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Immunogen sequence: TAEARKRKAK SCICHVCGVH LNRLHSCLYC VFFGCFTKKH IHEHAKAKRH NLAIDLMYGG IYCFLCQDYI YDKDMEIIAK EEQRKAWKMQ GVGEKFSTWE P
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
Gene Aliases: AI427806; KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02
Entrez Gene ID: (Human) 23326, (Mouse) 216825
Molecular Function:
cysteine protease
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