00:00 UTC 2018
Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation.
Immunity
Ohto U,Ishida H,Shibata T,Sato R,Miyake K,Shimizu T
Tue Apr 17 00:00:00 UTC 2018
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.
Immunity
Postat J,Olekhnovitch R,Lemaître F,Bousso P
Tue Oct 16 00:00:00 UTC 2018
Transfer of Cell-Surface Antigens by Scavenger Receptor CD36 Promotes Thymic Regulatory T Cell Receptor Repertoire Development and Allo-tolerance.
Immunity
Perry JSA,Russler-Germain EV,Zhou YW,Purtha W,Cooper ML,Choi J,Schroeder MA,Salazar V,Egawa T,Lee BC,Abumrad NA,Kim BS,Anderson MS,DiPersio JF,Hsieh CS
Tue May 15 00:00:00 UTC 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
Tue Apr 17 00:00:00 UTC 2018
Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.
Cell stem cell
Duarte D,Hawkins ED,Akinduro O,Ang H,De Filippo K,Kong IY,Haltalli M,Ruivo N,Straszkowski L,Vervoort SJ,McLean C,Weber TS,Khorshed R,Pirillo C,Wei A,Ramasamy SK,Kusumbe AP,Duffy K,Adams RH,Purton LE,Carlin LM,Lo Celso C
250-31L was used in Cell Culture to suggest that preventing degradation of the endosteal vasculature may improve current paradigms for treating acute myeloid leukemia.
Thu Jan 04 00:00:00 UTC 2018
Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response.
The Journal of experimental medicine
Barbieri D,Elvira-Matelot E,Pelinski Y,Genève L,de Laval B,Yogarajah G,Pecquet C,Constantinescu SN,Porteu F
Mon May 07 00:00:00 UTC 2018
Altered compensatory cytokine signaling underlies the discrepancy between and mice.
The Journal of experimental medicine
Durai V,Bagadia P,Briseño CG,Theisen DJ,Iwata A,Davidson JT,Gargaro M,Fremont DH,Murphy TL,Murphy KM
Mon May 07 00:00:00 UTC 2018
Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1.
The Journal of experimental medicine
Tober J,Maijenburg MMW,Li Y,Gao L,Hadland BK,Gao P,Minoura K,Bernstein ID,Tan K,Speck NA
Mon Feb 05 00:00:00 UTC 2018
Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.
The Journal of experimental medicine
Jensen CT,Åhsberg J,Sommarin MNE,Strid T,Somasundaram R,Okuyama K,Ungerbäck J,Kupari J,Airaksinen MS,Lang S,Bryder D,Soneji S,Karlsson G,Sigvardsson M
Mon Jul 02 00:00:00 UTC 2018
Eosinophils suppress Th1 responses and restrict bacterially induced gastrointestinal inflammation.
The Journal of experimental medicine
Arnold IC,Artola-Borán M,Tallón de Lara P,Kyburz A,Taube C,Ottemann K,van den Broek M,Yousefi S,Simon HU,Müller A
Mon Aug 06 00:00:00 UTC 2018
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells.
Oncogene
Pinazza M,Ghisi M,Minuzzo S,Agnusdei V,Fossati G,Ciminale V,Pezzè L,Ciribilli Y,Pilotto G,Venturoli C,Amadori A,Indraccolo S
Sun Jul 01 00:00:00 UTC 2018
IL-36α from Skin-Resident Cells Plays an Important Role in the Pathogenesis of Imiquimod-Induced Psoriasiform Dermatitis by Forming a Local Autoamplification Loop.
Journal of immunology (Baltimore, Md. : 1950)
Hashiguchi Y,Yabe R,Chung SH,Murayama MA,Yoshida K,Matsuo K,Kubo S,Saijo S,Nakamura Y,Matsue H,Iwakura Y
Sun Jul 01 00:00:00 UTC 2018
TLR-7 Stress Signaling in Differentiating and Mature Eosinophils Is Mediated by the Prolyl Isomerase Pin1.
Journal of immunology (Baltimore, Md. : 1950)
Shen ZJ,Hu J,Kashi V,Bochkov YA,Gern JE,Malter JS
Sat Dec 15 00:00:00 UTC 2018
B Cell Development sans B Cell Receptor Responsiveness Due to Unfolded Protein Response-Triggered Mef2c Protein Degradation.
Journal of immunology (Baltimore, Md. : 1950)
Chen YT,Su YC,Kung JT
Thu Nov 15 00:00:00 UTC 2018
Identification of a Multipotent Progenitor Population in the Spleen That Is Regulated by NR4A1.
Journal of immunology (Baltimore, Md. : 1950)
Mumau MD,Vanderbeck AN,Lynch ED,Golec SB,Emerson SG,Punt JA
Thu Feb 01 00:00:00 UTC 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
Thu Feb 15 00:00:00 UTC 2018
CD40 Mediates Maturation of Thymic Dendritic Cells Driven by Self-Reactive CD4+ Thymocytes and Supports Development of Natural Regulatory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Oh J,Wu N,Barczak AJ,Barbeau R,Erle DJ,Shin JS
Thu Feb 15 00:00:00 UTC 2018
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.
Nature communications
Lopes N,Charaix J,Cédile O,Sergé A,Irla M
Wed Mar 28 00:00:00 UTC 2018
MicroRNA-143 targets ERK5 in granulopoiesis and predicts outcome of patients with acute myeloid leukemia.
Cell death & disease
Hartmann JU,Bräuer-Hartmann D,Kardosova M,Wurm AA,Wilke F,Schödel C,Gerloff D,Katzerke C,Krakowsky R,Namasu CY,Bill M,Schwind S,Müller-Tidow C,Niederwieser D,Alberich-Jorda M,Behre G
Thu Jul 26 00:00:00 UTC 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
250-31L was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 UTC 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity.
Cell stem cell
Giambra V,Gusscott S,Gracias D,Song R,Lam SH,Panelli P,Tyshchenko K,Jenkins CE,Hoofd C,Lorzadeh A,Carles A,Hirst M,Eaves CJ,Weng AP
250-31L was used in In vitro experiments to demonstrate that resurrecting dormant fetal programs in adult cells may represent an alternate therapeutic approach in human cancer.
Thu Nov 01 00:00:00 UTC 2018
Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.
Stem cell reports
Karatepe K,Zhu H,Zhang X,Guo R,Kambara H,Loison F,Liu P,Yu H,Ren Q,Luo X,Manis J,Cheng T,Ma F,Xu Y,Luo HR
Tue Nov 13 00:00:00 UTC 2018
Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression.
Nature communications
Calcinotto A,Brevi A,Chesi M,Ferrarese R,Garcia Perez L,Grioni M,Kumar S,Garbitt VM,Sharik ME,Henderson KJ,Tonon G,Tomura M,Miwa Y,Esplugues E,Flavell RA,Huber S,Canducci F,Rajkumar VS,Bergsagel PL,Bellone M
Mon Dec 03 00:00:00 UTC 2018
mTOR complexes differentially orchestrates eosinophil development in allergy.
Scientific reports
Zhu C,Xia L,Li F,Zhou L,Weng Q,Li Z,Wu Y,Mao Y,Zhang C,Wu Y,Li M,Ying S,Chen Z,Shen H,Li W
Wed May 02 00:00:00 UTC 2018
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs.
Nature communications
Ganuza M,Chabot A,Tang X,Bi W,Natarajan S,Carter R,Gawad C,Kang G,Cheng Y,McKinney-Freeman S
Thu Dec 20 00:00:00 UTC 2018
Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis.
Cell discovery
Rothberg JLM,Maganti HB,Jrade H,Porter CJ,Palidwor GA,Cafariello C,Battaion HL,Khan ST,Perkins TJ,Paulson RF,Ito CY,Stanford WL
Thu Aug 17 00:00:00 UTC 2023
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
Tue Jan 02 00:00:00 UTC 2018
UBXN3B positively regulates STING-mediated antiviral immune responses.
Nature communications
Yang L,Wang L,Ketkar H,Ma J,Yang G,Cui S,Geng T,Mordue DG,Fujimoto T,Cheng G,You F,Lin R,Fikrig E,Wang P
Wed Jun 13 00:00:00 UTC 2018
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
Tue Sep 11 00:00:00 UTC 2018
Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice.
Communications biology
Willetts L,Felix LC,Jacobsen EA,Puttagunta L,Condjella RM,Zellner KR,Ochkur SI,Kim JD,Luo H,Lee NA,Lee JJ,Moqbel R,Lacy P
Sat Jan 11 00:00:00 UTC 2020
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 UTC 2018
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
250-31L was used in In vitro experiments to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 UTC 2017
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Immunity
Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C
Tue May 16 00:00:00 UTC 2017
MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.
Cancer cell
Chen Y,Anastassiadis K,Kranz A,Stewart AF,Arndt K,Waskow C,Yokoyama A,Jones K,Neff T,Lee Y,Ernst P
Mon Jun 12 00:00:00 UTC 2017
CSF-1-induced Src signaling can instruct monocytic lineage choice.
