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Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
bA51G5.2; BB633055; BMIQ18; C6orf117; MC2R accessory protein 2; melanocortin 2 receptor accessory protein 2; melanocortin-2 receptor accessory protein 2; Mrap2; RGD1309873
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