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Invitrogen

CTH Polyclonal Antibody

View all (23) CTH antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (1)

Application

FIGURE: 1 / 1

CTH Antibody (PA5-86839) in WB

Western blot analysis of CTH in Lane 1: HEK293T whole cell lysate, Lane 2: Raw264.7 whole cell lysate, Lane 3: PC12 whole cell lysate. Sample was incubated with CTH polyclonal antibody (Product # PA5-86839) using a 1:500 dilution.

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Product Details

PA5-86839

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to residues in Human CTH

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2803598

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CGL; CTL target antigen; cystathionase (cystathionine gamma-lyase); Cystathionine gamma-lyase; Cysteine desulfhydrase; Cysteine-protein sulfhydrase; Gamma-cystathionase; Homocysteine desulfhydrase; homoserine deaminase; homoserine dehydratase; MGC9471; PRB-RA; Probasin-related antigen

Gene Aliases: 0610010I13Rik; AI314617; BC019483; CSE; CTH; Cys3; H

UniProt ID: (Human) P32929, (Rat) P18757, (Mouse) Q8VCN5

Entrez Gene ID: (Human) 1491, (Rat) 24962, (Mouse) 107869

Function(s)

cystathionine gamma-synthase activity cystathionine gamma-lyase activity protein binding calmodulin binding carbon-sulfur lyase activity pyridoxal phosphate binding L-cystine L-cysteine-lyase (deaminating) homocysteine desulfhydrase activity L-cysteine desulfhydrase activity cystathionine beta-lyase activity catalytic activity lyase activity lyase

Process(es)

sulfur amino acid catabolic process cysteine metabolic process protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine cysteine biosynthetic process via cystathionine cysteine biosynthetic process transsulfuration endoplasmic reticulum unfolded protein response positive regulation of I-kappaB kinase/NF-kappaB signaling protein sulfhydration positive regulation of NF-kappaB transcription factor activity protein homotetramerization hydrogen sulfide biosynthetic process 'de novo' L-methionine biosynthetic process positive regulation of aortic smooth muscle cell differentiation negative regulation of apoptotic signaling pathway glutathione metabolic process negative regulation of cell proliferation negative regulation of cell growth negative regulation of apoptotic process homocysteine metabolic process cellular amino acid biosynthetic process

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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