HLA & Transplant Back to Basics Series

Discover the foundational principles of Human Leukocyte Antigens (HLA) in a dynamic and engaging learning environment tailored to both newcomers and professionals in the field seeking to refresh their knowledge. Participants will delve into the intricacies of HLA testing and methodologies, gaining valuable insights into the factors that influence transplant compatibility and outcomes. Join us to explore the science behind HLA. Thermo Fisher Scientific aims to be your partner in education, as we share a passion for learning and innovation in the HLA and transplant field.

HLA fundamentals

sceintists in the lab

HLA testing methodologies

sceintists in the lab

HLA fundamentals

This comprehensive webinar series, led by Linda Olsen from our technical training team, will provide an in-depth understanding some of the crucial aspects of transplant immunology and genetics.  It aims to support both newcomers and experienced professionals in refreshing their understanding of HLA foundational principles.

Episode 1: Molecular Biology and Genetics

This episode briefly summarizes fundamental knowledge supporting the study of HLA. This will include genetic inheritance, gene expression, and population dynamics, and how genetic information flows from DNA to proteins.
 

Episode 2: Immunology

This session will focus on the processes and components of the innate and adaptive arms of the immune system, including cells, receptors, and pathways important to the understanding of HLA.
 

Episode 3: HLA Proteins and Genes

This episode focuses directly on HLA proteins and genes. It will cover the HLA system in general: the various classes and loci of HLA, their expression and roles within the human body, and specifics of HLA genetics and nomenclature.

 

Episode 4: Anti-HLA Antibodies and Immune Responses

This episode describes antibodies and possible immune responses against HLA proteins. It will cover information about antibodies in general, specific aspects of anti-HLA antibodies, and the possible immune responses in solid organ and stem cell transplant.

Episode 5: Starting with Serology: History and Evolution of HLA Assays

This episode will summarize the development of HLA assays over time, from leukoagglutination, mixed lymphocyte reactions, and complement-dependent cytotoxicity to the more sensitive and specific assays in use today for genetic and immunologic testing related to HLA.
 

Episode 6: Clinical Applications of HLA Testing

This episode describes some of the ways HLA testing is used in clinical and research laboratories. Learners will take away a general overview of HLA testing in transplantation and other applications.

HLA testing methodologies

This webinar series initiative focuses on the scientific principles and technical details of laboratory assays crucial for HLA and transplantation. It aims to support both newcomers and experienced professionals in refreshing their understanding of relevant testing technologies. Each session covers different aspects of HLA testing methodologies and are tailored to provide a deep dive into the techniques, processes, and instrumentation used in HLA labs, making it a comprehensive educational resource.

Episode 1: DNA Assays for HLA: SSP and RT-PCR

DNA Assays for HLA - SSP and RT-PCR covers the principles and practices of SSP and RT-PCR techniques in HLA typing. It details workflows including PCR, gel electrophoresis, and LinkSeq for as DNA methods for HLA laboratories. The presentation underscores the continued importance of these classic DNA methods in HLA laboratories for their efficiency and rapid results.

Join live at one of our upcoming episodes!

Topic: DNA Assays for HLA: SSO
Instructor: Linda Olsen
Date: March 25th, 2025 | 8 am - 9 am (PST)
 

Topic: Antibody Assays for HLA
Instructor: James Jones & Shari Turner
Date: May 27th, 2025 | 8 am - 9 am (PST)
 

Topic: Flow Cytometry for HLA
Instructor: Linda Olsen
Date: July 29th, 2025 | 8 am - 9 am (PST)
 

Topic: The Evolution of Sequencing in HLA Typing
Instructor: Maureen Montgomery
Date: September 9th, 2025 | 8 am - 9 am (PST)
 

Topic: Principles of NGS
Instructor: Maureen Montgomery
Date: November 18th, 2025 | 8 am - 9 am (PST)

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These videos may contain general information relating to various medical conditions or their treatment. The information in this video is provided for informational purposes only and is not meant to be a substitute for advice provided by a doctor or other qualified health care professional. You should always consult with a doctor or other health care professional for medical advice or information about diagnosis and treatment.

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