Blood
Endele M,Loeffler D,Kokkaliaris KD,Hilsenbeck O,Skylaki S,Hoppe PS,Schambach A,Stanley ER,Schroeder T
Thu Mar 23 00:00:00 UTC 2017
Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies.
The Journal of experimental medicine
Tanaka T,Nakajima-Takagi Y,Aoyama K,Tara S,Oshima M,Saraya A,Koide S,Si S,Manabe I,Sanada M,Nakayama M,Masuko M,Sone H,Koseki H,Iwama A
Mon Oct 02 00:00:00 UTC 2017
PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.
The Journal of experimental medicine
Wiede F,Dudakov JA,Lu KH,Dodd GT,Butt T,Godfrey DI,Strasser A,Boyd RL,Tiganis T
Mon Sep 04 00:00:00 UTC 2017
Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.
The Journal of experimental medicine
Uderhardt S,Ackermann JA,Fillep T,Hammond VJ,Willeit J,Santer P,Mayr M,Biburger M,Miller M,Zellner KR,Stark K,Zarbock A,Rossaint J,Schubert I,Mielenz D,Dietel B,Raaz-Schrauder D,Ay C,Gremmel T,Thaler J,Heim C,Herrmann M,Collins PW,Schabbauer G,Mackman N,Voehringer D,Nadler JL,Lee JJ,Massberg S,Rauh M,Kiechl S,Schett G,O'Donnell VB,Krönke G
Mon Jul 03 00:00:00 UTC 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
Mon Dec 04 00:00:00 UTC 2017
Type I interferon is required for T helper (Th) 2 induction by dendritic cells.
The EMBO journal
Webb LM,Lundie RJ,Borger JG,Brown SL,Connor LM,Cartwright AN,Dougall AM,Wilbers RH,Cook PC,Jackson-Jones LH,Phythian-Adams AT,Johansson C,Davis DM,Dewals BG,Ronchese F,MacDonald AS
Tue Aug 15 00:00:00 UTC 2017
Generation of an osteoblast-based artificial niche that supports in vitro B lymphopoiesis.
Experimental & molecular medicine
Yu J,Choi S,Kim H,Lee N,Yun H,Kim S,Jeong ST,Rho J
Fri Nov 24 00:00:00 UTC 2017
Eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2-/- mice.
Mucosal immunology
Verma AH,Bueter CL,Rothenberg ME,Deepe GS
Sun Jan 01 00:00:00 UTC 2017
Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA.
European journal of immunology
McGlasson SL,Semple F,MacPherson H,Gray M,Davidson DJ,Dorin JR
Sat Apr 01 00:00:00 UTC 2017
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.
Journal of immunology (Baltimore, Md. : 1950)
Falahee PC,Anderson LS,Reynolds MB,Pirir M,McLaughlin BE,Dillen CA,Cheung AL,Miller LS,Simon SI
Fri Sep 01 00:00:00 UTC 2017
Monitoring C5aR2 Expression Using a Floxed tdTomato-C5aR2 Knock-In Mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Wiese AV,Mey F,Figge J,Woodruff TM,Reuter T,Scurtu O,Kordowski A,Almeida LN,Briukhovetska D,Quell KM,Sun J,Ender F,Schmudde I,Vollbrandt T,Laumonnier Y,Köhl J
Wed Nov 01 00:00:00 UTC 2017
Mer Receptor Tyrosine Kinase Signaling Prevents Self-Ligand Sensing and Aberrant Selection in Germinal Centers.
Journal of immunology (Baltimore, Md. : 1950)
Schell SL,Soni C,Fasnacht MJ,Domeier PP,Cooper TK,Rahman ZSM
Fri Dec 15 00:00:00 UTC 2017
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Moore MA,van den Brink MRM,Kusunoki Y
Sun Oct 15 00:00:00 UTC 2017
TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.
Nature communications
Saitoh SI,Abe F,Kanno A,Tanimura N,Mori Saitoh Y,Fukui R,Shibata T,Sato K,Ichinohe T,Hayashi M,Kubota K,Kozuka-Hata H,Oyama M,Kikko Y,Katada T,Kontani K,Miyake K
Fri Nov 17 00:00:00 UTC 2017
Structural Determinants of the Gain-of-Function Phenotype of Human Leukemia-associated Mutant CBL Oncogene.
The Journal of biological chemistry
Nadeau SA,An W,Mohapatra BC,Mushtaq I,Bielecki TA,Luan H,Zutshi N,Ahmad G,Storck MD,Sanada M,Ogawa S,Band V,Band H
Fri Mar 03 00:00:00 UTC 2017
CD300f:IL-5 cross-talk inhibits adipose tissue eosinophil homing and subsequent IL-4 production.
Scientific reports
Rozenberg P,Reichman H,Zab-Bar I,Itan M,Pasmanik-Chor M,Bouffi C,Qimron U,Bachelet I,Fulkerson PC,Rothenberg ME,Munitz A
Wed Jul 19 00:00:00 UTC 2017
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Nature biotechnology
Stevens MM,Maire CL,Chou N,Murakami MA,Knoff DS,Kikuchi Y,Kimmerling RJ,Liu H,Haidar S,Calistri NL,Cermak N,Olcum S,Cordero NA,Idbaih A,Wen PY,Weinstock DM,Ligon KL,Manalis SR
250-31L was used in In vitro experiments to investigate assays for tumour cell therapeutic response.
Tue Nov 01 00:00:00 UTC 2016
Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function.
Immunity
Wu D,Sanin DE,Everts B,Chen Q,Qiu J,Buck MD,Patterson A,Smith AM,Chang CH,Liu Z,Artyomov MN,Pearce EL,Cella M,Pearce EJ
Tue Jun 21 00:00:00 UTC 2016
Cystatin F Ensures Eosinophil Survival by Regulating Granule Biogenesis.
Immunity
Matthews SP,McMillan SJ,Colbert JD,Lawrence RA,Watts C
Tue Apr 19 00:00:00 UTC 2016
AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.
Cell metabolism
Kishton RJ,Barnes CE,Nichols AG,Cohen S,Gerriets VA,Siska PJ,Macintyre AN,Goraksha-Hicks P,de Cubas AA,Liu T,Warmoes MO,Abel ED,Yeoh AE,Gershon TR,Rathmell WK,Richards KL,Locasale JW,Rathmell JC
250-31L was used in Cell Culture to study to what extent the leukemic T cell populations are metabolically similar and if differences reveal T cell acute lymphoblastic leukemia (T-ALL) vulnerabilities.
Tue Apr 12 00:00:00 UTC 2016
GATA2 regulates dendritic cell differentiation.
Blood
Onodera K,Fujiwara T,Onishi Y,Itoh-Nakadai A,Okitsu Y,Fukuhara N,Ishizawa K,Shimizu R,Yamamoto M,Harigae H
Thu Jul 28 00:00:00 UTC 2016
Developing HSCs become Notch independent by the end of maturation in the AGM region.
Blood
Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A
Thu Sep 22 00:00:00 UTC 2016
MicroRNA-139-5p regulates proliferation of hematopoietic progenitors and is repressed during BCR-ABL-mediated leukemogenesis.
Blood
Choi J,Kim YK,Park K,Nah J,Yoon SS,Kim DW,Kim VN,Seong RH
Thu Oct 27 00:00:00 UTC 2016
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
Fri Jan 01 00:00:00 UTC 2016
Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging.
The Journal of experimental medicine
Young K,Borikar S,Bell R,Kuffler L,Philip V,Trowbridge JJ
Mon Oct 17 00:00:00 UTC 2016
Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.
The Journal of experimental medicine
Lau CM,Nish SA,Yogev N,Waisman A,Reiner SL,Reizis B
Mon Mar 07 00:00:00 UTC 2016
IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.
EMBO molecular medicine
Davidson S,McCabe TM,Crotta S,Gad HH,Hessel EM,Beinke S,Hartmann R,Wack A
Thu Sep 01 00:00:00 UTC 2016
CXCR4 Signaling Negatively Modulates the Bipotential State of Hemogenic Endothelial Cells Derived from Embryonic Stem Cells by Attenuating the Endothelial Potential.
Stem cells (Dayton, Ohio)
Ahmed T,Tsuji-Tamura K,Ogawa M
Thu Dec 01 00:00:00 UTC 2016
Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth.
Journal of immunology (Baltimore, Md. : 1950)
Kim J,Kim W,Moon UJ,Kim HJ,Choi HJ,Sin JI,Park NH,Cho HR,Kwon B
Tue Mar 01 00:00:00 UTC 2016
Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus.
Journal of immunology (Baltimore, Md. : 1950)
Lam T,Kulp DV,Wang R,Lou Z,Taylor J,Rivera CE,Yan H,Zhang Q,Wang Z,Zan H,Ivanov DN,Zhong G,Casali P,Xu Z
Tue Nov 15 00:00:00 UTC 2016
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Journal of immunology (Baltimore, Md. : 1950)
Boucard-Jourdin M,Kugler D,Endale Ahanda ML,This S,De Calisto J,Zhang A,Mora JR,Stuart LM,Savill J,Lacy-Hulbert A,Paidassi H
Thu Sep 01 00:00:00 UTC 2016
CLIC1 regulates dendritic cell antigen processing and presentation by modulating phagosome acidification and proteolysis.
