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CORIN is a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. CORIN converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase.
ATC2; Atrial natriuretic peptide-converting enzyme; Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; AV273130; Corin; corin, serine peptidase; CRN; EC 3.4.21; Heart-specific serine proteinase ATC2; low density lipoprotein receptor-related protein 4; low density lipoprotein-related protein 4; Lrp4; MGC119742; PEE5; pro-ANP-convertase; pro-ANP-converting enzyme; PRSC; serine peptidase; serine protease; TMPRSS10; Transmembrane protease serine 10
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