Rubottom oxidation reaction

In 1974, G.M. Rubottom, A.G. Brook, and A. Hassner independently created a method to prepare alpha-hydroxy aldehydes and ketones through the oxidation of their silyl enol ethers using meta-chloro peroxy benzoic acid (mCPBA). Today, the peroxyacid oxidation of silyl enol ether substrates to prepare the corresponding alpha-hydroxy carbonyl compounds is known as the Rubottom oxidation. Synthesis of the potent anti-thrombotic (+/-)rishirilide B utilized the Rubottom oxidation, as did the synthesis of the antitumor antibiotic FR901464.

Review available Thermo Scientific products for the Rubottom oxidation reaction:

Catalog # Name Size Price (USD) Qty
L00286.14 3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water Each
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L00286.22 3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water Each
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L00286.36 3-Chloroperoxybenzoic acid, 50-55%, cont. ca 10% 3-chlorobenzoic acid, balance water Each
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A12535.09 Trimethylsilyl trifluoromethanesulfonate, 99% Each
39.65

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Ends: 30-Jun-2025

46.30
Save 6.65 (14%)
A12535.18 Trimethylsilyl trifluoromethanesulfonate, 99% Each
126.65

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Ends: 26-Sep-2025

149.00
Save 22.35 (15%)
A12535.30 Trimethylsilyl trifluoromethanesulfonate, 99% Each
473.65

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Ends: 26-Sep-2025

557.00
Save 83.35 (15%)
A12646.AK Triethylamine, 99% Each
38.60
A12646.AP Triethylamine, 99% Each
47.90
A12646.0F Triethylamine, 99% Each
116.65

Special offer

Online exclusive

Ends: 26-Sep-2025

137.00
Save 20.35 (15%)

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