Biology open
Salao K,Jiang L,Li H,Tsai VW,Husaini Y,Curmi PM,Brown LJ,Brown DA,Breit SN
250-31L was used in Cell Culture to suggest that CLIC1 regulates DC phagosomal pH to ensure optimal processing of antigen for presentation to antigen-specific T-cells.
Sun May 15 00:00:00 UTC 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
Tue Mar 08 00:00:00 UTC 2016
The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells.
The Journal of biological chemistry
Kralova J,Fabisik M,Pokorna J,Skopcova T,Malissen B,Brdicka T
Fri Aug 05 00:00:00 UTC 2016
The Balance between Conventional DCs and Plasmacytoid DCs Is Pivotal for Immunological Tolerance during Pregnancy in the Mouse.
Scientific reports
Fang WN,Shi M,Meng CY,Li DD,Peng JP
Fri May 27 00:00:00 UTC 2016
Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.
Cell death & disease
Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH
Thu Apr 07 00:00:00 UTC 2016
Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.
Nature communications
den Brok MH,Büll C,Wassink M,de Graaf AM,Wagenaars JA,Minderman M,Thakur M,Amigorena S,Rijke EO,Schrier CC,Adema GJ
Mon Nov 07 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model.
Cell death & disease
Tong KI,Ota K,Komuro A,Ueda T,Ito A,Anne Koch C,Okada H
Thu Oct 06 00:00:00 UTC 2016
Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity.
Scientific reports
Haque M,Song J,Fino K,Sandhu P,Song X,Lei F,Zheng S,Ni B,Fang D,Song J
Fri Feb 05 00:00:00 UTC 2016
B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia.
The Journal of biological chemistry
Imoto N,Hayakawa F,Kurahashi S,Morishita T,Kojima Y,Yasuda T,Sugimoto K,Tsuzuki S,Naoe T,Kiyoi H
Fri Feb 26 00:00:00 UTC 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
Thu Jun 02 00:00:00 UTC 2016
EphrinB2 regulates the emergence of a hemogenic endothelium from the aorta.
Scientific reports
Chen II,Caprioli A,Ohnuki H,Kwak H,Porcher C,Tosato G
Thu Jun 02 00:00:00 UTC 2016
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.
Nature communications
Lai M,Gonzalez-Martin A,Cooper AB,Oda H,Jin HY,Shepherd J,He L,Zhu J,Nemazee D,Xiao C
Tue Aug 02 00:00:00 UTC 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
Mon May 23 00:00:00 UTC 2016
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature communications
Gu Z,Churchman M,Roberts K,Li Y,Liu Y,Harvey RC,McCastlain K,Reshmi SC,Payne-Turner D,Iacobucci I,Shao Y,Chen IM,Valentine M,Pei D,Mungall KL,Mungall AJ,Ma Y,Moore R,Marra M,Stonerock E,Gastier-Foster JM,Devidas M,Dai Y,Wood B,Borowitz M,Larsen EE,Maloney K,Mattano LA,Angiolillo A,Salzer WL,Burke MJ,Gianni F,Spinelli O,Radich JP,Minden MD,Moorman AV,Patel B,Fielding AK,Rowe JM,Luger SM,Bhatia R,Aldoss I,Forman SJ,Kohlschmidt J,Mrózek K,Marcucci G,Bloomfield CD,Stock W,Kornblau S,Kantarjian HM,Konopleva M,Paietta E,Willman CL,Loh ML,Hunger SP,Mullighan CG
Tue Nov 08 00:00:00 UTC 2016
Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.
Nature communications
Hu X,Garcia M,Weng L,Jung X,Murakami JL,Kumar B,Warden CD,Todorov I,Chen CC
Mon Oct 10 00:00:00 UTC 2016
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.
The Journal of clinical investigation
Park SM,Gönen M,Vu L,Minuesa G,Tivnan P,Barlowe TS,Taggart J,Lu Y,Deering RP,Hacohen N,Figueroa ME,Paietta E,Fernandez HF,Tallman MS,Melnick A,Levine R,Leslie C,Lengner CJ,Kharas MG
Mon Mar 02 00:00:00 UTC 2015
Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells.
The Journal of clinical investigation
Hadland BK,Varnum-Finney B,Poulos MG,Moon RT,Butler JM,Rafii S,Bernstein ID
Fri May 01 00:00:00 UTC 2015
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
The Journal of clinical investigation
Duque-Afonso J,Feng J,Scherer F,Lin CH,Wong SH,Wang Z,Iwasaki M,Cleary ML
Tue Sep 01 00:00:00 UTC 2015
Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.
The Journal of experimental medicine
Ungerbäck J,Åhsberg J,Strid T,Somasundaram R,Sigvardsson M
Mon Jun 29 00:00:00 UTC 2015
Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages.
The Journal of experimental medicine
Xia P,Wang S,Du Y,Huang G,Satoh T,Akira S,Fan Z
Mon Dec 14 00:00:00 UTC 2015
CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo.
The Journal of experimental medicine
Mende N,Kuchen EE,Lesche M,Grinenko T,Kokkaliaris KD,Hanenberg H,Lindemann D,Dahl A,Platz A,Höfer T,Calegari F,Waskow C
Mon Jul 27 00:00:00 UTC 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
250-31L was used in Sample Preparation (FC/FACS) to represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.
Mon Oct 19 00:00:00 UTC 2015
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms.
The Journal of experimental medicine
Mullenders J,Aranda-Orgilles B,Lhoumaud P,Keller M,Pae J,Wang K,Kayembe C,Rocha PP,Raviram R,Gong Y,Premsrirut PK,Tsirigos A,Bonneau R,Skok JA,Cimmino L,Hoehn D,Aifantis I
250-31L was used in Sample Preparation (FC/FACS) to represent the first successful demonstration of a tumor suppressor function for the cohesin complex, while also confirming that cohesin mutations occur as an early event in leukemogenesis, facilitating the potential development of a myeloid malignancy.
Mon Oct 19 00:00:00 UTC 2015
Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma.
Proceedings of the National Academy of Sciences of the United States of America
Lee J,Kim TH,Murray F,Li X,Choi SS,Broide DH,Corr M,Lee J,Webster NJ,Insel PA,Raz E
Tue Feb 03 00:00:00 UTC 2015
Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.
Proceedings of the National Academy of Sciences of the United States of America
Godec J,Cowley GS,Barnitz RA,Alkan O,Root DE,Sharpe AH,Haining WN
Tue Jan 13 00:00:00 UTC 2015
Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.
Proceedings of the National Academy of Sciences of the United States of America
Lin D,Zhang M,Zhang MX,Ren Y,Jin J,Zhao Q,Pan Z,Wu M,Shu HB,Dong C,Zhong B
Tue Sep 08 00:00:00 UTC 2015
Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Stem cells (Dayton, Ohio)
Zeng Y,Broxmeyer HE,Staser K,Chitteti BR,Park SJ,Hahn S,Cooper S,Sun Z,Jiang L,Yang X,Yuan J,Kosoff R,Sandusky G,Srour EF,Chernoff J,Clapp DW
Fri May 01 00:00:00 UTC 2015
Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.
Journal of immunology (Baltimore, Md. : 1950)
Krishnamoorthy V,Carr T,de Pooter RF,Emanuelle AO,Gounari F,Kee BL
Wed Apr 01 00:00:00 UTC 2015
Beta-catenin signaling drives differentiation and proinflammatory function of IRF8-dependent dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Cohen SB,Smith NL,McDougal C,Pepper M,Shah S,Yap GS,Acha-Orbea H,Jiang A,Clausen BE,Rudd BD,Denkers EY
Thu Jan 01 00:00:00 UTC 2015
Eosinophils Contribute to Early Clearance of Pneumocystis murina Infection.
Journal of immunology (Baltimore, Md. : 1950)
Eddens T,Elsegeiny W,Nelson MP,Horne W,Campfield BT,Steele C,Kolls JK
Wed Jul 01 00:00:00 UTC 2015
Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.
Molecular therapy. Methods & clinical development
Ungari S,Montepeloso A,Morena F,Cocchiarella F,Recchia A,Martino S,Gentner B,Naldini L,Biffi A
Wed Oct 28 00:00:00 UTC 2015
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion.
Scientific reports
Xie XQ,Yang P,Zhang Y,Zhang P,Wang L,Ding Y,Yang M,Tong Q,Cheng H,Ji Q,McGuire T,Yuan W,Cheng T,Gao Y
Fri Dec 18 00:00:00 UTC 2015
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.
