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Invitrogen
Human CPAMD8 (aa 879-966) Control Fragment Recombinant Protein
Product Details
RP-95000
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQR
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Unconjugated
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (25%), Rat (25%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-56707. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The CPAMD8 gene, known as C3 and pregnancy zone protein-like alpha-2-macroglobulin domain-containing 8, is involved in the development of ocular tissues. It has been linked to anterior segment dysgenesis (ASD) and congenital glaucoma, indicating its critical role in eye development. CPAMD8 functions primarily within the non-pigmented epithelium and might participate in cellular communication and structural integrity during the differentiation of retinal organoids. Loss-of-function mutations in CPAMD8 disrupt normal eye formation, leading to various ocular disorders. Recent advancements, such as the establishment of CPAMD8-GFP reporter human embryonic stem cell lines, enable real-time monitoring of its expression, thereby facilitating exploration of its biological functions in retinal differentiation processes. Bioinformatic evaluations and CRISPR/Cas9 technology have provided insights into CPAMD8's role in eye development, with gene editing approaches helping delineate its involvement in ocular health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2 macroglobulin family protein VIP; C3 and PZP-like, alpha-2-macroglobulin domain containing 8
Gene Aliases: K-CAP; VIP
Entrez Gene ID: (Human) 27151
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