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Application
FIGURE: 1 / 4
REPIN1 Antibody (MA5-57992) in IHC (P)
Immunohistochemistry analysis of REPIN1 with paraffin-embedded Human colon carcinoma tissue. The tissue was incubated with REPIN1 Recombinant Monoclonal Antibody (Product # MA5-57992) using a 1:200 dilution (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6.0) prior to staining.
Product Details
MA5-57992
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2X2E9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 376-567 of human REPIN1 (NP_037532.2).
Conjugate
Unconjugated
Form
Liquid
Concentration
1.01 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Dry ice (international)
RRID
AB_3681014
Product Specific Information
Immunogen sequence: SCDDCGRSFR LERFLRAHQR QHTGERPFTC AECGKNFGKK THLVAHSRVH SGERPFACEE CGRRFSQGSH LAAHRRDHAP DRPFVCPDCG KAFRHKPYLA AHRRIHTGEK PYVCPDCGKA FSQKSNLVSH RRIHTGERPY ACPDCDRSFS QKSNLITHRK SHIRDGAFCC AICGQTFDDE ERLLAHQKKH DV
Target Information
Replication initiator 1 (REPIN1) is a gene encoding a zinc-finger protein that plays a critical role in various metabolic processes. Located on chromosome 7 in humans, REPIN1 is prominently expressed in liver and adipose tissues. It is associated with the regulation of body weight and triglyceride levels, as evidenced by its locus within a quantitative trait locus (QTL) related to these metabolic traits. The REPIN1 protein is involved in enhancing DNA bending, which is crucial for replication initiation. Studies have shown that deleting REPIN1 in the liver can lead to improved insulin sensitivity and altered lipid metabolism, with secondary effects on adipose tissue. Additionally, REPIN1 is implicated in iron metabolism and apoptosis regulation, further underscoring its multifaceted role in cellular processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; ATT-binding protein; DHFR oribeta-binding protein RIP60; DNA-binding protein REPIN1; H_DJ0584D14.12; replication initiation region protein (60kD); Zinc finger protein 464; zinc finger protein 464 (RIP60); zinc finger protein AP4
Gene Aliases: AP4; REPIN1; RIP60; Zfp464; ZNF464
UniProt ID: (Human) Q9BWE0
Entrez Gene ID: (Human) 29803
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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