Nature communications
Alvarez S,Díaz M,Flach J,Rodriguez-Acebes S,López-Contreras AJ,Martínez D,Cañamero M,Fernández-Capetillo O,Isern J,Passegué E,Méndez J
Mon Oct 12 00:00:00 UTC 2015
The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.
Stem cell reports
Zhang J,Vakhrusheva O,Bandi SR,Demirel Ö,Kazi JU,Fernandes RG,Jakobi K,Eichler A,Rönnstrand L,Rieger MA,Carpino N,Serve H,Brandts CH
Tue Oct 13 00:00:00 UTC 2015
Role of Erk1/2 signaling in the regulation of neutrophil versus monocyte development in response to G-CSF and M-CSF.
The Journal of biological chemistry
Hu N,Qiu Y,Dong F
Fri Oct 02 00:00:00 UTC 2015
Autophagy confers DNA damage repair pathways to protect the hematopoietic system from nuclear radiation injury.
Scientific reports
Lin W,Yuan N,Wang Z,Cao Y,Fang Y,Li X,Xu F,Song L,Wang J,Zhang H,Yan L,Xu L,Zhang X,Zhang S,Wang J
Tue Jul 21 00:00:00 UTC 2015
L-Myc expression by dendritic cells is required for optimal T-cell priming.
Nature
KC W,Satpathy AT,Rapaport AS,Briseño CG,Wu X,Albring JC,Russler-Germain EV,Kretzer NM,Durai V,Persaud SP,Edelson BT,Loschko J,Cella M,Allen PM,Nussenzweig MC,Colonna M,Sleckman BP,Murphy TL,Murphy KM
Thu Mar 13 00:00:00 UTC 2014
Nonstochastic reprogramming from a privileged somatic cell state.
Cell
Guo S,Zi X,Schulz VP,Cheng J,Zhong M,Koochaki SH,Megyola CM,Pan X,Heydari K,Weissman SM,Gallagher PG,Krause DS,Fan R,Lu J
Thu Feb 13 00:00:00 UTC 2014
Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Blood
Lu EP,McLellan M,Ding L,Fulton R,Mardis ER,Wilson RK,Miller CA,Westervelt P,DiPersio JF,Link DC,Walter MJ,Ley TJ,Graubert TA
Thu Dec 18 00:00:00 UTC 2014
Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-κB pathways and their target, IEX-1.
Blood
de Laval B,Pawlikowska P,Barbieri D,Besnard-Guerin C,Cico A,Kumar R,Gaudry M,Baud V,Porteu F
Thu Jan 23 00:00:00 UTC 2014
Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.
The Journal of clinical investigation
Sungalee S,Mamessier E,Morgado E,Grégoire E,Brohawn PZ,Morehouse CA,Jouve N,Monvoisin C,Menard C,Debroas G,Faroudi M,Mechin V,Navarro JM,Drevet C,Eberle FC,Chasson L,Baudimont F,Mancini SJ,Tellier J,Picquenot JM,Kelly R,Vineis P,Ruminy P,Chetaille B,Jaffe ES,Schiff C,Hardwigsen J,Tice DA,Higgs BW,Tarte K,Nadel B,Roulland S
Mon Dec 01 00:00:00 UTC 2014
Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
The Journal of clinical investigation
Bestas B,Moreno PM,Blomberg KE,Mohammad DK,Saleh AF,Sutlu T,Nordin JZ,Guterstam P,Gustafsson MO,Kharazi S,Piątosa B,Roberts TC,Behlke MA,Wood MJ,Gait MJ,Lundin KE,El Andaloussi S,Månsson R,Berglöf A,Wengel J,Smith CI
Mon Sep 01 00:00:00 UTC 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
Mon Apr 07 00:00:00 UTC 2014
Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.
The Journal of experimental medicine
Lancini C,van den Berk PC,Vissers JH,Gargiulo G,Song JY,Hulsman D,Serresi M,Tanger E,Blom M,Vens C,van Lohuizen M,Jacobs H,Citterio E
Mon Aug 25 00:00:00 UTC 2014
Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
The Journal of experimental medicine
Pietras EM,Lakshminarasimhan R,Techner JM,Fong S,Flach J,Binnewies M,Passegué E
Mon Feb 10 00:00:00 UTC 2014
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia.
The Journal of experimental medicine
Järås M,Miller PG,Chu LP,Puram RV,Fink EC,Schneider RK,Al-Shahrour F,Peña P,Breyfogle LJ,Hartwell KA,McConkey ME,Cowley GS,Root DE,Kharas MG,Mullally A,Ebert BL
Mon Apr 07 00:00:00 UTC 2014
Leucine-rich repeat containing 8A (LRRC8A) is essential for T lymphocyte development and function.
The Journal of experimental medicine
Kumar L,Chou J,Yee CS,Borzutzky A,Vollmann EH,von Andrian UH,Park SY,Hollander G,Manis JP,Poliani PL,Geha RS
Mon May 05 00:00:00 UTC 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Mon Sep 22 00:00:00 UTC 2014
Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
The Journal of experimental medicine
Gazit R,Mandal PK,Ebina W,Ben-Zvi A,Nombela-Arrieta C,Silberstein LE,Rossi DJ
Mon Jun 30 00:00:00 UTC 2014
High c-Kit expression identifies hematopoietic stem cells with impaired self-renewal and megakaryocytic bias.
The Journal of experimental medicine
Shin JY,Hu W,Naramura M,Park CY
Mon Feb 10 00:00:00 UTC 2014
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development.
Proceedings of the National Academy of Sciences of the United States of America
Kobayashi M,Shelley WC,Seo W,Vemula S,Lin Y,Liu Y,Kapur R,Taniuchi I,Yoshimoto M
Tue Aug 19 00:00:00 UTC 2014
PDK1 regulates B cell differentiation and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Baracho GV,Cato MH,Zhu Z,Jaren OR,Hobeika E,Reth M,Rickert RC
Tue Jul 01 00:00:00 UTC 2014
Effect of NS-018, a selective JAK2V617F inhibitor, in a murine model of myelofibrosis.
Blood cancer journal
Nakaya Y,Shide K,Naito H,Niwa T,Horio T,Miyake J,Shimoda K
Fri Jan 10 00:00:00 UTC 2014
Identification of multipotent progenitors that emerge prior to hematopoietic stem cells in embryonic development.
Stem cell reports
Inlay MA,Serwold T,Mosley A,Fathman JW,Dimov IK,Seita J,Weissman IL
250-31L was used in Sample Preparation (FC/FACS) to develop a single-cell multipotency assay which can be used to identify when and where clonal multilineage potential arises during embryogenesis.
Tue Apr 08 00:00:00 UTC 2014
Dendritic cell development requires histone deacetylase activity.
European journal of immunology
Chauvistré H,Küstermann C,Rehage N,Klisch T,Mitzka S,Felker P,Rose-John S,Zenke M,Seré KM
Fri Aug 01 00:00:00 UTC 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
Wed Jan 01 00:00:00 UTC 2014
Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils.
Journal of immunology (Baltimore, Md. : 1950)
Wen T,Mingler MK,Wahl B,Khorki ME,Pabst O,Zimmermann N,Rothenberg ME
Sun Jun 15 00:00:00 UTC 2014
Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Swiecki M,Wang Y,Riboldi E,Kim AH,Dzutsev A,Gilfillan S,Vermi W,Ruedl C,Trinchieri G,Colonna M
Thu May 01 00:00:00 UTC 2014
Linkage between dendritic and T cell commitments in human circulating hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sun Jun 15 00:00:00 UTC 2014
Independent of plasmacytoid dendritic cell (pDC) infection, pDC triggered by virus-infected cells mount enhanced type I IFN responses of different composition as opposed to pDC stimulated with free virus.
Journal of immunology (Baltimore, Md. : 1950)
Frenz T,Graalmann L,Detje CN,Döring M,Grabski E,Scheu S,Kalinke U
Mon Sep 01 00:00:00 UTC 2014
Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Cuda CM,Misharin AV,Gierut AK,Saber R,Haines GK,Hutcheson J,Hedrick SM,Mohan C,Budinger GS,Stehlik C,Perlman H
Sun Jun 15 00:00:00 UTC 2014
Bone Marrow Derived Eosinophil Cultures.
Bio-protocol
Lu TX,Rothenberg ME
250-31L was used in Cell Culture to describe how bone marrow derived eosinophils are fully differentiated at the end of a 14 day culture based on morphology and expression of molecular markers.
Fri Jun 20 00:00:00 UTC 2014
The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.
Cell death & disease
Becker MS,Schmezer P,Breuer R,Haas SF,Essers MA,Krammer PH,Li-Weber M
Thu Jan 16 00:00:00 UTC 2014
CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling.
Cell death & disease
Ho KC,Chiang YJ,Lai AC,Liao NS,Chang YJ,Yang-Yen HF,Yen JJ
Thu Nov 13 00:00:00 UTC 2014
Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
The Journal of biological chemistry
Kuriakose T,Rada B,Watford WT
Fri Dec 26 00:00:00 UTC 2014
FOXO3A directs a protective autophagy program in haematopoietic stem cells.
