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Immunogen sequence: YALAGVSFE IKAEDDQPLP GVLLSLSGGL FRSNLLTQDN GILTFSNLSP GQYYFKPMMK EFRFEPSSQM IEVQEGQNLK ITITGYRTAY SCYGTVSSLN GEPEQGVAME AVGQNDCSIY GEDTVTDEEG KFRLRGLLPG CVYHVQLKAE GNDHIERALP HHRVIEVGNN DIDDVNIIVF RQINQFDLSG NVITSSEYLP TLWVKLYKSE NLDNPIQTVS LGQSLFFHFP PLLRDGENYV VLLDSTLPRS QYDYILPQVS FTAVGYHKHI TLIFNPTRKL PEQDIAQGSY IALPLTLLVL LAGYNHDKLI PLLLQLTSRL QGVGALGQAA SDNSGPEDAK RQAKKQKTRR T (873-1222 aa encoded by BC041131)
This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BOS complex subunit NOMO2; Nodal modulator 2; pM5 protein 2; pM5 protein, centromeric copy
Gene Aliases: Nomo; NOMO2; PM5
UniProt ID: (Human) Q5JPE7
Entrez Gene ID: (Human) 283820
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