Chromatography and Mass Spectrometry Reagents

Thermo Scientific™ Formic Acid is high-purity solvent supplied in glass ampules as a convenient, contamination-free alternative for preparing elution solvents for HPLC separations of protein and peptides.

Thermo Scientific™ Pierce Dimethylsulfoxide (DMSO) is a sequencing-grade preparation with high purity and consistent absorptivity properties, for use in HPLC and mass spectrometry methods.

Use specially manufactured and packaged Thermo Scientific™ Silylation Grade Solvents to meet the exacting needs of silylation and other sensitive derivatization reactions. They are purified, dried, and packaged under nitrogen in convenient Thermo Scientific™ Hypo-Vial™ Sample Storage Vials, and are...

Thermo Scientific™ Pierce Trifluoroacetic Acid (TFA) is manufactured and tested to meet strict specifications that ensure superior performance for use as an ion-pairing agent in reverse-phase peptide separations.

Use Thermo Scientific™ BSTFA + 1–10% TMCS Silylation Reagent for analytes that are difficult to silylate. Stronger than BSTFA alone, this catalyzed formulation is ideal for derivatizing compounds such as fatty acid amides and slightly hindered hydroxyls for GC analysis.

Thermo Scientific™ Pierce Dimethylsulfoxide (DMSO) is a sequencing-grade preparation with high purity and consistent absorptivity properties for use in HPLC and mass spectrometry methods.

For accurate, sensitive, on-column methylation and detection by GC analysis use Thermo Scientific™ MethElute™ Reagent (TMPAH). It is ideally suited for the quantitative methylation and detection of barbiturates, sedatives, xanthine bases, phenolic alkaloids, and phenytoin, giving a single...

Produce stable TBDMS derivatives for GC analysis with the Thermo Scientific™ MTBSTFA and MTBSTFA + 1% TBDMCS Silylation Reagent. MTBSTFA derivatizes hydroxyl, carboxyl, thiol and primary and secondary amines with typically >96% yields, and the reaction byproducts are volatile and neutral.

Thermo Scientific Pierce Dimethylformamide (DMF) is a sequencing-grade preparation with high purity and consistent absorptivity properties for use in HPLC and mass spectrometry methods.

Trifluoroacylate primary and secondary amines, hydroxyl and thiol groups, and carbohydrates with the Thermo Scientific™ MBTFA Acylation Reagent. The principal byproduct N-methyltrifluoroacetamine is stable, volatile, and does not present problems in subsequent GC.

Use Thermo Scientific™ MSTFA and MSTFA + 1% TMCS Silylation Reagent for GC analyses of early eluting compounds that would otherwise be obscured in the chromatogram. MSTFA, the most volatile TMS-amide available, and its byproduct N-methyltrifluoroacetamide typically elute with the solvent front,...

Employ a reagent-catalyst solvent mixture, for one-step derivatization with the Thermo Scientific™ Tri-Sil HTP (HDMS:TMCS:Pyridine) Reagent, Composed of HMDS, TMCS and high-purity pyridine, it rapidly produces TMS derivatives of polar compounds for GC analysis and biochemical synthesis.

Derivatize hydroxyls compounds, particularly carbohydrates with Thermo Scientific™ Tri-Sil TP (TMSI:Pyridine) Reagent. Comprising TMSI in pyridine, this reagent silylates alcohols and phenols, organic acids, hydroxylamines, amino acids, carbohydrates, flavonoids, glycols and polyglycols,...

For siliconizing glass surfaces use Thermo Scientific™ Hydrocarbon Soluble Siliconizing Fluid. This short chain, clear polymeric silicone fluid consists primarily of dichlorooctamethyltetrasiloxane and is soluble in organic solvents.

Thermo Scientific Pierce Pyridine (PY) is a sequencing-grade preparation with high purity and consistent absorptivity properties for use in HPLC and mass spectrometry methods.