Nature
Warr MR,Binnewies M,Flach J,Reynaud D,Garg T,Malhotra R,Debnath J,Passegué E
Thu Feb 21 00:00:00 UTC 2013
Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis.
Blood
Mildner A,Chapnik E,Manor O,Yona S,Kim KW,Aychek T,Varol D,Beck G,Itzhaki ZB,Feldmesser E,Amit I,Hornstein E,Jung S
Thu Feb 07 00:00:00 UTC 2013
Interferon-γ impairs proliferation of hematopoietic stem cells in mice.
Blood
de Bruin AM,Demirel Ö,Hooibrink B,Brandts CH,Nolte MA
Thu May 02 00:00:00 UTC 2013
CD8α+ DCs can be induced in the absence of transcription factors Id2, Nfil3, and Batf3.
Blood
Seillet C,Jackson JT,Markey KA,Brady HJ,Hill GR,Macdonald KP,Nutt SL,Belz GT
Thu Feb 28 00:00:00 UTC 2013
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Blood
Shieh A,Ward AF,Donlan KL,Harding-Theobald ER,Xu J,Mullighan CG,Zhang C,Chen SC,Su X,Downing JR,Bollag GE,Shannon KM
Thu Jun 13 00:00:00 UTC 2013
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
Blood
Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A
Thu Oct 03 00:00:00 UTC 2013
Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells.
Blood
Matsushima H,Geng S,Lu R,Okamoto T,Yao Y,Mayuzumi N,Kotol PF,Chojnacki BJ,Miyazaki T,Gallo RL,Takashima A
Thu Mar 07 00:00:00 UTC 2013
Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica.
The Journal of clinical investigation
Zhang H,Verkman AS
Wed May 01 00:00:00 UTC 2013
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
The Journal of clinical investigation
Martin H,Mali RS,Ma P,Chatterjee A,Ramdas B,Sims E,Munugalavadla V,Ghosh J,Mattingly RR,Visconte V,Tiu RV,Vlaar CP,Dharmawardhane S,Kapur R
Tue Oct 01 00:00:00 UTC 2013
Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Wen T,Besse JA,Mingler MK,Fulkerson PC,Rothenberg ME
Tue Apr 09 00:00:00 UTC 2013
Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fukasaka M,Ori D,Kawagoe T,Uematsu S,Maruyama K,Okazaki T,Kozaki T,Imamura T,Tartey S,Mino T,Satoh T,Akira S,Takeuchi O
Sat Jun 01 00:00:00 UTC 2013
Transcriptional regulation of IL-15 expression during hematopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Colpitts SL,Stonier SW,Stoklasek TA,Root SH,Aguila HL,Schluns KS,Lefrançois L
Sun Sep 15 00:00:00 UTC 2013
MiR-223 deficiency increases eosinophil progenitor proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Lu TX,Lim EJ,Besse JA,Itskovich S,Plassard AJ,Fulkerson PC,Aronow BJ,Rothenberg ME
Fri Feb 15 00:00:00 UTC 2013
Altered immunity and dendritic cell activity in the periphery of mice after long-term engraftment with bone marrow from ultraviolet-irradiated mice.
Journal of immunology (Baltimore, Md. : 1950)
Ng RL,Scott NM,Strickland DH,Gorman S,Grimbaldeston MA,Norval M,Waithman J,Hart PH
Sat Jun 01 00:00:00 UTC 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
Tue Jan 15 00:00:00 UTC 2013
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.
Journal of immunology (Baltimore, Md. : 1950)
Bouffi C,Rochman M,Zust CB,Stucke EM,Kartashov A,Fulkerson PC,Barski A,Rothenberg ME
Tue Oct 15 00:00:00 UTC 2013
Inflammation-mediated notch signaling skews fanconi anemia hematopoietic stem cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Du W,Amarachintha S,Sipple J,Schick J,Steinbrecher K,Pang Q
Sun Sep 01 00:00:00 UTC 2013
Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Nanda SK,Smith H,Toth R,Arthur JSC,Cohen P
Sun Sep 01 00:00:00 UTC 2013
CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Srivatsan S,Swiecki M,Otero K,Cella M,Shaw AS
Sun Dec 15 00:00:00 UTC 2013
Batf3 and Id2 have a synergistic effect on Irf8-directed classical CD8α+ dendritic cell development.
Journal of immunology (Baltimore, Md. : 1950)
Jaiswal H,Kaushik M,Sougrat R,Gupta M,Dey A,Verma R,Ozato K,Tailor P
Sun Dec 15 00:00:00 UTC 2013
Adiponectin deficiency suppresses lymphoma growth in mice by modulating NK cells, CD8 T cells, and myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Han S,Jeong AL,Lee S,Park JS,Kim KD,Choi I,Yoon SR,Lee MS,Lim JS,Han SH,Yoon DY,Yang Y
Wed May 01 00:00:00 UTC 2013
Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.
The Journal of biological chemistry
Åhsberg J,Ungerbäck J,Strid T,Welinder E,Stjernberg J,Larsson M,Qian H,Sigvardsson M
Fri Nov 15 00:00:00 UTC 2013
Dynamic transformations of genome-wide epigenetic marking and transcriptional control establish T cell identity.
Cell
Zhang JA,Mortazavi A,Williams BA,Wold BJ,Rothenberg EV
Fri Apr 13 00:00:00 UTC 2012
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor.
Cell
Deng W,Lee J,Wang H,Miller J,Reik A,Gregory PD,Dean A,Blobel GA
Fri Jun 08 00:00:00 UTC 2012
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.
Blood
Tanaka S,Miyagi S,Sashida G,Chiba T,Yuan J,Mochizuki-Kashio M,Suzuki Y,Sugano S,Nakaseko C,Yokote K,Koseki H,Iwama A
Thu Aug 02 00:00:00 UTC 2012
Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3.
Blood
Lin DC,Yin T,Koren-Michowitz M,Ding LW,Gueller S,Gery S,Tabayashi T,Bergholz U,Kazi JU,Rönnstrand L,Stocking C,Koeffler HP
Thu Oct 18 00:00:00 UTC 2012
Emergence of NK-cell progenitors and functionally competent NK-cell lineage subsets in the early mouse embryo.
Blood
Tang Y,Peitzsch C,Charoudeh HN,Cheng M,Chaves P,Jacobsen SE,Sitnicka E
Thu Jul 05 00:00:00 UTC 2012
HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo.
Blood
Weigert A,Weichand B,Sekar D,Sha W,Hahn C,Mora J,Ley S,Essler S,Dehne N,Brüne B
Thu Oct 11 00:00:00 UTC 2012
IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors.
Blood
Becker AM,Michael DG,Satpathy AT,Sciammas R,Singh H,Bhattacharya D
Thu Mar 01 00:00:00 UTC 2012
KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice.
Blood
Zhao L,Melenhorst JJ,Alemu L,Kirby M,Anderson S,Kench M,Hoogstraten-Miller S,Brinster L,Kamikubo Y,Gilliland DG,Liu PP
Thu Feb 09 00:00:00 UTC 2012
Activated Gs signaling in osteoblastic cells alters the hematopoietic stem cell niche in mice.
Blood
Schepers K,Hsiao EC,Garg T,Scott MJ,Passegué E
Thu Oct 25 00:00:00 UTC 2012
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.
Blood
van de Laar L,van den Bosch A,Boonstra A,Binda RS,Buitenhuis M,Janssen HL,Coffer PJ,Woltman AM
Thu Dec 13 00:00:00 UTC 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
Mon Jun 04 00:00:00 UTC 2012
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
Mon Nov 19 00:00:00 UTC 2012
Bcl11a is essential for lymphoid development and negatively regulates p53.
The Journal of experimental medicine
Yu Y,Wang J,Khaled W,Burke S,Li P,Chen X,Yang W,Jenkins NA,Copeland NG,Zhang S,Liu P
Mon Dec 17 00:00:00 UTC 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
Mon Jan 16 00:00:00 UTC 2012
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.
The Journal of experimental medicine
Karnowski A,Chevrier S,Belz GT,Mount A,Emslie D,D'Costa K,Tarlinton DM,Kallies A,Corcoran LM
Mon Oct 22 00:00:00 UTC 2012
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Zandi S,Ahsberg J,Tsapogas P,Stjernberg J,Qian H,Sigvardsson M
Tue Sep 25 00:00:00 UTC 2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.
Proceedings of the National Academy of Sciences of the United States of America
Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J
Tue Oct 09 00:00:00 UTC 2012
Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis.
Proceedings of the National Academy of Sciences of the United States of America
Oyoshi MK,He R,Kanaoka Y,ElKhal A,Kawamoto S,Lewis CN,Austen KF,Geha RS
Tue Mar 27 00:00:00 UTC 2012
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America
Cunningham L,Finckbeiner S,Hyde RK,Southall N,Marugan J,Yedavalli VR,Dehdashti SJ,Reinhold WC,Alemu L,Zhao L,Yeh JR,Sood R,Pommier Y,Austin CP,Jeang KT,Zheng W,Liu P
Tue Sep 04 00:00:00 UTC 2012
Direct Toll-like receptor-mediated stimulation of hematopoietic stem and progenitor cells occurs in vivo and promotes differentiation toward macrophages.
