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Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
AI427806; Deubiquitinating enzyme 22; KIAA1063; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific peptidase 22; ubiquitin specific protease 22; ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; ubiquitin-specific-processing protease 22; Usp22; USP3L
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