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This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
9630007J19Rik; AI413174; AI661011; D; d-120J; Dbv; Dilute; dilute lethal-20J protein; dilute myosin heavy chain, non-muscle; dilute-opisthotonus; Dop; flail; flailer; flr; GS1; MVa; MYH12; MYO5; Myo5a; myosin 5a; Myosin heavy chain 12; Myosin heavy chain p190; myosin I heavy chain isoform; myosin V; myosin VA; myosin VA (heavy chain 12, myosin); myosin VA (heavy chain 12, myoxin); myosin VA (heavy polypeptide 12, myoxin); myosin, heavy polypeptide kinase; myosin-12; Myosin-V; myosin-Va; MyoVA; myoxin; MYR12; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; p190 myosin heavy chain; Sev-1; unconventional myosin-Va
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