Stem cells (Dayton, Ohio)
Megías J,Yáñez A,Moriano S,O'Connor JE,Gozalbo D,Gil ML
Sun Jul 01 00:00:00 UTC 2012
Purinergic P2X7 receptor drives T cell lineage choice and shapes peripheral γδ cells.
Journal of immunology (Baltimore, Md. : 1950)
Frascoli M,Marcandalli J,Schenk U,Grassi F
Sun Jul 01 00:00:00 UTC 2012
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Morita H,Nambu A,Arae K,Shimura E,Shibui A,Yamaguchi S,Suzukawa K,Nakanishi W,Oboki K,Kajiwara N,Ohno T,Ishii A,Körner H,Cua DJ,Suto H,Yoshimoto T,Iwakura Y,Yamasoba T,Ohta K,Sudo K,Saito H,Okumura K,Broide DH,Matsumoto K,Nakae S
Mon Oct 01 00:00:00 UTC 2012
NLRP3 inflammasome activity is negatively controlled by miR-223.
Journal of immunology (Baltimore, Md. : 1950)
Bauernfeind F,Rieger A,Schildberg FA,Knolle PA,Schmid-Burgk JL,Hornung V
Mon Oct 15 00:00:00 UTC 2012
Regulation of B cell linker protein transcription by PU.1 and Spi-B in murine B cell acute lymphoblastic leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Xu LS,Sokalski KM,Hotke K,Christie DA,Zarnett O,Piskorz J,Thillainadesan G,Torchia J,DeKoter RP
Mon Oct 01 00:00:00 UTC 2012
miR-451 regulates dendritic cell cytokine responses to influenza infection.
Journal of immunology (Baltimore, Md. : 1950)
Rosenberger CM,Podyminogin RL,Navarro G,Zhao GW,Askovich PS,Weiss MJ,Aderem A
Sat Dec 15 00:00:00 UTC 2012
The SWI/SNF-like BAF complex is essential for early B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Choi J,Ko M,Jeon S,Jeon Y,Park K,Lee C,Lee H,Seong RH
Sun Apr 15 00:00:00 UTC 2012
Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bahaie NS,Hosseinkhani MR,Ge XN,Kang BN,Ha SG,Blumenthal MS,Jessberger R,Rao SP,Sriramarao P
Wed Feb 01 00:00:00 UTC 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
Thu Mar 01 00:00:00 UTC 2012
Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Haque R,Lei F,Xiong X,Bian Y,Zhao B,Wu Y,Song J
Wed Aug 01 00:00:00 UTC 2012
Interferon-γ-producing immature myeloid cells confer protection against severe invasive group A Streptococcus infections.
Nature communications
Matsumura T,Ato M,Ikebe T,Ohnishi M,Watanabe H,Kobayashi K
Tue Feb 14 00:00:00 UTC 2012
Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.
The Journal of biological chemistry
Pauls E,Shpiro N,Peggie M,Young ER,Sorcek RJ,Tan L,Choi HG,Cohen P
Fri Jun 01 00:00:00 UTC 2012
IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.
PloS one
Heller NM,Gwinn WM,Donnelly RP,Constant SL,Keegan AD
Fri Jan 04 00:00:00 UTC 2013
Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.
PloS one
Vinay DS,Lee SJ,Kim CH,Oh HS,Kwon BS
Mon May 13 00:00:00 UTC 2013
Induction of histiocytic sarcoma in mouse skeletal muscle.
PloS one
Liu J,Hettmer S,Milsom MD,Hofmann I,Hua F,Miller C,Bronson RT,Wagers AJ
Thu Feb 07 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PloS one
Yamaguchi T,Hamanaka S,Kamiya A,Okabe M,Kawarai M,Wakiyama Y,Umino A,Hayama T,Sato H,Lee YS,Kato-Itoh M,Masaki H,Kobayashi T,Yamazaki S,Nakauchi H
Wed Jan 16 00:00:00 UTC 2013
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Immunity
Saitoh T,Satoh T,Yamamoto N,Uematsu S,Takeuchi O,Kawai T,Akira S
Fri Mar 25 00:00:00 UTC 2011
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Immunity
Fukui R,Saitoh S,Kanno A,Onji M,Shibata T,Ito A,Onji M,Matsumoto M,Akira S,Yoshida N,Miyake K
Fri Jul 22 00:00:00 UTC 2011
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.
Cancer cell
Mazzieri R,Pucci F,Moi D,Zonari E,Ranghetti A,Berti A,Politi LS,Gentner B,Brown JL,Naldini L,De Palma M
Tue Apr 12 00:00:00 UTC 2011
Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.
Cancer cell
Mali RS,Ramdas B,Ma P,Shi J,Munugalavadla V,Sims E,Wei L,Vemula S,Nabinger SC,Goodwin CB,Chan RJ,Traina F,Visconte V,Tiu RV,Lewis TA,Stern AM,Wen Q,Crispino JD,Boswell HS,Kapur R
Tue Sep 13 00:00:00 UTC 2011
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.
Blood
Singbrant S,Russell MR,Jovic T,Liddicoat B,Izon DJ,Purton LE,Sims NA,Martin TJ,Sankaran VG,Walkley CR
Thu May 26 00:00:00 UTC 2011
Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.
Blood
Heinonen KM,Vanegas JR,Brochu S,Shan J,Vainio SJ,Perreault C
Thu Nov 10 00:00:00 UTC 2011
Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential.
Blood
Chi AW,Chavez A,Xu L,Weber BN,Shestova O,Schaffer A,Wertheim G,Pear WS,Izon D,Bhandoola A
Thu Sep 08 00:00:00 UTC 2011
Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice.
Blood
Chen TH,Kambal A,Krysiak K,Walshauser MA,Raju G,Tibbitts JF,Walter MJ
Thu Feb 03 00:00:00 UTC 2011
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.
Blood
Tsapogas P,Zandi S,Åhsberg J,Zetterblad J,Welinder E,Jönsson JI,Månsson R,Qian H,Sigvardsson M
Thu Aug 04 00:00:00 UTC 2011
E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.
Blood
Yang Q,Esplin B,Borghesi L
Thu Mar 31 00:00:00 UTC 2011
IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
Blood
Saba I,Kosan C,Vassen L,Möröy T
Thu Mar 24 00:00:00 UTC 2011
Development of thymic NK cells from double negative 1 thymocyte precursors.
Blood
Vargas CL,Poursine-Laurent J,Yang L,Yokoyama WM
Thu Sep 29 00:00:00 UTC 2011
SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.
Blood
Zhang L,Friedman AD
Thu Aug 25 00:00:00 UTC 2011
In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.
Blood
Richie Ehrlich LI,Serwold T,Weissman IL
Thu Mar 03 00:00:00 UTC 2011
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Blood
Chan G,Cheung LS,Yang W,Milyavsky M,Sanders AD,Gu S,Hong WX,Liu AX,Wang X,Barbara M,Sharma T,Gavin J,Kutok JL,Iscove NN,Shannon KM,Dick JE,Neel BG,Braun BS
Thu Apr 21 00:00:00 UTC 2011
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice.
The Journal of clinical investigation
Weber C,Meiler S,Döring Y,Koch M,Drechsler M,Megens RT,Rowinska Z,Bidzhekov K,Fecher C,Ribechini E,van Zandvoort MA,Binder CJ,Jelinek I,Hristov M,Boon L,Jung S,Korn T,Lutz MB,Förster I,Zenke M,Hieronymus T,Junt T,Zernecke A
Fri Jul 01 00:00:00 UTC 2011
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia.
The Journal of experimental medicine
Heltemes-Harris LM,Willette MJ,Ramsey LB,Qiu YH,Neeley ES,Zhang N,Thomas DA,Koeuth T,Baechler EC,Kornblau SM,Farrar MA
Mon Jun 06 00:00:00 UTC 2011
Tolerogenic function of Blimp-1 in dendritic cells.
The Journal of experimental medicine
Kim SJ,Zou YR,Goldstein J,Reizis B,Diamond B
Mon Oct 24 00:00:00 UTC 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
Mon Jun 06 00:00:00 UTC 2011
Id2 expression delineates differential checkpoints in the genetic program of CD8α+ and CD103+ dendritic cell lineages.
The EMBO journal
Jackson JT,Hu Y,Liu R,Masson F,D'Amico A,Carotta S,Xin A,Camilleri MJ,Mount AM,Kallies A,Wu L,Smyth GK,Nutt SL,Belz GT
Tue May 17 00:00:00 UTC 2011
Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus.
Proceedings of the National Academy of Sciences of the United States of America
Calderón L,Boehm T
Tue May 03 00:00:00 UTC 2011
CCAAT/enhancer binding protein alpha (C/EBP(alpha))-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation.
