Search Thermo Fisher Scientific
- Contact Us
- Quick Order
-
Don't have an account ? Create Account
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
PA5-121911
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phe21-Gly104 (Accession Q96QR1), with N-terminal His and GST Tag
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2915483
Target Information
HIN-1, also known as High In Normal-1 or Secretoglobin Family 3A Member 1 (SCGB3A1), is a gene located on chromosome 5q33.3. It encodes a protein that is predominantly expressed in normal mammary epithelial cells and is thought to function in epithelial cell signaling, contributing to cellular differentiation and maintaining normal tissue architecture. The HIN-1 gene is often silenced or downregulated in various cancers, particularly breast cancer, due to hypermethylation of its promoter region, suggesting a potential tumor suppressor role. Loss of HIN-1 expression has been implicated in the progression of malignancies by disrupting normal cell signaling pathways, thereby facilitating oncogenesis. Given its significant downregulation in cancerous tissues, HIN-1 is being explored as a biomarker for early cancer detection and may provide insights into novel therapeutic strategies that aim to restore its expression and normal cellular functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: cytokine high in normal-1; Cytokine HIN-1; High in normal 1; Pneumo secretory protein 2; PnSP-2; Secretoglobin family 3A member 1; secretoglobin, family 3A, member 1; UGRP2MGC87867; Uteroglobin-related protein 2
Gene Aliases: HIN-1; HIN1; LU105; PnSP-2; PNSP2; SCGB3A1; UGRP2; UNQ629/PRO1245
UniProt ID: (Human) Q96QR1
Entrez Gene ID: (Human) 92304, (Pig) 100515999
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support