Krios 5 Cryo-TEM

Atomic resolution cryo-EM with high data fidelity and throughput

 

Designed for high performance single particle analysis, cryo-electron tomography (cryo-ET) and microcrystal electron diffraction (MicroED), the Thermo Scientific Krios 5 Cryo-Transmission Electron Microscope (Cryo-TEM) is capable of quickly producing high-quality structures thanks to a unique focus on data fidelity. Increased automation of routine alignments, improved optical precision, and AI-assistance with Thermo Scientific Smart EPU Software make the Krios 5 Cryo-TEM a highly productive and “ready-to-use” system for all expertise levels across multiple scientific fields. The inclusion of Thermo Scientific Tomography 5 Software enhances productivity through built-in motion correction and access to information beyond the Nyquist frequency. Designed with sustainability in mind, the Krios 5 Cryo-TEM features a more compact design and Eco modes that reduce energy consumption while the instrument is not in use.

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Explore the structure of life with the Krios 5 Cryo-TEM

The Krios 5 Cryo-TEM is a 300 kV cryo-transmission electron microscope that enables 3D visualization of proteins and molecular machines at atomic level, revealing their localization and dynamics within the architecture of the cell.

Krios 5 Cryo-TEM benefits

  • Up to 25% faster throughput with high data fidelity, AI-powered Smart EPU Plugins, extended aberration-free image shift (AFIS) and magnification calibration accuracy within 1% for single particle analysis
  • Accelerated cryo-electron tomography workflow with multigrid data collection, Discovery Viewer integrated within Thermo Scientific CryoFlow Software
  • On-the-fly motion correction and EER 8K decoding, automatically capturing data beyond the Nyquist limit with Tomography 5 Software for crisp tomograms and high image quality required for sub-tomogram averaging
  • Vacuum Capsule provides robust and contamination-free transfer from the Thermo Scientific Arctis Cryo-Plasma-FIB
  • Built-in sustainability provides energy-saving Eco modes with fast wake up scheduling, plus environmental impact certification with the My Green Lab® ACT® Ecolabel

Get a closer look at the new Krios 5 Cryo-TEM in our virtual event

Get a closer look at the new Krios 5 Cryo-TEM in our virtual event

Krios 5 Cryo-TEM highlights

Atomic resolution cryo-EM

Solve more structures at record-breaking resolutions with the Krios 5 Cryo-TEM. When not in use, low-power Eco modes decrease power consumption and the instrument’s carbon footprint.

Cryo EM atomic structure of apoferritin resolved with Krios Cryo TEM

Cryo-TEM AI assistance and accessories

Receive instant feedback to guide data collection in real-time with AI-enabled solutions. Achieve robust, contamination-free transfer with the Thermo Scientific Vacuum Capsule.

Krios Cryo-TEM accessories include the pictured Thermo Scientific Vacuum Capsule

Krios 5 Cryo-TEM applications

The Krios 5 Cryo-TEM allows you to uncover the behavior, function, and structure of cells, providing critical insights for a range of biological applications from cell and structural biology to drug discovery and more.

Reconstructed amyloid protein structure created with Krios Cryo TEM

Krios Cryo-TEM resources

Learn more from scientists who are using the Krios Cryo-TEM in their research and take a closer look with on-demand webinars.

Testimonial video for the Krios Cryo-TEM

Cryo-TEM service and support

To ensure optimal system performance, we provide you access to a world-class network of field service experts, technical support, and workflow validation.

Working on a Krios Cryo-TEM

Cryo-EM in biosafety labs

Our decontamination solution enables pathogen research and comprehensive instrument service in higher biosafety-level containment facilities (e.g. BSL3).

Decontamination solution for Krios Cryo-TEM

For Research Use Only. Not for use in diagnostic procedures.