Proceedings of the National Academy of Sciences of the United States of America
Di Tullio A,Vu Manh TP,Schubert A,Castellano G,Månsson R,Graf T
Tue Oct 11 00:00:00 UTC 2011
Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
Lau-Kilby AW,Kretz CC,Pechhold S,Price JD,Dorta S,Ramos H,Trinchieri G,Tarbell KV
Tue Feb 08 00:00:00 UTC 2011
Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells.
Haematologica
Nakagawa M,Tsuzuki S,Honma K,Taguchi O,Seto M
250-31L was used in Cell Culture to identify the additional cooperative gene(s) associated with BCL2 and MYC or MYC and CCND1.
Thu Sep 01 00:00:00 UTC 2011
Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Luna-Gomes T,Magalhães KG,Mesquita-Santos FP,Bakker-Abreu I,Samico RF,Molinaro R,Calheiros AS,Diaz BL,Bozza PT,Weller PF,Bandeira-Melo C
Thu Dec 15 00:00:00 UTC 2011
SIRPα/CD172a regulates eosinophil homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Verjan Garcia N,Umemoto E,Saito Y,Yamasaki M,Hata E,Matozaki T,Murakami M,Jung YJ,Woo SY,Seoh JY,Jang MH,Aozasa K,Miyasaka M
Thu Sep 01 00:00:00 UTC 2011
The dual functions of IL-1 receptor-associated kinase 2 in TLR9-mediated IFN and proinflammatory cytokine production.
Journal of immunology (Baltimore, Md. : 1950)
Wan Y,Kim TW,Yu M,Zhou H,Yamashita M,Kang Z,Yin W,Wang JA,Thomas J,Sen GC,Stark GR,Li X
Tue Mar 01 00:00:00 UTC 2011
A role for autophagic protein beclin 1 early in lymphocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Arsov I,Adebayo A,Kucerova-Levisohn M,Haye J,MacNeil M,Papavasiliou FN,Yue Z,Ortiz BD
Tue Feb 15 00:00:00 UTC 2011
TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection.
Journal of immunology (Baltimore, Md. : 1950)
Jelinek I,Leonard JN,Price GE,Brown KN,Meyer-Manlapat A,Goldsmith PK,Wang Y,Venzon D,Epstein SL,Segal DM
Tue Feb 15 00:00:00 UTC 2011
Thymic stromal lymphopoietin is produced by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kashyap M,Rochman Y,Spolski R,Samsel L,Leonard WJ
Mon Aug 01 00:00:00 UTC 2011
Candida albicans induces selective development of macrophages and monocyte derived dendritic cells by a TLR2 dependent signalling.
PloS one
Yáñez A,Megías J,O'Connor JE,Gozalbo D,Gil ML
Tue Feb 28 00:00:00 UTC 2012
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
Thu Mar 15 00:00:00 UTC 2012
Comprehensive methylome map of lineage commitment from haematopoietic progenitors.
Nature
Ji H,Ehrlich LI,Seita J,Murakami P,Doi A,Lindau P,Lee H,Aryee MJ,Irizarry RA,Kim K,Rossi DJ,Inlay MA,Serwold T,Karsunky H,Ho L,Daley GQ,Weissman IL,Feinberg AP
Thu Sep 16 00:00:00 UTC 2010
A reprogrammable mouse strain from gene-targeted embryonic stem cells.
Nature methods
Stadtfeld M,Maherali N,Borkent M,Hochedlinger K
Fri Jan 01 00:00:00 UTC 2010
Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
Immunity
Vonarbourg C,Mortha A,Bui VL,Hernandez PP,Kiss EA,Hoyler T,Flach M,Bengsch B,Thimme R,Hölscher C,Hönig M,Pannicke U,Schwarz K,Ware CF,Finke D,Diefenbach A
Wed Nov 24 00:00:00 UTC 2010
Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.
Blood
Chessa TA,Anderson KE,Hu Y,Xu Q,Rausch O,Stephens LR,Hawkins PT
Thu Dec 23 00:00:00 UTC 2010
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Valpha14-Jalpha18 TCRalpha gene.
Blood
Watarai H,Rybouchkin A,Hongo N,Nagata Y,Sakata S,Sekine E,Dashtsoodol N,Tashiro T,Fujii S,Shimizu K,Mori K,Masuda K,Kawamoto H,Koseki H,Taniguchi M
Thu Jan 14 00:00:00 UTC 2010
Identification of an NK/T cell-restricted progenitor in adult bone marrow contributing to bone marrow- and thymic-dependent NK cells.
Blood
Nozad Charoudeh H,Tang Y,Cheng M,Cilio CM,Jacobsen SE,Sitnicka E
Thu Jul 15 00:00:00 UTC 2010
Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity.
Blood
Mansson R,Zandi S,Welinder E,Tsapogas P,Sakaguchi N,Bryder D,Sigvardsson M
Thu Apr 01 00:00:00 UTC 2010
Essential role for focal adhesion kinase in regulating stress hematopoiesis.
Blood
Vemula S,Ramdas B,Hanneman P,Martin J,Beggs HE,Kapur R
Thu Nov 18 00:00:00 UTC 2010
Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors.
Blood
Wölfler A,Danen-van Oorschot AA,Haanstra JR,Valkhof M,Bodner C,Vroegindeweij E,van Strien P,Novak A,Cupedo T,Touw IP
Thu Nov 18 00:00:00 UTC 2010
The transcription factor Srf regulates hematopoietic stem cell adhesion.
Blood
Ragu C,Elain G,Mylonas E,Ottolenghi C,Cagnard N,Daegelen D,Passegué E,Vainchenker W,Bernard OA,Penard-Lacronique V
Thu Nov 25 00:00:00 UTC 2010
Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation.
Blood
Starck J,Weiss-Gayet M,Gonnet C,Guyot B,Vicat JM,Morlé F
Thu Dec 02 00:00:00 UTC 2010
HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice.
The Journal of clinical investigation
Khwaja SS,Liu H,Tong C,Jin F,Pear WS,van Deursen J,Bram RJ
Thu Jul 01 00:00:00 UTC 2010
Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.
The Journal of clinical investigation
Watarai H,Fujii S,Yamada D,Rybouchkin A,Sakata S,Nagata Y,Iida-Kobayashi M,Sekine-Kondo E,Shimizu K,Shozaki Y,Sharif J,Matsuda M,Mochiduki S,Hasegawa T,Kitahara G,Endo TA,Toyoda T,Ohara O,Harigaya K,Koseki H,Taniguchi M
Thu Jul 01 00:00:00 UTC 2010
Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.
The Journal of experimental medicine
Janas ML,Varano G,Gudmundsson K,Noda M,Nagasawa T,Turner M
Mon Jan 18 00:00:00 UTC 2010
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Chou S,Lodish HF
Tue Apr 27 00:00:00 UTC 2010
Bone marrow-derived hematopoietic cells undergo myogenic differentiation following a Pax-7 independent pathway.
Stem cells (Dayton, Ohio)
Xynos A,Corbella P,Belmonte N,Zini R,Manfredini R,Ferrari G
Sat May 01 00:00:00 UTC 2010
Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells.
Stem cells (Dayton, Ohio)
Zhou Z,French DL,Ma G,Eisenstein S,Chen Y,Divino CM,Keller G,Chen SH,Pan PY
Wed Mar 31 00:00:00 UTC 2010
Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function.
Journal of immunology (Baltimore, Md. : 1950)
Melillo JA,Song L,Bhagat G,Blazquez AB,Plumlee CR,Lee C,Berin C,Reizis B,Schindler C
Mon Mar 01 00:00:00 UTC 2010
CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes.
Journal of immunology (Baltimore, Md. : 1950)
Lai JC,Wlodarska M,Liu DJ,Abraham N,Johnson P
Sun Aug 15 00:00:00 UTC 2010
Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor.
Journal of immunology (Baltimore, Md. : 1950)
Dyer KD,Percopo CM,Xie Z,Yang Z,Kim JD,Davoine F,Lacy P,Druey KM,Moqbel R,Rosenberg HF
Tue Jun 01 00:00:00 UTC 2010
TGF-beta1 accelerates dendritic cell differentiation from common dendritic cell progenitors and directs subset specification toward conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Felker P,Seré K,Lin Q,Becker C,Hristov M,Hieronymus T,Zenke M
Mon Nov 01 00:00:00 UTC 2010
Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.
Journal of immunology (Baltimore, Md. : 1950)
Mohtashami M,Shah DK,Nakase H,Kianizad K,Petrie HT,Zúñiga-Pflücker JC
Thu Jul 15 00:00:00 UTC 2010
IL-33 induces IL-13-dependent cutaneous fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Rankin AL,Mumm JB,Murphy E,Turner S,Yu N,McClanahan TK,Bourne PA,Pierce RH,Kastelein R,Pflanz S
Mon Feb 01 00:00:00 UTC 2010
Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.
BMC genomics
Zetterblad J,Qian H,Zandi S,Månsson R,Lagergren A,Hansson F,Bryder D,Paulsson N,Sigvardsson M
Fri Feb 12 00:00:00 UTC 2010
Attenuation of vaccinia virus by the expression of human Flt3 ligand.
Virology journal
Zurkova K,Hainz P,Krystofova J,Kutinova L,Sanda M,Nemeckova S
Wed May 26 00:00:00 UTC 2010
Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.
The Journal of biological chemistry
Åhsberg J,Tsapogas P,Qian H,Zetterblad J,Zandi S,Månsson R,Jönsson JI,Sigvardsson M
Fri Nov 19 00:00:00 UTC 2010
Direct cell reprogramming is a stochastic process amenable to acceleration.
Nature
Hanna J,Saha K,Pando B,van Zon J,Lengner CJ,Creyghton MP,van Oudenaarden A,Jaenisch R
Thu Dec 03 00:00:00 UTC 2009
MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells.
Cell
Sarrazin S,Mossadegh-Keller N,Fukao T,Aziz A,Mourcin F,Vanhille L,Kelly Modis L,Kastner P,Chan S,Duprez E,Otto C,Sieweke MH
Thu Jul 23 00:00:00 UTC 2009
Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c.
Nature immunology
Stehling-Sun S,Dade J,Nutt SL,DeKoter RP,Camargo FD
Sun Mar 01 00:00:00 UTC 2009
Imaging of plasmacytoid dendritic cell interactions with T cells.
Blood
Mittelbrunn M,Martínez del Hoyo G,López-Bravo M,Martín-Cofreces NB,Scholer A,Hugues S,Fetler L,Amigorena S,Ardavín C,Sánchez-Madrid F
Thu Jan 01 00:00:00 UTC 2009
BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3.
Blood
Nordigården A,Kraft M,Eliasson P,Labi V,Lam EW,Villunger A,Jönsson JI
Thu Mar 05 00:00:00 UTC 2009
High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.
Blood
Tipping AJ,Pina C,Castor A,Hong D,Rodrigues NP,Lazzari L,May GE,Jacobsen SE,Enver T
Thu Mar 19 00:00:00 UTC 2009
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.
Blood
Russell LJ,Capasso M,Vater I,Akasaka T,Bernard OA,Calasanz MJ,Chandrasekaran T,Chapiro E,Gesk S,Griffiths M,Guttery DS,Haferlach C,Harder L,Heidenreich O,Irving J,Kearney L,Nguyen-Khac F,Machado L,Minto L,Majid A,Moorman AV,Morrison H,Rand V,Strefford JC,Schwab C,Tönnies H,Dyer MJ,Siebert R,Harrison CJ
Thu Sep 24 00:00:00 UTC 2009
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.
Blood
Gekas C,Rhodes KE,Gereige LM,Helgadottir H,Ferrari R,Kurdistani SK,Montecino-Rodriguez E,Bassel-Duby R,Olson E,Krivtsov AV,Armstrong S,Orkin SH,Pellegrini M,Mikkola HK
Thu Apr 09 00:00:00 UTC 2009
Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.
Blood
Serwold T,Ehrlich LI,Weissman IL
Thu Jan 22 00:00:00 UTC 2009
Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6.
Blood
Dyer KD,Percopo CM,Fischer ER,Gabryszewski SJ,Rosenberg HF
Thu Sep 24 00:00:00 UTC 2009
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy.
The Journal of clinical investigation
Montini E,Cesana D,Schmidt M,Sanvito F,Bartholomae CC,Ranzani M,Benedicenti F,Sergi LS,Ambrosi A,Ponzoni M,Doglioni C,Di Serio C,von Kalle C,Naldini L
Wed Apr 01 00:00:00 UTC 2009
Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.
The Journal of clinical investigation
Judge AD,Robbins M,Tavakoli I,Levi J,Hu L,Fronda A,Ambegia E,McClintock K,MacLachlan I
Sun Mar 01 00:00:00 UTC 2009
ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.
Proceedings of the National Academy of Sciences of the United States of America
XuFeng R,Boyer MJ,Shen H,Li Y,Yu H,Gao Y,Yang Q,Wang Q,Cheng T
Tue Oct 20 00:00:00 UTC 2009
STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.
Journal of biomedical science
Chen LS,Wei PC,Liu T,Kao CH,Pai LM,Lee CK
Thu Feb 19 00:00:00 UTC 2009
A method for prolonged imaging of motile lymphocytes.
Immunology and cell biology
Day D,Pham K,Ludford-Menting MJ,Oliaro J,Izon D,Russell SM,Gu M
Sun Feb 01 00:00:00 UTC 2009
The adhesion molecule esam1 is a novel hematopoietic stem cell marker.
Stem cells (Dayton, Ohio)
Ooi AG,Karsunky H,Majeti R,Butz S,Vestweber D,Ishida T,Quertermous T,Weissman IL,Forsberg EC
Sun Mar 01 00:00:00 UTC 2009
Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ohmura-Hoshino M,Matsuki Y,Mito-Yoshida M,Goto E,Aoki-Kawasumi M,Nakayama M,Ohara O,Ishido S
Tue Dec 01 00:00:00 UTC 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
Sun Nov 01 00:00:00 UTC 2009
NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.
Journal of immunology (Baltimore, Md. : 1950)
Wang D,Paz-Priel I,Friedman AD
Fri May 01 00:00:00 UTC 2009
Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.
Journal of immunology (Baltimore, Md. : 1950)
Ueda-Hayakawa I,Mahlios J,Zhuang Y
Fri May 01 00:00:00 UTC 2009
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Goodridge HS,Shimada T,Wolf AJ,Hsu YM,Becker CA,Lin X,Underhill DM
Thu Jan 15 00:00:00 UTC 2009
Pure Hemozoin is inflammatory in vivo and activates the NALP3 inflammasome via release of uric acid.
Journal of immunology (Baltimore, Md. : 1950)
Griffith JW,Sun T,McIntosh MT,Bucala R
Thu Oct 15 00:00:00 UTC 2009
An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Kool M,van Nimwegen M,Willart MA,Muskens F,Boon L,Smit JJ,Coyle A,Clausen BE,Hoogsteden HC,Lambrecht BN,Hammad H
Wed Jul 15 00:00:00 UTC 2009
A signaling polypeptide derived from an innate immune adaptor molecule can be harnessed as a new class of vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950)
Kobiyama K,Takeshita F,Ishii KJ,Koyama S,Aoshi T,Akira S,Sakaue-Sawano A,Miyawaki A,Yamanaka Y,Hirano H,Suzuki K,Okuda K
Sun Feb 01 00:00:00 UTC 2009
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions.
Journal of immunology (Baltimore, Md. : 1950)
Jeong M,Piao ZH,Kim MS,Lee SH,Yun S,Sun HN,Yoon SR,Chung JW,Kim TD,Jeon JH,Lee J,Kim HN,Choi JY,Choi I
Sat Aug 15 00:00:00 UTC 2009
Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Kumagai Y,Kumar H,Koyama S,Kawai T,Takeuchi O,Akira S
Wed Apr 01 00:00:00 UTC 2009
Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis.
PloS one
Aguilar S,Scotton CJ,McNulty K,Nye E,Stamp G,Laurent G,Bonnet D,Janes SM
Tue Nov 24 00:00:00 UTC 2009
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Cancer cell
Krivtsov AV,Feng Z,Lemieux ME,Faber J,Vempati S,Sinha AU,Xia X,Jesneck J,Bracken AP,Silverman LB,Kutok JL,Kung AL,Armstrong SA
Tue Nov 04 00:00:00 UTC 2008
IRF8 regulates B-cell lineage specification, commitment, and differentiation.
Blood
Wang H,Lee CH,Qi C,Tailor P,Feng J,Abbasi S,Atsumi T,Morse HC
Sat Nov 15 00:00:00 UTC 2008
Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development.
Blood
Kometani K,Moriyama M,Nakashima Y,Katayama Y,Wang SF,Yamasaki S,Saito T,Hattori M,Minato N
Mon Dec 01 00:00:00 UTC 2008
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice.
Blood
Zhou Y,Du W,Koretsky T,Bagby GC,Pang Q
Mon Sep 15 00:00:00 UTC 2008
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
Sat Nov 01 00:00:00 UTC 2008
Flow-cytometric phosphoprotein analysis reveals agonist and temporal differences in responses of murine hematopoietic stem/progenitor cells.
PloS one
Kalaitzidis D,Neel BG
Tue Feb 10 00:00:00 UTC 2009
TNF-alpha induces leukemic clonal evolution ex vivo in Fanconi anemia group C murine stem cells.
The Journal of clinical investigation
Li J,Sejas DP,Zhang X,Qiu Y,Nattamai KJ,Rani R,Rathbun KR,Geiger H,Williams DA,Bagby GC,Pang Q
Thu Nov 01 00:00:00 UTC 2007
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
Oncogene
Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y
Thu Dec 08 00:00:00 UTC 2005
